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BIOMARKER:
EGFR mutation + PIK3CA mutation
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor, PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alph
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Entrez ID:
1956
;
5290
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
EGFR exon 19 deletion (79)
EGFR amplification (52)
PIK3CA amplification (12)
EGFR exon 18 deletion (3)
EGFR exon 2-7 deletion + EGFR amplification (2)
EGFR amplification + ERBB2 amplification (1)
EGFR exon 19 deletion + HER-2 amplification (1)
EGFR exon 21 deletion (1)
EGFR T790M + exon 19 deletion (0)
EGFR amplifcation (0)
EGFR exon 19 deletion (79)
EGFR amplification (52)
PIK3CA amplification (12)
EGFR exon 18 deletion (3)
EGFR exon 2-7 deletion + EGFR amplification (2)
EGFR amplification + ERBB2 amplification (1)
EGFR exon 19 deletion + HER-2 amplification (1)
EGFR exon 21 deletion (1)
EGFR T790M + exon 19 deletion (0)
EGFR amplifcation (0)
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News
Trials
VERI cancer hierarchy
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EGFR mutation + PIK3CA mutation
Lung Adenocarcinoma
EGFR mutation + PIK3CA mutation
Lung Adenocarcinoma
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
EGFR mutation + PIK3CA mutation
Non Small Cell Lung Cancer
EGFR mutation + PIK3CA mutation
Non Small Cell Lung Cancer
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
EGFR mutation + PIK3CA mutation
Non Small Cell Lung Cancer
EGFR mutation + PIK3CA mutation
Non Small Cell Lung Cancer
aumolertinib
Sensitive: C3 – Early Trials
aumolertinib
Sensitive
:
C3
aumolertinib
Sensitive: C3 – Early Trials
aumolertinib
Sensitive
:
C3
EGFR mutation + PIK3CA mutation
Lung Adenocarcinoma
EGFR mutation + PIK3CA mutation
Lung Adenocarcinoma
aumolertinib
Sensitive: C4 – Case Studies
aumolertinib
Sensitive
:
C4
aumolertinib
Sensitive: C4 – Case Studies
aumolertinib
Sensitive
:
C4
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