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BIOMARKER:

HER-2 V777L

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Entrez ID:

Related biomarkers:

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HER-2 amplification + RAS wild-type + BRAF wild-type (9)

HER-2 positive + HER-2 amplification (4)

RAS wild-type + HER-2 positive (4)

HER-2 amplification + KRAS G12D (3)

BRAF wild-type + HER-2 positive (2)

BRCA1 mutation + HER-2 negative (2)

BRCA2 mutation + HER-2 negative (2)

HER-2 S310F + HER-2 amplification (2)

HER-2 amplification + EGFR-ZNF880 fusion + EGFR E114K (2)

HER-2 amplification + HER-2 L755S (2)

HER-2 amplification + PD-L1 expression (2)

HER-2 amplification + RAS wild-type (2)

HER-2 expression + HER-2 D769H (2)

HER-2 expression + HER-2 L869R (2)

HER-2 expression + HER-2 amplification (2)

HER-2 expression + TMB-H (2)

RAS wild-type + BRAF wild-type + HER-2 positive (2)

TMB-H + HER-2 positive (2)

AR positive + HER-2 amplification (1)

BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)

CD74-NRG1 fusion + EGFR mutation + HER-2 mutation (1)

EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)

EGFR T790M + HER-2 amplification (1)

EGFR exon 19 deletion + EGFR T790M + EGFR C797S + HER-2 amplification (1)

ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)

ER positive + HER-2 D769H + HER-2 V777L (1)

ERBB2 G778A + CCNE1 amplification (1)

ERBB3 mutation + HER-2 amplification (1)

ERBB4 mutation + HER-2 positive (1)

HER-2 amplification + AXL expression (1)

HER-2 amplification + BRAF wild-type (1)

HER-2 amplification + CCNE1 expression (1)

HER-2 amplification + EGFR mutation (1)

HER-2 amplification + ER positive + PGR negative (1)

HER-2 amplification + HER-2 R157W (1)

HER-2 amplification + HER-2 mutation (1)

HER-2 amplification + KRAS exon 2 wild-type (1)

HER-2 amplification + KRAS wild-type (1)

HER-2 elevation (1)

HER-2 elevation + TMB-H (1)

HER-2 elevation + TMB-L (1)

HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)

HER-2 mutation + HER-2 positive (1)

HER-2 mutation + TMB-H (1)

HER-2 overexpression + CCNE1 amplification (1)

HER-2 overexpression + HER-2 amplification (1)

HER-2 overexpression + KRAS G12C (1)

HER-2 overexpression + KRAS wild-type (1)

HER-2 overexpression + PTEN deletion (1)

HER-2 overexpression + RAS wild-type (1)

HER-2 positive + APC mutation (1)

HER-2 positive + GATA6 amplification (1)

HER-2 positive + MYC amplification (1)

HER-2 positive + TP53 mutation (1)

HER-2 underexpression + CCNE1 amplification (1)

HR positive + HER-2 amplification (1)

HR positive + HER-2 mutation (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

KRAS mutation + HER-2 positive (1)

MSI-H + HER-2 amplification (1)

MSI-H/dMMR + HER-2 mutation (1)

NF1 mutation + HER-2 positive (1)

PD-L1 overexpression + HER-2 exon 20 insertion (1)

PIK3C3 mutation + HER-2 positive (1)

PIK3CA H1047R + HER-2 amplification (1)

PIK3CA mutation + HER-2 amplification (1)

PIK3CA mutation + HER-2 positive (1)

PIK3CA mutation + HR positive + HER-2 negative (1)

PIK3R1 mutation + HER-2 positive (1)

POLE E790Q + ERBB2 amplification + TMB-H (1)

RAS wild-type + HER-2 amplification (1)

RAS wild-type + HER-2 overexpression (1)

STAT6 deletion + HER-2 overexpression (1)

ER negative + HER-2 positive + PIK3CA H1047R (0)

ER positive + HER-2 negative + ER mutation (0)

