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BIOMARKER:
HR positive
i
Other names:
ESR1, Era, ESR, NR3A1, ER, ER beta, PGR, Progesterone receptor, Nuclear receptor subfamily 3 group C member 3, NR3C3
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Entrez ID:
2099
;
5241
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
PIK3CA mutation + HR positive (16)
PIK3CA mutation + ER positive (10)
ESR1 mutation + HR positive (6)
ESR1 wild-type + HR positive (4)
BRCA1 mutation + HR positive (3)
BRCA2 mutation + HR positive (3)
ER positive + PIK3CA H1047R (3)
FGFR1 amplification + HR positive (3)
HR positive + BRCA2 mutation (3)
HR-positive + PIK3CA wild-type (3)
PIK3CA exon 20 mutation + HR positive (3)
AKT1 E17K + HR positive (2)
AKT1 mutation + ER positive (2)
AKT1 mutation + HR positive (2)
ER Y537S + ER positive (2)
ER positive + TP53 mutation (2)
ER-L (2)
HR negative + BRCA1 mutation (2)
HR negative + BRCA2 mutation (2)
HR positive + BRCA1 mutation (2)
HR positive + MYC amplification (2)
HR positive + TP53 mutation (2)
PIK3CA mutation + ER negative (2)
PTEN deletion + ER positive (2)
AKT1 mutation + ER negative (1)
BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)
BRCA2 mutation + ER positive (1)
BRCA2 mutation + ER positive + PGR positive (1)
CCND1 mutation + HR positive (1)
CCND2 mutation + HR positive (1)
CCNE1 overexpression + PIK3CA muattion + ER positive (1)
CCNE2 overexpression + PIK3CA mutation + ER positive (1)
CDK4 mutation + HR positive (1)
CDKN1B mutation + HR positive (1)
EGFR mutation + ER positive (1)
ER D538G + ER positive (1)
ER E380Q + ER positive (1)
ER L536H + ER D538G + CCND1 amplification (1)
ER Y537N + ER positive (1)
ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)
ER positive + ESR1 mutation + CCND1 amplification (1)
ER positive + ESR1 mutation + FGFR1 amplification (1)
ER positive + ESR1 mutation + PIK3CA mutation (1)
ER positive + ESR1 mutation + TP53 mutation (1)
ER positive + FGFR1 amplification (1)
ER positive + FGFR3 amplification (1)
ER positive + HER-2 D769H + HER-2 V777L (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
ER positive + ZNF217 overexpression (1)
ER underexpression + ER Y537S (1)
ERBB4 H809G + ER positive (1)
ESR1 mutation + PIK3CA mutation + HR positive (1)
FGF19 amplification + ER positive (1)
FGF3 amplification + ER positive (1)
FGF4 amplification + ER positive (1)
FOXA1 expression + ER positive (1)
HER-2 amplification + ER positive + PGR negative (1)
HR negative + EGFR amplification (1)
HR positive + APOBEC signature (1)
HR positive + AURKA amplification (1)
HR positive + AURKA mutation (1)
HR positive + BRAF V600E (1)
HR positive + BRCA1 mutation + PALB2 mutation (1)
HR positive + BRCA2 mutation + PALB2 mutation (1)
HR positive + BRIP1 amplification (1)
HR positive + CCND1 amplification (1)
HR positive + HER-2 amplification (1)
HR positive + HER-2 mutation (1)
HR positive + MYC mutation (1)
HR positive + PIK3CA exon 10 mutation (1)
HR positive + PTEN deletion (1)
HR positive + RAD51C amplification (1)
HR positive + RB1 mutation (1)
HR positive + TMB-H (1)
HR positive + TMB-L (1)
High HDAC6 score + HR positive (1)
KRAS mutation + CDK9 overexpression + HR positive (1)
KRAS mutation + ER expression (1)
KRAS mutation + HR positive (1)
MTOR mutation + HR positive (1)
MYC mutation + ER positive (1)
PIK3CA E542K + HR positive (1)
PIK3CA amplification + PIK3CA mutation + HR positive (1)
PIK3CA exon 7 mutation + HR positive (1)
PIK3CA exon 9 mutation + HR positive (1)
PIK3CA mutation + ESR1 wild-type (1)
PIK3CA mutation + HR positive + HER-2 negative (1)
PIK3CA wild-type+ ESR1 wild-type (1)
PTEN mutation + HR positive (1)
TP53 wild-type + ER positive (1)
AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)
ER negative + HER-2 positive + PIK3CA H1047R (0)
ER positive + BRCA1 mutation (0)
ER positive + BRCA2 mutation (0)
ER positive + HER-2 negative + ER mutation (0)
HR positive + HER-2 negative + TMB-L (0)
PIK3CA mutation + ER negative + PGR positive (0)
PIK3CA mutation + HR positive (16)
PIK3CA mutation + ER positive (10)
ESR1 mutation + HR positive (6)
ESR1 wild-type + HR positive (4)
BRCA1 mutation + HR positive (3)
BRCA2 mutation + HR positive (3)
ER positive + PIK3CA H1047R (3)
FGFR1 amplification + HR positive (3)
HR positive + BRCA2 mutation (3)
HR-positive + PIK3CA wild-type (3)
PIK3CA exon 20 mutation + HR positive (3)
AKT1 E17K + HR positive (2)
AKT1 mutation + ER positive (2)
AKT1 mutation + HR positive (2)
ER Y537S + ER positive (2)
ER positive + TP53 mutation (2)
ER-L (2)
HR negative + BRCA1 mutation (2)
HR negative + BRCA2 mutation (2)
HR positive + BRCA1 mutation (2)
HR positive + MYC amplification (2)
HR positive + TP53 mutation (2)
PIK3CA mutation + ER negative (2)
PTEN deletion + ER positive (2)
AKT1 mutation + ER negative (1)
BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)
BRCA2 mutation + ER positive (1)
BRCA2 mutation + ER positive + PGR positive (1)
CCND1 mutation + HR positive (1)
CCND2 mutation + HR positive (1)
CCNE1 overexpression + PIK3CA muattion + ER positive (1)
CCNE2 overexpression + PIK3CA mutation + ER positive (1)
CDK4 mutation + HR positive (1)
CDKN1B mutation + HR positive (1)
EGFR mutation + ER positive (1)
ER D538G + ER positive (1)
ER E380Q + ER positive (1)
ER L536H + ER D538G + CCND1 amplification (1)
ER Y537N + ER positive (1)
ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)
ER positive + ESR1 mutation + CCND1 amplification (1)
ER positive + ESR1 mutation + FGFR1 amplification (1)
ER positive + ESR1 mutation + PIK3CA mutation (1)
ER positive + ESR1 mutation + TP53 mutation (1)
ER positive + FGFR1 amplification (1)
ER positive + FGFR3 amplification (1)
ER positive + HER-2 D769H + HER-2 V777L (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
ER positive + ZNF217 overexpression (1)
ER underexpression + ER Y537S (1)
ERBB4 H809G + ER positive (1)
ESR1 mutation + PIK3CA mutation + HR positive (1)
FGF19 amplification + ER positive (1)
FGF3 amplification + ER positive (1)
FGF4 amplification + ER positive (1)
FOXA1 expression + ER positive (1)
HER-2 amplification + ER positive + PGR negative (1)
HR negative + EGFR amplification (1)
HR positive + APOBEC signature (1)
HR positive + AURKA amplification (1)
HR positive + AURKA mutation (1)
HR positive + BRAF V600E (1)
HR positive + BRCA1 mutation + PALB2 mutation (1)
HR positive + BRCA2 mutation + PALB2 mutation (1)
HR positive + BRIP1 amplification (1)
HR positive + CCND1 amplification (1)
HR positive + HER-2 amplification (1)
HR positive + HER-2 mutation (1)
HR positive + MYC mutation (1)
HR positive + PIK3CA exon 10 mutation (1)
HR positive + PTEN deletion (1)
HR positive + RAD51C amplification (1)
HR positive + RB1 mutation (1)
HR positive + TMB-H (1)
HR positive + TMB-L (1)
High HDAC6 score + HR positive (1)
KRAS mutation + CDK9 overexpression + HR positive (1)
KRAS mutation + ER expression (1)
KRAS mutation + HR positive (1)
MTOR mutation + HR positive (1)
MYC mutation + ER positive (1)
PIK3CA E542K + HR positive (1)
PIK3CA amplification + PIK3CA mutation + HR positive (1)
PIK3CA exon 7 mutation + HR positive (1)
PIK3CA exon 9 mutation + HR positive (1)
PIK3CA mutation + ESR1 wild-type (1)
PIK3CA mutation + HR positive + HER-2 negative (1)
PIK3CA wild-type+ ESR1 wild-type (1)
PTEN mutation + HR positive (1)
TP53 wild-type + ER positive (1)
AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)
