^
Association details:
Evidence:
Evidence Level:
Sensitive: B - Late Trials
New
Title:

Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813

Excerpt:
Of the 196 patients, 111 were tested for IDH1-R132H status (60 RT+TMZ and 51 RT+NU)....RT+TMZ did not appear to significantly improve OS or TTP for AA compared with RT+ NU. RT+TMZ was better tolerated. IDH1-R132H mutation was associated with longer survival.
DOI:
10.1016/S1470-2045(20)30464-2
Trial ID: