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BIOMARKER:
EML4-ALK fusion
i
Other names:
EML4, EMAP Like 4, Restrictedly Overexpressed Proliferation-Associated Protein, Echinoderm Microtubule-Associated Protein-Like 4, Echinoderm Microtubule Associated Protein Like 4, Ropp 120, C2orf2, EMAP-4, EMAPL4, ROPP120, ELP120, NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
;
27436
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ALK fusion (23)
EML4-ALK variant 3 (8)
STRN-ALK fusion (5)
ALK-HIP1 fusion (4)
EML4-ALK L1196M (4)
FN1-ALK fusion (4)
NPM1-ALK F1174C (4)
NPM1-ALK fusion (4)
EML4-ALK variant 1 (3)
NPM1-ALK I1171N (3)
NPM1-ALK I1171T (3)
NPM1-ALK L1196Q (3)
RANBP2-ALK fusion (3)
SLC8A1-ALK fusion (3)
ALK-EML4_V5 (2)
ALK-HLA-DRB1 fusion (2)
CAD-ALK fusion (2)
CARS1‐ALK fusion (2)
CLTC-ALK fusion (2)
CMTR1-ALK fusion (2)
DCTN1-ALK fusion (2)
EML4-ALK C1156Y (2)
EML4-ALK G1202R (2)
EML4-ALK G1269A (2)
EML4-ALK I1171S (2)
EML4-ALK variant 2 (2)
HIP1-ALK I1171N (2)
KIF5B-ALK fusion (2)
LMO7-ALK fusion (2)
EML4-NTRK3 fusion (2)
EML4-RET fusion (2)
ACVR1-ALK fusion (1)
ALK-DCHS1 fusion (1)
ALK-EML4_V1 (1)
ALK-EML4_V2 (1)
ALK-EML4_V3 (1)
ALK-EML4_V5a (1)
ALK-KIF5B fusion (1)
ALK-LIMS1 fusion (1)
ALK-PPFIBP1 fusion (1)
ALK-ROS1 fusion (1)
CCDC6-ALK fusion (1)
CCDC85A-ALK fusion (1)
CLIP4-ALK fusion (1)
COX7A2L-ALK fusion (1)
CTNND1-ALK fusion (1)
CUX1-ALK fusion (1)
Chr t(2;17)(p23;q23) CLTC/ALK (1)
Chr t(2;5)(p23;q35) NPM1/ALK (1)
EML4-ALK + ALK-PEX13 (1)
EML4-ALK E13;A20 (1)
EML4-ALK F1174C (1)
EML4-ALK I1171T (1)
EML4-ALK S1206Y (1)
EML4-ALK fusion + ALK-FEZ2 fusion (1)
EML4-ALK fusion + ALK-SSH2 fusion (1)
EML4-ALK fusion + ARID2-ALK fusion (1)
EML4-ALK fusion + CDK15-ALK fusion (1)
EML4-ALK variant 3a (1)
EML4-ALK variant 3b (1)
EML4_E13-ALK_E19 fusion (1)
EML4_E20-ALK_E19 fusion (1)
EML4_E6-ALK_E18(V3) (1)
EML6-ALK fusion + FBXO11-ALK fusion (1)
ERC1-ALK fusion (1)
GHR-ALK fusion (1)
HIVEP1-ALK fusion (1)
KANK4-ALK fusion (1)
KIDINS220-ALK fusion (1)
KIF13A-ALK fusion (1)
KLC1-ALK fusion (1)
KLHL31-LRRC1-ALK fusion (1)
LINC01173-ALK fusion + LOC388942-ALK fusion (1)
LOC101927285-ALK fusion (1)
LTBP1-ALK fusion (1)
LTBP1-ALK fusion + HIP1-ALK fusion (1)
LTBP1_E2-ALK_E11 fusion (1)
MPRIP-ALK fusion (1)
MRPS9-ALK fusion (1)
MYH9-ALK + ALK-WDR43 (1)
NBEA-ALK fusion + EML4-ALK fusion (1)
NKAIN2-ALK fusion (1)
NPM-ALK fusion (1)
PRKCB-ALK fusion (1)
PTH2R-ALK fusion (1)
RANBP2-ALK + TMEM217-ALK (1)
SDK1-ALK fusion (1)
SETD2-ALK fusion + EML4-ALK fusion (1)
SPECC1L‑ALK fusion (1)
STRN exon 2-ALK exon 20 fusion (1)
TFG-ALK fusion (1)
TNIP2-ALK fusion (1)
TOGARAM2-ALK fusion (1)
UGP2-ALK fusion (1)
CDK15-ALK fusion (0)
EML6-ALK fusion (0)
FBXO11-ALK fusion (0)
ALK fusion (23)
EML4-ALK variant 3 (8)
STRN-ALK fusion (5)
ALK-HIP1 fusion (4)
EML4-ALK L1196M (4)
FN1-ALK fusion (4)
NPM1-ALK F1174C (4)
NPM1-ALK fusion (4)
EML4-ALK variant 1 (3)
NPM1-ALK I1171N (3)
NPM1-ALK I1171T (3)
NPM1-ALK L1196Q (3)
RANBP2-ALK fusion (3)
SLC8A1-ALK fusion (3)
ALK-EML4_V5 (2)
ALK-HLA-DRB1 fusion (2)
