^
Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

Targeting IDH1/2 mutant cancers with unique combinations of DNA repair inhibitors

Excerpt:
Here, we demonstrate that novel combinations of DNA repair inhibitors can be utilized to synergistically target IDH1/2-mutant glioma cells. We have shown that in an in vivo flank model bearing IDH1 R132H mutation, AZD6738 (ATRi) and Olaparib (PARPi) combination treatment reduces the tumor burden significantly relative to monotherapy and vehicle.
DOI:
10.1158/1538-7445.AM2020-1059