^
Association details:
Biomarker:HER-2 V777L
Cancer:Colorectal Cancer
Drug:Vectibix (panitumumab) (EGFR inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
New
Title:

HER2 Activating Mutations Are Targets for Colorectal Cancer Treatment

Excerpt:
Five HER2 mutations were tested in NCI-H508 cells, and all mutations produced resistance to cetuximab and panitumumab.
DOI:
10.1158/2159-8290.CD-14-1211