CAD-ALK fusion (2)
CARS1‐ALK fusion (2)
CLTC-ALK fusion (2)
CMTR1-ALK fusion (2)
DCTN1-ALK fusion (2)
EML4-ALK C1156Y (2)
EML4-ALK G1202R (2)
EML4-ALK G1269A (2)
EML4-ALK I1171S (2)
EML4-ALK variant 2 (2)
HIP1-ALK I1171N (2)
KIF5B-ALK fusion (2)
LMO7-ALK fusion (2)
EML4-NTRK3 fusion (2)
EML4-RET fusion (2)
ACVR1-ALK fusion (1)
ALK-DCHS1 fusion (1)
ALK-EML4_V1 (1)
ALK-EML4_V2 (1)
ALK-EML4_V3 (1)
ALK-EML4_V5a (1)
ALK-KIF5B fusion (1)
ALK-LIMS1 fusion (1)
ALK-PPFIBP1 fusion (1)
ALK-ROS1 fusion (1)
CCDC6-ALK fusion (1)
CCDC85A-ALK fusion (1)
CLIP4-ALK fusion (1)
COX7A2L-ALK fusion (1)
CTNND1-ALK fusion (1)
CUX1-ALK fusion (1)
Chr t(2;17)(p23;q23) CLTC/ALK (1)
Chr t(2;5)(p23;q35) NPM1/ALK (1)
EML4-ALK + ALK-PEX13 (1)
EML4-ALK E13;A20 (1)
EML4-ALK F1174C (1)
EML4-ALK I1171T (1)
EML4-ALK S1206Y (1)
EML4-ALK fusion + ALK-FEZ2 fusion (1)
EML4-ALK fusion + ALK-SSH2 fusion (1)
EML4-ALK fusion + ARID2-ALK fusion (1)
EML4-ALK fusion + CDK15-ALK fusion (1)
EML4-ALK variant 3a (1)
EML4-ALK variant 3b (1)
EML4_E13-ALK_E19 fusion (1)
EML4_E20-ALK_E19 fusion (1)
EML4_E6-ALK_E18(V3) (1)
EML6-ALK fusion + FBXO11-ALK fusion (1)
ERC1-ALK fusion (1)
GHR-ALK fusion (1)
HIVEP1-ALK fusion (1)
KANK4-ALK fusion (1)
KIDINS220-ALK fusion (1)
KIF13A-ALK fusion (1)
KLC1-ALK fusion (1)
KLHL31-LRRC1-ALK fusion (1)
LINC01173-ALK fusion + LOC388942-ALK fusion (1)
LOC101927285-ALK fusion (1)
LTBP1-ALK fusion (1)
LTBP1-ALK fusion + HIP1-ALK fusion (1)
LTBP1_E2-ALK_E11 fusion (1)
MPRIP-ALK fusion (1)
MRPS9-ALK fusion (1)
MYH9-ALK + ALK-WDR43 (1)
NBEA-ALK fusion + EML4-ALK fusion (1)
NKAIN2-ALK fusion (1)
NPM-ALK fusion (1)
PRKCB-ALK fusion (1)
PTH2R-ALK fusion (1)
RANBP2-ALK + TMEM217-ALK (1)
SDK1-ALK fusion (1)
SETD2-ALK fusion + EML4-ALK fusion (1)
SPECC1L‑ALK fusion (1)
STRN exon 2-ALK exon 20 fusion (1)
TFG-ALK fusion (1)
TNIP2-ALK fusion (1)
TOGARAM2-ALK fusion (1)
UGP2-ALK fusion (1)
CDK15-ALK fusion (0)
EML6-ALK fusion (0)
FBXO11-ALK fusion (0)
›
Associations
News
Trials
VERI cancer hierarchy
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EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
crizotinib
Resistant: C2 – Inclusion Criteria
crizotinib
Resistant
:
C2
crizotinib
Resistant: C2 – Inclusion Criteria
crizotinib
Resistant
:
C2
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
alectinib
Sensitive: C3 – Early Trials
alectinib
Sensitive
:
C3
alectinib
Sensitive: C3 – Early Trials
alectinib
Sensitive
:
C3
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
durvalumab
Resistant: C3 – Early Trials
durvalumab
Resistant
:
C3
durvalumab
Resistant: C3 – Early Trials
durvalumab
Resistant
:
C3
EML4-ALK fusion
Ovarian Cancer
EML4-ALK fusion
Ovarian Cancer
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
EML4-ALK fusion
Breast Cancer
EML4-ALK fusion
Breast Cancer
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
EML4-ALK fusion
Lung Adenocarcinoma
EML4-ALK fusion
Lung Adenocarcinoma
Resistant: C4 – Case Studies
Resistant
:
C4
Resistant: C4 – Case Studies
Resistant
:
C4
EML4-ALK fusion
