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BIOMARKER:

EML4-ALK fusion

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Other names: EML4, EMAP Like 4, Restrictedly Overexpressed Proliferation-Associated Protein, Echinoderm Microtubule-Associated Protein-Like 4, Echinoderm Microtubule Associated Protein Like 4, Ropp 120, C2orf2, EMAP-4, EMAPL4, ROPP120, ELP120, NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
EML4-ALK fusion
Non Small Cell Lung Cancer
Tyrosine kinase inhibitor
Resistant
:
C3
EML4-ALK fusion
Non Small Cell Lung Cancer
crizotinib
Resistant
:
C3
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
Tyrosine kinase inhibitor
Sensitive
:
C3
EML4-ALK fusion
Non Small Cell Lung Cancer
alectinib
Sensitive
:
C3
EML4-ALK fusion
Non Small Cell Lung Cancer
durvalumab
Resistant
:
C3
EML4-ALK fusion
Ovarian Cancer
alectinib
Sensitive
:
C4
EML4-ALK fusion
Breast Cancer
crizotinib
Sensitive
:
C4
EML4-ALK fusion
Lung Adenocarcinoma
GC
Resistant
:
C4
EML4-ALK fusion
Lung Adenocarcinoma
crizotinib
Sensitive
:
C4
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
brigatinib
Sensitive
:
C4
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
alectinib
Sensitive
:
C4
EML4-ALK fusion
Neuroendocrine Tumor
lorlatinib
Sensitive
:
C4
EML4-ALK fusion
Non Small Cell Lung Cancer
atezolizumab
Sensitive
:
C4
EML4-ALK fusion
Non Small Cell Lung Cancer
MTI-31
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
ADX-1612
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
ceritinib
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
ceritinib + U0126
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
lorlatinib
Resistant
:
D
EML4-ALK fusion
Melanoma
crizotinib
Sensitive
:
D
EML4-ALK fusion
Melanoma
ceritinib
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
gilteritinib
Sensitive
:
D