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Association details:
| Biomarker: | MYCN amplification |
|---|---|
| Cancer: | Neuroblastoma |
| Drug: | birabresib (OTX015) (BRD4 inhibitor, BRD2 inhibitor, BRD3 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition
Excerpt:
...mouse xenograft model of MYCN-amplified human neuroblastoma, with the human IMR-5 cell line. Average tumor volume was significantly smaller in the OTX015 groups compared with control mice after day 9 of treatment...OTX015 showed therapeutic efficacy against preclinical MYCN-driven neuroblastoma models…
DOI:
10.1158/1078-0432.CCR-15-1449
