Pts with CD20+ R/R FL (grade [G] 1–3A) who had received ≥2 prior lines of systemic tx received epcoritamab...The ORR was 82%, with a complete response (CR) rate of 63% (Figure). The median time to response and CR was 1.4 and 1.5 mo, respectively. ORRs/CR rates were generally consistent across prespecified high-risk subgroups: double refractory, 76%/56%; refractory to last prior tx, 74%/51%; POD24, 80%/61%...Single-agent epcoritamab SC resulted in deep and durable responses with high ORR and CR rates in hard-to-treat, high-risk pts with R/R FL. Responses were consistent across subgroups.