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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

Targeted Therapy of TERT-Rearranged Neuroblastoma with BET Bromodomain Inhibitor and Proteasome Inhibitor Combination Therapy

Excerpt:
In mice xenografted with TERT-rearranged neuroblastoma cell lines or PDX tumor cells, OTX015 and carfilzomib...induced tumor cell apoptosis, suppressed tumor progression, and improved mouse survival…
Secondary therapy:
carfilzomib
DOI:
10.1158/1078-0432.CCR-20-3044