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    Association details:
    Biomarker:SPI1 deletion
    Cancer:Acute Myelogenous Leukemia
    Drug:birabresib (OTX015) (BRD4 inhibitor, BRD2 inhibitor, BRD3 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    ASH 2019
    Title:

    The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

    Published date:
    11/06/2019
    Excerpt:
    SPI1 knockdown significantly reduced the resistance to OTX015 of AML cells whose MTHFR expression was suppressed or MLL-AF9-transformed Mthfr knockout primary murine cells.
    DOI:
    https://doi.org/10.1182/blood-2019-131255