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BIOMARKER:
MYC rearrangement + BCL2 rearrangement
i
Other names:
MYC, bHLHe39, c-Myc, MYCC, V-myc avian myelocytomatosis viral oncogene homolog, BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2
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Entrez ID:
4609
;
596
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
MYC rearrangement + BCL6 rearrangement (9)
MYC rearrangement (7)
MYC rearrangement + BCL2 rearrangement + BCL6 rearrangement (6)
BCL2 mutation (6)
MYC mutation (5)
MYC translocation (4)
BCL2 G101V (4)
MYC translocation + BCL2 translocation (3)
BCL2 rearrangement (3)
BCL2 D103Y (2)
EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)
MYC translocation + BCL6 translocation (1)
MYC translocation + BCL6 translocation + BCL2 translocation (1)
BCL2 F104I (1)
BCL2 G101V + SF3B1 mutation (1)
BCL2 N103E (1)
BCL2 N103Y (1)
BCL2 N107_N110dup (1)
BCL2 V156N (1)
EZH2 mutation + BCL2 translocation (1)
TP53 mutation + BCL2 rearrangement (1)
MYC rearrangement + BCL2 rearrangement+ BCL6 rearrangement (0)
BCL2 translocation (0)
MYC rearrangement + BCL6 rearrangement (9)
MYC rearrangement (7)
MYC rearrangement + BCL2 rearrangement + BCL6 rearrangement (6)
BCL2 mutation (6)
MYC mutation (5)
MYC translocation (4)
BCL2 G101V (4)
MYC translocation + BCL2 translocation (3)
BCL2 rearrangement (3)
BCL2 D103Y (2)
EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)
MYC translocation + BCL6 translocation (1)
MYC translocation + BCL6 translocation + BCL2 translocation (1)
BCL2 F104I (1)
BCL2 G101V + SF3B1 mutation (1)
BCL2 N103E (1)
BCL2 N103Y (1)
BCL2 N107_N110dup (1)
BCL2 V156N (1)
EZH2 mutation + BCL2 translocation (1)
TP53 mutation + BCL2 rearrangement (1)
MYC rearrangement + BCL2 rearrangement+ BCL6 rearrangement (0)
BCL2 translocation (0)
›
Associations
(22)
News
Trials
Search handles
@AaronGoodman33
Search handles
@AaronGoodman33
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Latest
almost2years
Double Hit (DH) vs Expressor DLBCL (DE) DE = IHC MYC+(>40%), BCL2+(>50%) ABC>GCB Bad Rx = RCHOP DH = FISH MYC+BCL2 and/or BCL6 rearrangement GCB>ABC Very bad (esp MYC+IG partner) Rx = DA-EPOCH-R? DH gene sig = RNA 50% negative for MYC+BCL2 rearrangement Very bad Rx = ??? (@AaronGoodman33)
almost 2 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
|
MYC rearrangement + BCL2 rearrangement • MYC rearrangement • BCL6 rearrangement • BCL2 rearrangement
|
Rituxan (rituximab)
over2years
Double Hit (DH) vs Expressor DLBCL (DE) DE = IHC MYC+(>40%), BCL2+(>50%) ABC>GCB Bad Rx = RCHOP DH = FISH MYC+BCL2 and/or BCL6 rearrangement GCB>ABC Very bad (esp MYC+IG) Rx = RCHOP or DA-EPOCH-R? DH gene sig = RNA 50% negative for MYC+BCL2 rearrangement Very bad Rx = ??? (@AaronGoodman33)
over 2 years ago
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
|
MYC rearrangement + BCL2 rearrangement • MYC rearrangement • BCL6 rearrangement • BCL2 rearrangement
|
Rituxan (rituximab)
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