HER-2 amplification + KRAS G12C (0)

HER-2 exon 20 mutation + HER-2 amplification (0)

HER-2 positive + FGFR1 amplification (0)

HR positive + HER-2 negative + TMB-L (0)

PIK3CA E453K + HER-2 positive (0)

PIK3CA E542K + HER-2 positive (0)

PIK3CA E542Q + HER-2 positive (0)

PIK3CA H1047L + HER-2 positive (0)

PIK3CA H1047R + HER-2 positive (0)

PIK3CA N345K + HER-2 positive (0)

PIK3CA amplification + HER-2 positive (0)

HER-2 amplification + RAS wild-type + BRAF wild-type (9)

HER-2 positive + HER-2 amplification (4)

RAS wild-type + HER-2 positive (4)

HER-2 amplification + KRAS G12D (3)

BRAF wild-type + HER-2 positive (2)

BRCA1 mutation + HER-2 negative (2)

BRCA2 mutation + HER-2 negative (2)

HER-2 S310F + HER-2 amplification (2)

HER-2 amplification + EGFR-ZNF880 fusion + EGFR E114K (2)

HER-2 amplification + HER-2 L755S (2)

HER-2 amplification + PD-L1 expression (2)

HER-2 amplification + RAS wild-type (2)

HER-2 expression + HER-2 D769H (2)

HER-2 expression + HER-2 L869R (2)

HER-2 expression + HER-2 amplification (2)

HER-2 expression + TMB-H (2)

RAS wild-type + BRAF wild-type + HER-2 positive (2)

TMB-H + HER-2 positive (2)

AR positive + HER-2 amplification (1)

BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)

CD74-NRG1 fusion + EGFR mutation + HER-2 mutation (1)

EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)

EGFR T790M + HER-2 amplification (1)

EGFR exon 19 deletion + EGFR T790M + EGFR C797S + HER-2 amplification (1)

ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)

ER positive + HER-2 D769H + HER-2 V777L (1)

ERBB2 G778A + CCNE1 amplification (1)

ERBB3 mutation + HER-2 amplification (1)

ERBB4 mutation + HER-2 positive (1)

HER-2 amplification + AXL expression (1)

HER-2 amplification + BRAF wild-type (1)

HER-2 amplification + CCNE1 expression (1)

HER-2 amplification + EGFR mutation (1)

HER-2 amplification + ER positive + PGR negative (1)

HER-2 amplification + HER-2 R157W (1)

HER-2 amplification + HER-2 mutation (1)

HER-2 amplification + KRAS exon 2 wild-type (1)

HER-2 amplification + KRAS wild-type (1)

HER-2 elevation (1)

HER-2 elevation + TMB-H (1)

HER-2 elevation + TMB-L (1)

HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)

HER-2 mutation + HER-2 positive (1)

HER-2 mutation + TMB-H (1)

HER-2 overexpression + CCNE1 amplification (1)

HER-2 overexpression + HER-2 amplification (1)

HER-2 overexpression + KRAS G12C (1)

HER-2 overexpression + KRAS wild-type (1)

HER-2 overexpression + PTEN deletion (1)

HER-2 overexpression + RAS wild-type (1)

HER-2 positive + APC mutation (1)

HER-2 positive + GATA6 amplification (1)

HER-2 positive + MYC amplification (1)

HER-2 positive + TP53 mutation (1)

HER-2 underexpression + CCNE1 amplification (1)

HR positive + HER-2 amplification (1)

HR positive + HER-2 mutation (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

KRAS mutation + HER-2 positive (1)

MSI-H + HER-2 amplification (1)

MSI-H/dMMR + HER-2 mutation (1)

NF1 mutation + HER-2 positive (1)

PD-L1 overexpression + HER-2 exon 20 insertion (1)

PIK3C3 mutation + HER-2 positive (1)

PIK3CA H1047R + HER-2 amplification (1)

PIK3CA mutation + HER-2 amplification (1)

