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BIOMARKER:
EGFR L858R + EGFR T790M
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor
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Entrez ID:
1956
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
EGFR exon 19 deletion (79)
EGFR amplification (52)
EGFR exon 18 deletion (3)
EGFR exon 2-7 deletion + EGFR amplification (2)
EGFR amplification + ERBB2 amplification (1)
EGFR exon 19 deletion + HER-2 amplification (1)
EGFR exon 21 deletion (1)
EGFR T790M + exon 19 deletion (0)
EGFR amplifcation (0)
EGFR exon 19 deletion (79)
EGFR amplification (52)
EGFR exon 18 deletion (3)
EGFR exon 2-7 deletion + EGFR amplification (2)
EGFR amplification + ERBB2 amplification (1)
EGFR exon 19 deletion + HER-2 amplification (1)
EGFR exon 21 deletion (1)
EGFR T790M + exon 19 deletion (0)
EGFR amplifcation (0)
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Associations
News
Trials
VERI cancer hierarchy
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EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
osimertinib
Sensitive: A2 - Guideline
osimertinib
Sensitive
:
A2
osimertinib
Sensitive: A2 - Guideline
osimertinib
Sensitive
:
A2
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
osimertinib + afatinib
Sensitive: B - Late Trials
osimertinib + afatinib
Sensitive
:
B
osimertinib + afatinib
Sensitive: B - Late Trials
osimertinib + afatinib
Sensitive
:
B
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
erlotinib
Resistant: C3 – Early Trials
erlotinib
Resistant
:
C3
erlotinib
Resistant: C3 – Early Trials
erlotinib
Resistant
:
C3
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
afatinib
Sensitive: C3 – Early Trials
afatinib
Sensitive
:
C3
afatinib
Sensitive: C3 – Early Trials
afatinib
Sensitive
:
C3
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
gefitinib
Resistant: C3 – Early Trials
gefitinib
Resistant
:
C3
gefitinib
Resistant: C3 – Early Trials
gefitinib
Resistant
:
C3
EGFR L858R + EGFR T790M
Lung Non-Small Cell Squamous Cancer
EGFR L858R + EGFR T790M
Lung Non-Small Cell Squamous Cancer
gefitinib
Resistant: C4 – Case Studies
gefitinib
Resistant
:
C4
gefitinib
Resistant: C4 – Case Studies
gefitinib
Resistant
:
C4
EGFR L858R + EGFR T790M
Lung Adenocarcinoma
EGFR L858R + EGFR T790M
Lung Adenocarcinoma
aumolertinib
Sensitive: C4 – Case Studies
aumolertinib
Sensitive
:
C4
aumolertinib
Sensitive: C4 – Case Studies
aumolertinib
Sensitive
:
C4
EGFR L858R + EGFR T790M
Lung Cancer
EGFR L858R + EGFR T790M
Lung Cancer
osimertinib
Sensitive: C4 – Case Studies
osimertinib
Sensitive
:
C4
osimertinib
Sensitive: C4 – Case Studies
osimertinib
Sensitive
:
C4
EGFR L858R + EGFR T790M
Lung Adenocarcinoma
EGFR L858R + EGFR T790M
Lung Adenocarcinoma
gefitinib
Resistant: D – Preclinical
gefitinib
Resistant
:
D
gefitinib
Resistant: D – Preclinical
gefitinib
Resistant
:
D
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
CH7233163
Sensitive: D – Preclinical
CH7233163
Sensitive
:
D
CH7233163
Sensitive: D – Preclinical
CH7233163
Sensitive
:
D
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
rociletinib
Sensitive: D – Preclinical
rociletinib
Sensitive
:
D
rociletinib
Sensitive: D – Preclinical
rociletinib
Sensitive
:
D
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
osimertinib + BX795
Sensitive: D – Preclinical
osimertinib + BX795
Sensitive
:
D
osimertinib + BX795
Sensitive: D – Preclinical
osimertinib + BX795
Sensitive
:
D
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
H002
Sensitive: D – Preclinical
H002
Sensitive
:
D
H002
Sensitive: D – Preclinical
H002
Sensitive
:
D
EGFR L858R + EGFR T790M
Lung Cancer
EGFR L858R + EGFR T790M
Lung Cancer
osimertinib + tipifarnib
Sensitive: D – Preclinical
osimertinib + tipifarnib
Sensitive
:
D
osimertinib + tipifarnib
Sensitive: D – Preclinical
osimertinib + tipifarnib
Sensitive
:
D
EGFR L858R + EGFR T790M
Melanoma
EGFR L858R + EGFR T790M
Melanoma
doxorubicin hydrochloride
Resistant: D – Preclinical
doxorubicin hydrochloride
Resistant
:
D
doxorubicin hydrochloride
Resistant: D – Preclinical
doxorubicin hydrochloride
Resistant
:
D
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
KKI04
Sensitive: D – Preclinical
KKI04
Sensitive
:
D
KKI04
Sensitive: D – Preclinical
KKI04
Sensitive
:
D
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