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GENE:

GLI1 (GLI Family Zinc Finger 1)

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oncoReveal™ Core LBx

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GLI1 overexpression	Basal Cell Carcinoma	GLI1 overexpression	Basal Cell Carcinoma	vismodegib Resistant: C3 – Early Trials vismodegib Resistant : C3	vismodegib Resistant: C3 – Early Trials vismodegib Resistant : C3
GLI1 overexpression	Non Small Cell Lung Cancer	GLI1 overexpression	Non Small Cell Lung Cancer	erlotinib Resistant: C3 – Early Trials erlotinib Resistant : C3	erlotinib Resistant: C3 – Early Trials erlotinib Resistant : C3
GLI1 expression	Non Small Cell Lung Cancer	GLI1 expression	Non Small Cell Lung Cancer	erlotinib Sensitive: C3 – Early Trials erlotinib Sensitive : C3	erlotinib Sensitive: C3 – Early Trials erlotinib Sensitive : C3
GLI1 overexpression	Thyroid Gland Papillary Carcinoma	GLI1 overexpression	Thyroid Gland Papillary Carcinoma	larotrectinib Sensitive: C4 – Case Studies larotrectinib Sensitive : C4	larotrectinib Sensitive: C4 – Case Studies larotrectinib Sensitive : C4
PTCH1-GLI1 fusion	Ovarian Cancer	PTCH1-GLI1 fusion	Ovarian Cancer	pazopanib Sensitive: C4 – Case Studies pazopanib Sensitive : C4	pazopanib Sensitive: C4 – Case Studies pazopanib Sensitive : C4
PTCH1-GLI1 fusion	Ovarian Cancer	PTCH1-GLI1 fusion	Ovarian Cancer	pembrolizumab Resistant: C4 – Case Studies pembrolizumab Resistant : C4	pembrolizumab Resistant: C4 – Case Studies pembrolizumab Resistant : C4
GLI1 expression	Pancreatic Ductal Adenocarcinoma	GLI1 expression	Pancreatic Ductal Adenocarcinoma	sonidegib Sensitive: D – Preclinical sonidegib Sensitive : D	sonidegib Sensitive: D – Preclinical sonidegib Sensitive : D