PIK3CA mutation + HER-2 positive (1)

PIK3CA mutation + HR positive + HER-2 negative (1)

PIK3R1 mutation + HER-2 positive (1)

POLE E790Q + ERBB2 amplification + TMB-H (1)

RAS wild-type + HER-2 amplification (1)

RAS wild-type + HER-2 overexpression (1)

STAT6 deletion + HER-2 overexpression (1)

ER negative + HER-2 positive + PIK3CA H1047R (0)

ER positive + HER-2 negative + ER mutation (0)

HER-2 amplification + KRAS G12C (0)

HER-2 exon 20 mutation + HER-2 amplification (0)

HER-2 positive + FGFR1 amplification (0)

HR positive + HER-2 negative + TMB-L (0)

PIK3CA E453K + HER-2 positive (0)

PIK3CA E542K + HER-2 positive (0)

PIK3CA E542Q + HER-2 positive (0)

PIK3CA H1047L + HER-2 positive (0)

PIK3CA H1047R + HER-2 positive (0)

PIK3CA N345K + HER-2 positive (0)

PIK3CA amplification + HER-2 positive (0)

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HER-2 V777L	HER2 Negative Breast Cancer	HER-2 V777L	HER2 Negative Breast Cancer	neratinib Sensitive: C2 – Inclusion Criteria neratinib Sensitive : C2	neratinib Sensitive: C2 – Inclusion Criteria neratinib Sensitive : C2
HER-2 V777L	Breast Cancer	HER-2 V777L	Breast Cancer	trastuzumab Resistant: C3 – Early Trials trastuzumab Resistant : C3	trastuzumab Resistant: C3 – Early Trials trastuzumab Resistant : C3
HER-2 V777L	HER2 Negative Breast Cancer	HER-2 V777L	HER2 Negative Breast Cancer	trastuzumab + neratinib Sensitive: C3 – Early Trials trastuzumab + neratinib Sensitive : C3	trastuzumab + neratinib Sensitive: C3 – Early Trials trastuzumab + neratinib Sensitive : C3
HER-2 V777L	Gastric Cancer	HER-2 V777L	Gastric Cancer	tucatinib Sensitive: D – Preclinical tucatinib Sensitive : D	tucatinib Sensitive: D – Preclinical tucatinib Sensitive : D
HER-2 V777L	Breast Cancer	HER-2 V777L	Breast Cancer	ado-trastuzumab emtansine Resistant: D – Preclinical ado-trastuzumab emtansine Resistant : D	ado-trastuzumab emtansine Resistant: D – Preclinical ado-trastuzumab emtansine Resistant : D
HER-2 V777L	Colorectal Cancer	HER-2 V777L	Colorectal Cancer	trastuzumab + tucatinib Sensitive: D – Preclinical trastuzumab + tucatinib Sensitive : D	trastuzumab + tucatinib Sensitive: D – Preclinical trastuzumab + tucatinib Sensitive : D
HER-2 V777L	Colorectal Cancer	HER-2 V777L	Colorectal Cancer	tucatinib Sensitive: D – Preclinical tucatinib Sensitive : D	tucatinib Sensitive: D – Preclinical tucatinib Sensitive : D
HER-2 V777L	Non Small Cell Lung Cancer	HER-2 V777L	Non Small Cell Lung Cancer	tucatinib Sensitive: D – Preclinical tucatinib Sensitive : D	tucatinib Sensitive: D – Preclinical tucatinib Sensitive : D
HER-2 V777L	Colorectal Cancer	HER-2 V777L	Colorectal Cancer	cetuximab Resistant: D – Preclinical cetuximab Resistant : D	cetuximab Resistant: D – Preclinical cetuximab Resistant : D
HER-2 V777L	Colorectal Cancer	HER-2 V777L	Colorectal Cancer	panitumumab Resistant: D – Preclinical panitumumab Resistant : D	panitumumab Resistant: D – Preclinical panitumumab Resistant : D