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BIOMARKER:
EML4-ALK fusion
i
Other names:
EML4, EMAP Like 4, Restrictedly Overexpressed Proliferation-Associated Protein, Echinoderm Microtubule-Associated Protein-Like 4, Echinoderm Microtubule Associated Protein Like 4, Ropp 120, C2orf2, EMAP-4, EMAPL4, ROPP120, ELP120, NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
;
27436
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
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EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
crizotinib
Resistant: C3 – Early Trials
crizotinib
Resistant
:
C3
crizotinib
Resistant: C3 – Early Trials
crizotinib
Resistant
:
C3
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
alectinib
Sensitive: C3 – Early Trials
alectinib
Sensitive
:
C3
alectinib
Sensitive: C3 – Early Trials
alectinib
Sensitive
:
C3
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
durvalumab
Resistant: C3 – Early Trials
durvalumab
Resistant
:
C3
durvalumab
Resistant: C3 – Early Trials
durvalumab
Resistant
:
C3
EML4-ALK fusion
Ovarian Cancer
EML4-ALK fusion
Ovarian Cancer
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
EML4-ALK fusion
Breast Cancer
EML4-ALK fusion
Breast Cancer
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
EML4-ALK fusion
Lung Adenocarcinoma
EML4-ALK fusion
Lung Adenocarcinoma
Resistant: C4 – Case Studies
Resistant
:
C4
Resistant: C4 – Case Studies
Resistant
:
C4
EML4-ALK fusion
Lung Adenocarcinoma
EML4-ALK fusion
Lung Adenocarcinoma
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
brigatinib
Sensitive: C4 – Case Studies
brigatinib
Sensitive
:
C4
brigatinib
Sensitive: C4 – Case Studies
brigatinib
Sensitive
:
C4
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
EML4-ALK fusion
Lung Non-Small Cell Squamous Cancer
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
EML4-ALK fusion
Neuroendocrine Tumor
EML4-ALK fusion
Neuroendocrine Tumor
lorlatinib
Sensitive: C4 – Case Studies
lorlatinib
Sensitive
:
C4
lorlatinib
Sensitive: C4 – Case Studies
lorlatinib
Sensitive
:
C4
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
atezolizumab
Sensitive: C4 – Case Studies
atezolizumab
Sensitive
:
C4
atezolizumab
Sensitive: C4 – Case Studies
atezolizumab
Sensitive
:
C4
EML4-ALK fusion
Lung Adenocarcinoma
EML4-ALK fusion
Lung Adenocarcinoma
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
EML4-ALK fusion
Neuroendocrine Tumor
EML4-ALK fusion
Neuroendocrine Tumor
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
EML4-ALK fusion
Lung Adenocarcinoma
EML4-ALK fusion
Lung Adenocarcinoma
ensartinib
Sensitive: C4 – Case Studies
ensartinib
Sensitive
:
C4
ensartinib
Sensitive: C4 – Case Studies
ensartinib
Sensitive
:
C4
EML4-ALK fusion
Salivary Gland Cancer
EML4-ALK fusion
Salivary Gland Cancer
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: C4 – Case Studies
Immunotherapy
Sensitive
:
C4
Immunotherapy
Sensitive: C4 – Case Studies
Immunotherapy
Sensitive
:
C4
EML4-ALK fusion
Lung Adenocarcinoma
EML4-ALK fusion
Lung Adenocarcinoma
lorlatinib
Sensitive: C4 – Case Studies
lorlatinib
Sensitive
:
C4
lorlatinib
Sensitive: C4 – Case Studies
lorlatinib
Sensitive
:
C4
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
MTI-31
Sensitive: D – Preclinical
MTI-31
Sensitive
:
D
MTI-31
Sensitive: D – Preclinical
MTI-31
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
ADX-1612
Sensitive: D – Preclinical
ADX-1612
Sensitive
:
D
ADX-1612
Sensitive: D – Preclinical
ADX-1612
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
ceritinib
Sensitive: D – Preclinical
ceritinib
Sensitive
:
D
ceritinib
Sensitive: D – Preclinical
ceritinib
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
ceritinib + U0126
Sensitive: D – Preclinical
ceritinib + U0126
Sensitive
:
D
ceritinib + U0126
Sensitive: D – Preclinical
ceritinib + U0126
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
lorlatinib
Resistant: D – Preclinical
lorlatinib
Resistant
:
D
lorlatinib
Resistant: D – Preclinical
lorlatinib
Resistant
:
D
EML4-ALK fusion
Melanoma
EML4-ALK fusion
Melanoma
crizotinib
Sensitive: D – Preclinical
crizotinib
Sensitive
:
D
crizotinib
Sensitive: D – Preclinical
crizotinib
Sensitive
:
D
EML4-ALK fusion
Melanoma
EML4-ALK fusion
Melanoma
ceritinib
Sensitive: D – Preclinical
ceritinib
Sensitive
:
D
ceritinib
Sensitive: D – Preclinical
ceritinib
Sensitive
:
D
EML4-ALK fusion
Non Small Cell Lung Cancer
EML4-ALK fusion
Non Small Cell Lung Cancer
gilteritinib
Sensitive: D – Preclinical
gilteritinib
Sensitive
:
D
gilteritinib
Sensitive: D – Preclinical
gilteritinib
Sensitive
:
D
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