Thyroid GuidePx® is a prognostic test that helps surgeons and endocrinologists to make important decisions on the clinical management of papillary thyroid cancer. Thyroid GuidePx® is performed on next generation sequencing (RNASeq). The test provides a molecular sub-classification of papillary thyroid cancer that is based on the expression of 82 genes. Thyroid GuidePx® simplifies prognostication, and identifies a low risk group with <5% recurrence rate.