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Association details:
| Biomarker: | IDH1 R132H |
|---|---|
| Cancer: | Anaplastic Astrocytoma |
| Drug: | temozolomide (DNA synthesis inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813
Excerpt:
Of the 196 patients, 111 were tested for IDH1-R132H status (60 RT+TMZ and 51 RT+NU)....RT+TMZ did not appear to significantly improve OS or TTP for AA compared with RT+ NU. RT+TMZ was better tolerated. IDH1-R132H mutation was associated with longer survival.
DOI:
10.1016/S1470-2045(20)30464-2
Trial ID:
