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Association details:
| Biomarker: | TERT rearrangement |
|---|---|
| Cancer: | Neuroblastoma |
| Drug: | birabresib (OTX015) (BRD4 inhibitor, BRD2 inhibitor, BRD3 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targeted Therapy of TERT-Rearranged Neuroblastoma with BET Bromodomain Inhibitor and Proteasome Inhibitor Combination Therapy
Excerpt:
In mice xenografted with TERT-rearranged neuroblastoma cell lines or PDX tumor cells, OTX015 and carfilzomib...induced tumor cell apoptosis, suppressed tumor progression, and improved mouse survival…
Secondary therapy:
carfilzomib
DOI:
10.1158/1078-0432.CCR-20-3044