Lung Adenocarcinoma
EML4-ALK fusion
Lung Adenocarcinoma
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
brigatinib
Sensitive: C4 – Case Studies
brigatinib
Sensitive
:
C4
brigatinib
Sensitive: C4 – Case Studies
brigatinib
Sensitive
:
C4
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
EML4-ALK fusion
Neuroendocrine Tumor
EML4-ALK fusion
Neuroendocrine Tumor
lorlatinib
Sensitive: C4 – Case Studies
lorlatinib
Sensitive
:
C4
lorlatinib
Sensitive: C4 – Case Studies
lorlatinib
Sensitive
:
C4
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
atezolizumab
Sensitive: C4 – Case Studies
atezolizumab
Sensitive
:
C4
atezolizumab
Sensitive: C4 – Case Studies
atezolizumab
Sensitive
:
C4
EML4-ALK fusion
Lung Adenocarcinoma
EML4-ALK fusion
Lung Adenocarcinoma
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
EML4-ALK fusion
Neuroendocrine Tumor
EML4-ALK fusion
Neuroendocrine Tumor
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
EML4-ALK fusion
Lung Adenocarcinoma
EML4-ALK fusion
Lung Adenocarcinoma
ensartinib
Sensitive: C4 – Case Studies
ensartinib
Sensitive
:
C4
ensartinib
Sensitive: C4 – Case Studies
ensartinib
Sensitive
:
C4
EML4-ALK fusion
Salivary Gland Cancer
EML4-ALK fusion
Salivary Gland Cancer
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: C4 – Case Studies
Immunotherapy
Sensitive
:
C4
Immunotherapy
Sensitive: C4 – Case Studies
Immunotherapy
Sensitive
:
C4
EML4-ALK fusion
Lung Adenocarcinoma
EML4-ALK fusion
Lung Adenocarcinoma
lorlatinib
Sensitive: C4 – Case Studies
lorlatinib
Sensitive
:
C4
lorlatinib
Sensitive: C4 – Case Studies
lorlatinib
Sensitive
:
C4
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
MTI-31
Sensitive: D – Preclinical
MTI-31
Sensitive
:
D
MTI-31
Sensitive: D – Preclinical
MTI-31
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
ADX-1612
Sensitive: D – Preclinical
ADX-1612
Sensitive
:
D
ADX-1612
Sensitive: D – Preclinical
ADX-1612
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
ceritinib
Sensitive: D – Preclinical
ceritinib
Sensitive
:
D
ceritinib
Sensitive: D – Preclinical
ceritinib
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
ceritinib + U0126
Sensitive: D – Preclinical
ceritinib + U0126
Sensitive
:
D
ceritinib + U0126
Sensitive: D – Preclinical
ceritinib + U0126
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
lorlatinib
Resistant: D – Preclinical
lorlatinib
Resistant
:
D
lorlatinib
Resistant: D – Preclinical
lorlatinib
Resistant
:
D
EML4-ALK fusion
Melanoma
EML4-ALK fusion
Melanoma
crizotinib
Sensitive: D – Preclinical
crizotinib
Sensitive
:
D
crizotinib
Sensitive: D – Preclinical
crizotinib
Sensitive
:
D
EML4-ALK fusion
Melanoma
EML4-ALK fusion
Melanoma
ceritinib
Sensitive: D – Preclinical
ceritinib
Sensitive
:
D
ceritinib
Sensitive: D – Preclinical
ceritinib
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
gilteritinib
Sensitive: D – Preclinical
gilteritinib
Sensitive
:
D
gilteritinib
Sensitive: D – Preclinical
gilteritinib
Sensitive
:
D
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