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DRUG:
birabresib (OTX015)
i
Other names:
OTX105, OTX 015, MK8628, OTX-015, OTX015, Y-803, MK 8628, MK-8628
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News alerts, weekly reports and conference planners
Associations
(10)
News
Trials
Company:
Merck (MSD)
Drug class:
BRD4 inhibitor, BRD2 inhibitor, BRD3 inhibitor
Related drugs:
‹
BI2536 (3)
SRA515 (3)
GS-626510 (2)
I-BET151 (2)
PLX51107 (2)
SRX3262 (1)
ARV-825 (0)
HH3806 (0)
NEO1132 (0)
NHWD-870 (0)
NUV-868 (0)
OPN-2853 (0)
PH-3861 (0)
PH-894 (0)
SF1126 (0)
SF2523 (0)
SF2535 (0)
SRX3177 (0)
BI2536 (3)
SRA515 (3)
GS-626510 (2)
I-BET151 (2)
PLX51107 (2)
SRX3262 (1)
ARV-825 (0)
HH3806 (0)
NEO1132 (0)
NHWD-870 (0)
NUV-868 (0)
OPN-2853 (0)
PH-3861 (0)
PH-894 (0)
SF1126 (0)
SF2523 (0)
SF2535 (0)
SRX3177 (0)
›
Associations
(10)
News
Trials
VERI cancer hierarchy
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MLL translocation
Acute Myelogenous Leukemia
MLL translocation
Acute Myelogenous Leukemia
OTX015
Resistant: C3 – Early Trials
OTX015
Resistant
:
C3
OTX015
Resistant: C3 – Early Trials
OTX015
Resistant
:
C3
SPI1 deletion
Acute Myelogenous Leukemia
SPI1 deletion
Acute Myelogenous Leukemia
OTX015
Sensitive: C3 – Early Trials
OTX015
Sensitive
:
C3
OTX015
Sensitive: C3 – Early Trials
OTX015
Sensitive
:
C3
MTHFR underexpression
Acute Myelogenous Leukemia
MTHFR underexpression
Acute Myelogenous Leukemia
OTX015
Sensitive: C3 – Early Trials
OTX015
Sensitive
:
C3
OTX015
Sensitive: C3 – Early Trials
OTX015
Sensitive
:
C3
MYCN amplification
Neuroblastoma
MYCN amplification
Neuroblastoma
OTX015
Sensitive: D – Preclinical
OTX015
Sensitive
:
D
OTX015
Sensitive: D – Preclinical
OTX015
Sensitive
:
D
TERT rearrangement
Neuroblastoma
TERT rearrangement
Neuroblastoma
OTX015
Sensitive: D – Preclinical
OTX015
Sensitive
:
D
OTX015
Sensitive: D – Preclinical
OTX015
Sensitive
:
D
NPM1 mutation
Acute Myelogenous Leukemia
NPM1 mutation
Acute Myelogenous Leukemia
KO-539 + OTX015
Sensitive: D – Preclinical
KO-539 + OTX015
Sensitive
:
D
KO-539 + OTX015
Sensitive: D – Preclinical
KO-539 + OTX015
Sensitive
:
D
MLL mutation
Acute Myelogenous Leukemia
MLL mutation
Acute Myelogenous Leukemia
KO-539 + OTX015
Sensitive: D – Preclinical
KO-539 + OTX015
Sensitive
:
D
KO-539 + OTX015
Sensitive: D – Preclinical
KO-539 + OTX015
Sensitive
:
D
ARID1A mutation
Bladder Cancer
ARID1A mutation
Bladder Cancer
OTX015
Sensitive: D – Preclinical
OTX015
Sensitive
:
D
OTX015
Sensitive: D – Preclinical
OTX015
Sensitive
:
D
Chr inv(3)t(3;3) + MECOM overexpression
Acute Myelogenous Leukemia
Chr inv(3)t(3;3) + MECOM overexpression
Acute Myelogenous Leukemia
OTX015 + BC2059
Sensitive: D – Preclinical
OTX015 + BC2059
Sensitive
:
D
OTX015 + BC2059
Sensitive: D – Preclinical
OTX015 + BC2059
Sensitive
:
D
FLT3-ITD mutation + NPM1 mutation
Acute Myelogenous Leukemia
FLT3-ITD mutation + NPM1 mutation
Acute Myelogenous Leukemia
OTX015 + FHD-286
Sensitive: D – Preclinical
OTX015 + FHD-286
Sensitive
:
D
OTX015 + FHD-286
Sensitive: D – Preclinical
OTX015 + FHD-286
Sensitive
:
D
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