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Association details:
Biomarker:
HER-2 amplification + RAS wild-type + BRAF wild-type
Cancer:
Rectal Cancer
Drug:
Herceptin (trastuzumab)
(
HER2 inhibitor
) +
Tukysa (tucatinib)
(
HER2 inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: A2 - Guideline
Source:
NCCN
Published date:
01/25/2023
Excerpt:
Rectal cancer....Tucatinib in combination with trastuzumab added as a treatment option for HER2-amplified and RAS and BRAF WT.
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