ER negative + HER-2 positive + PIK3CA H1047R (0)
ER positive + BRCA1 mutation (0)
ER positive + BRCA2 mutation (0)
ER positive + HER-2 negative + ER mutation (0)
HR positive + HER-2 negative + TMB-L (0)
PIK3CA mutation + ER negative + PGR positive (0)
›
Related tests:
FoundationOne® CDx (110)
FoundationOne® Liquid CDx (21)
Prosigna™ Breast Cancer Prognostic Gene Signature Assay (3)
FoundationOne® CDx (110)
FoundationOne® Liquid CDx (21)
Prosigna™ Breast Cancer Prognostic Gene Signature Assay (3)
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
HR positive
HER2 Positive Breast Cancer
HR positive
HER2 Positive Breast Cancer
neratinib
Sensitive: A1 - Approval
neratinib
Sensitive
:
A1
neratinib
Sensitive: A1 - Approval
neratinib
Sensitive
:
A1
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
sacituzumab govitecan-hziy
Sensitive: A1 - Approval
sacituzumab govitecan-hziy
Sensitive
:
A1
sacituzumab govitecan-hziy
Sensitive: A1 - Approval
sacituzumab govitecan-hziy
Sensitive
:
A1
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
palbociclib
Sensitive: A1 - Approval
palbociclib
Sensitive
:
A1
palbociclib
Sensitive: A1 - Approval
palbociclib
Sensitive
:
A1
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
ribociclib
Sensitive: A1 - Approval
ribociclib
Sensitive
:
A1
ribociclib
Sensitive: A1 - Approval
ribociclib
Sensitive
:
A1
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
abemaciclib
Sensitive: A1 - Approval
abemaciclib
Sensitive
:
A1
abemaciclib
Sensitive: A1 - Approval
abemaciclib
Sensitive
:
A1
HR positive
Hormone Receptor Positive Breast Cancer
HR positive
Hormone Receptor Positive Breast Cancer
ribociclib
Sensitive: A1 - Approval
ribociclib
Sensitive
:
A1
ribociclib
Sensitive: A1 - Approval
ribociclib
Sensitive
:
A1
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
everolimus
Sensitive: A1 - Approval
everolimus
Sensitive
:
A1
everolimus
Sensitive: A1 - Approval
everolimus
Sensitive
:
A1
HR positive
HER2 Positive Breast Cancer
HR positive
HER2 Positive Breast Cancer
trastuzumab-strf
Sensitive: A1 - Approval
trastuzumab-strf
Sensitive
:
A1
trastuzumab-strf
Sensitive: A1 - Approval
trastuzumab-strf
Sensitive
:
A1
HR positive
Hormone Receptor Positive Breast Cancer
HR positive
Hormone Receptor Positive Breast Cancer
olaparib
Sensitive: A1 - Approval
olaparib
Sensitive
:
A1
olaparib
Sensitive: A1 - Approval
olaparib
Sensitive
:
A1
HR positive
Hormone Receptor Positive Breast Cancer
HR positive
Hormone Receptor Positive Breast Cancer
letrozole
Sensitive: A1 - Approval
letrozole
Sensitive
:
A1
letrozole
Sensitive: A1 - Approval
letrozole
Sensitive
:
A1
HR positive
Hormone Receptor Positive Breast Cancer
HR positive
Hormone Receptor Positive Breast Cancer
anastrozole
Sensitive: A1 - Approval
anastrozole
Sensitive
:
A1
anastrozole
Sensitive: A1 - Approval
anastrozole
Sensitive
:
A1
HR positive
Hormone Receptor Positive Breast Cancer
HR positive
Hormone Receptor Positive Breast Cancer
talazoparib
Sensitive: A1 - Approval
talazoparib
Sensitive
:
A1
talazoparib
Sensitive: A1 - Approval
talazoparib
Sensitive
:
A1
HR positive
Hormone Receptor Positive Breast Cancer
HR positive
Hormone Receptor Positive Breast Cancer
fulvestrant
Sensitive: A1 - Approval
fulvestrant
Sensitive
:
A1
fulvestrant
Sensitive: A1 - Approval
fulvestrant
Sensitive
:
A1
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
fulvestrant
Sensitive: A1 - Approval
fulvestrant
Sensitive
:
A1
fulvestrant
Sensitive: A1 - Approval
fulvestrant
Sensitive
:
A1
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
capivasertib
Sensitive: A1 - Approval
capivasertib
Sensitive
:
A1
capivasertib
Sensitive: A1 - Approval
capivasertib
Sensitive
:
A1
HR positive
HER2 Positive Breast Cancer
