^
    over2years
    DOUBLE-HIT TRAF3 DELETION AND MUTATION IDENTIFIED BY HIGH-THROUGHPUT SEQUENCING DEFINE A NEW INDEPENDENT PROGNOSTIC FACTOR IN CHRONIC LYMPHOCYTIC LEUKEMIA (EHA 2022)
    Conclusion Our work demonstrates that TRAF3 mutations and deletions are highly enriched in CLL patients with del-3’IGH, resulting in the biallelic inactivation of this gene. The presence of this double-hit on TRAF3 worsen the prognosis of CLL patients, being and independent prognostic factor with similar impact on TFT than the biallelic loss of TP53 .
    TP53 (Tumor protein P53) • NOTCH1 (Notch 1) • CD19 (CD19 Molecule) • IGH (Immunoglobulin Heavy Locus)
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    ATM mutation • Chr del(11q) • IGH translocation
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    Vysis CLL FISH Probe Kit