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Association details:
| Biomarker: | ARID1A mutation |
|---|---|
| Cancer: | Bladder Cancer |
| Drug: | birabresib (OTX015) (BRD4 inhibitor, BRD2 inhibitor, BRD3 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
3267 / 9 - ARID1A mutated bladder cancer cells are sensitized to BET protein inhibition with OTX-015
Published date:
03/09/2022
Excerpt:
...we tested the hypothesis that ARID1Amut cells are particularly sensitized to the pan-BET inhibitor OTX-015….OTX-015 was 8-times more potent in ARID1A mut HT1197 cells at 120 h than in ARID1AWT 5637 cells (IC50: 0.12 μM vs. 1.0 μM).