HR positive
HER2 Positive Breast Cancer
trastuzumab
Sensitive: A2 - Guideline
trastuzumab
Sensitive
:
A2
trastuzumab
Sensitive: A2 - Guideline
trastuzumab
Sensitive
:
A2
HR positive
HER2 Positive Breast Cancer
HR positive
HER2 Positive Breast Cancer
lapatinib
Sensitive: A2 - Guideline
lapatinib
Sensitive
:
A2
lapatinib
Sensitive: A2 - Guideline
lapatinib
Sensitive
:
A2
HR positive
HER2 Positive Breast Cancer
HR positive
HER2 Positive Breast Cancer
trastuzumab + pertuzumab
Sensitive: A2 - Guideline
trastuzumab + pertuzumab
Sensitive
:
A2
trastuzumab + pertuzumab
Sensitive: A2 - Guideline
trastuzumab + pertuzumab
Sensitive
:
A2
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
toremifene
Sensitive: A2 - Guideline
toremifene
Sensitive
:
A2
toremifene
Sensitive: A2 - Guideline
toremifene
Sensitive
:
A2
HR positive
HER2 Positive Breast Cancer
HR positive
HER2 Positive Breast Cancer
HER2 inhibitor
Sensitive: A2 - Guideline
HER2 inhibitor
Sensitive
:
A2
HER2 inhibitor
Sensitive: A2 - Guideline
HER2 inhibitor
Sensitive
:
A2
HR positive
HER2 Positive Breast Cancer
HR positive
HER2 Positive Breast Cancer
HER2 inhibitor + Aromatase inhibitor
Sensitive: A2 - Guideline
HER2 inhibitor + Aromatase inhibitor
Sensitive
:
A2
HER2 inhibitor + Aromatase inhibitor
Sensitive: A2 - Guideline
HER2 inhibitor + Aromatase inhibitor
Sensitive
:
A2
HR positive
Male Breast Cancer
HR positive
Male Breast Cancer
Aromatase inhibitor
Sensitive: A2 - Guideline
Aromatase inhibitor
Sensitive
:
A2
Aromatase inhibitor
Sensitive: A2 - Guideline
Aromatase inhibitor
Sensitive
:
A2
HR positive
Male Breast Cancer
HR positive
Male Breast Cancer
tamoxifen
Sensitive: A2 - Guideline
tamoxifen
Sensitive
:
A2
tamoxifen
Sensitive: A2 - Guideline
tamoxifen
Sensitive
:
A2
HR positive
Hormone Receptor Positive Breast Cancer
HR positive
Hormone Receptor Positive Breast Cancer
palbociclib
Resistant: A2 - Guideline
palbociclib
Resistant
:
A2
palbociclib
Resistant: A2 - Guideline
palbociclib
Resistant
:
A2
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
Aromatase inhibitor
Sensitive: A2 - Guideline
Aromatase inhibitor
Sensitive
:
A2
Aromatase inhibitor
Sensitive: A2 - Guideline
Aromatase inhibitor
Sensitive
:
A2
HR positive
Hormone Receptor Positive Breast Cancer
HR positive
Hormone Receptor Positive Breast Cancer
everolimus
Sensitive: A2 - Guideline
everolimus
Sensitive
:
A2
everolimus
Sensitive: A2 - Guideline
everolimus
Sensitive
:
A2
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
fulvestrant
Sensitive: A2 - Guideline
fulvestrant
Sensitive
:
A2
fulvestrant
Sensitive: A2 - Guideline
fulvestrant
Sensitive
:
A2
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
letrozole
Sensitive: A2 - Guideline
letrozole
Sensitive
:
A2
letrozole
Sensitive: A2 - Guideline
letrozole
Sensitive
:
A2
HR positive
HER2 Positive Breast Cancer
HR positive
HER2 Positive Breast Cancer
trastuzumab + lapatinib
Sensitive: A2 - Guideline
trastuzumab + lapatinib
Sensitive
:
A2
trastuzumab + lapatinib
Sensitive: A2 - Guideline
trastuzumab + lapatinib
Sensitive
:
A2
HR positive
HER2 Positive Breast Cancer
HR positive
HER2 Positive Breast Cancer
Aromatase inhibitor
Sensitive: A2 - Guideline
Aromatase inhibitor
Sensitive
:
A2
Aromatase inhibitor
Sensitive: A2 - Guideline
Aromatase inhibitor
Sensitive
:
A2
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
estradiol
Sensitive: A2 - Guideline
estradiol
Sensitive
:
A2
estradiol
Sensitive: A2 - Guideline
estradiol
Sensitive
:
A2
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
megestrol
Sensitive: A2 - Guideline
megestrol
Sensitive
:
A2
megestrol
Sensitive: A2 - Guideline
megestrol
Sensitive
:
A2
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