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BIOMARKER:
BRCA1 expression
i
Other names:
BRCA1, BRCC1, PPP1R53, RNF53, Breast cancer 1, early onset
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Entrez ID:
672
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
BRCA1 mutation (196)
BRCA wild-type (19)
BRCA1 2110_2111delAA + BRCA1 4071_4096 +14del40 + TP53 R342P + NOTCH2 Q1310H (7)
BRCA1 mutation + BRCA2 mutation (4)
BRCA1 L1780P (2)
BRCA1 R1443* (2)
BRCA1 mutation + TP53 mutation (2)
EGFR mutation + TP53 mutation + BRCA1 mutation (2)
BRCA1 2080delA (1)
BRCA1 307 T> A (L63*) (1)
BRCA1 3363delGAAA (1)
BRCA1 5396insC (1)
BRCA1 E1446* (1)
BRCA1 N1018fs*8 (1)
BRCA1 Q858 (1)
BRCA1 S451Lfs*20 (1)
BRCA1 biallelic inactivation (1)
BRCA1 mutation + ATM mutation (1)
BRCA1 mutation + TP53 R248Q (1)
BRCA1 rearrangement (1)
MSH2 mutation + MSH6 mutation + BRCA1 mutation (1)
BRCA1 mutation (196)
BRCA wild-type (19)
BRCA1 2110_2111delAA + BRCA1 4071_4096 +14del40 + TP53 R342P + NOTCH2 Q1310H (7)
BRCA1 mutation + BRCA2 mutation (4)
BRCA1 L1780P (2)
BRCA1 R1443* (2)
BRCA1 mutation + TP53 mutation (2)
EGFR mutation + TP53 mutation + BRCA1 mutation (2)
BRCA1 2080delA (1)
BRCA1 307 T> A (L63*) (1)
BRCA1 3363delGAAA (1)
BRCA1 5396insC (1)
BRCA1 E1446* (1)
BRCA1 N1018fs*8 (1)
BRCA1 Q858 (1)
BRCA1 S451Lfs*20 (1)
BRCA1 biallelic inactivation (1)
BRCA1 mutation + ATM mutation (1)
BRCA1 mutation + TP53 R248Q (1)
BRCA1 rearrangement (1)
MSH2 mutation + MSH6 mutation + BRCA1 mutation (1)
›
Associations
(3)
News
Trials
Search handles
@Dr_Ivanoncologo
@cancerassassin1
@weldeiry
Search handles
@Dr_Ivanoncologo
@cancerassassin1
@weldeiry
Filter by
Latest
almost2years
Have read some data suggesting correlation b/w ⬇️ Vit D & breast cancer, not TNBC specific. Also, could you provide more detail about “p53 functions which trigger eventual BRCA1 expression?” Research articles/study links? Thanks! (@JaniceTNBCmets)
almost 2 years ago
BRCA1 (Breast cancer 1, early onset)
|
BRCA1 expression
almost2years
Significant vitamin d deficiency at dx and prior five years super common in my clients w/TNBC sans BRCA1 mutation. VDR needed for important P53 functions which trigger eventual BRCA1 expression. Sure wish we could know D levels in the controls that respond to PARPi. Low? (@nursekristinrn)
almost 2 years ago
BRCA1 (Breast cancer 1, early onset)
|
TP53 mutation • BRCA1 mutation • BRCA1 expression
almost2years
An interesting study shows that patients with mt KRAS #NSCLC could benefit from a #KRAS-targeted treatment strategy in combination with #therapeutic agents based on #markers such as #SRC and #BRCA1 expression levels. @LungCancerDr @Lungsolutions https://t.co/9SKipnlcA6 (@Dr_Ivanoncologo)
almost 2 years ago
Clinical • Combination therapy
|
KRAS (KRAS proto-oncogene GTPase) • BRCA1 (Breast cancer 1, early onset)
|
BRCA1 expression
over2years
Original paper in @Oncotarget from Leaf et al @weldeiry lab: Opposing effects of BRCA1 mRNA expression on patient survival in breast and colorectal cancer and variations among African American, Asian, and younger patients https://t.co/duCkThZ2s7 #bcsm #crcsm #healthdisparities (@cancerassassin1)
over 2 years ago
Clinical
|
BRCA1 (Breast cancer 1, early onset)
|
BRCA1 expression
over2years
News Release @Oncotarget: BRCA1 mRNA expression in breast and colorectal cancer https://t.co/ste3sae9zi #eldeirylab @BrownMedicine @BrownUCancer @BrownPathology @BrownUniversity @BrownUPathoGP (@weldeiry)
over 2 years ago
BRCA1 (Breast cancer 1, early onset)
|
BRCA1 expression
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