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    almost2years
    Correlation of ROS1 (D4D6) Immunohistochemistry with ROS1 Fluorescence In Situ Hybridization Assay in a Contemporary Cohort of Pulmonary Adenocarcinomas. (PubMed, South Asian J Cancer)
    Conclusion   ROS1 IHC has high sensitivity at a cost of lower specificity for the detection of ROS1 gene rearrangement. All IHC positive cases should undergo a confirmatory FISH test as this testing algorithm stands as a reliable and economic tool to screen ROS1 rearrangement in lung adenocarcinomas.
    Journal
    |
    ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
    |
    ROS1 positive • ROS1 rearrangement
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    Vysis ROS1 Break Apart FISH Probe Kit
    3years
    Different Prevalence of Molecular Alterations for Non-Small Cell Lung Cancer in Mexican Cohort of 200 Patients (USCAP 2022)
    "Three differences of prevalence are observed in our study for mexican population with lung AC: EGFR 32.7%, 13.9% KRAS and ALK 6.7%. According to recent NGS studies in Mexico, EGFR has a prevalence of 36.7% and 20% for KRAS. In Mexico and Latin America (LA) the mutational frequency is inverse compared to Caucasian population, with KRAS (20-25%) being more frequent than EGFR (10-15%) and ALK (4.5-5%)."
    Clinical
    |
    EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1) • KRAS (KRAS proto-oncogene GTPase) • ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
    |
    PD-L1 expression • KRAS mutation • EGFR mutation • ROS1 fusion • ALK-ROS1 fusion
    |
    VENTANA PD-L1 (SP263) Assay • therascreen® EGFR RGQ PCR Kit • therascreen® KRAS RGQ PCR Kit • Vysis ALK Break Apart FISH Probe Kit • Vysis ROS1 Break Apart FISH Probe Kit