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    DRUG:

    Zoptrex (zoptarelin doxorubicin)

    i
    Other names: doxorubicin-GnRH agonist conjugate, D-81858, ZEN-008, AEZS 108, AEZS-108, AN-152
    Company:
    AEterna Zentaris
    Drug class:
    Topoisomerase II inhibitor
    Related drugs:
    almost5years
    The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma. (PubMed, Oncotarget)
    AEZS-108 is a hybrid molecule, composed of a synthetic peptide carrier and the cytotoxic doxorubicin (DOX). In conclusion, we show for the first time that AEZS-108 has a major impact in the regulation of angiogenesis thus plays a potential role in tumor suppression. Taken together, our results support the development of novel therapeutic strategies for UM focusing on LHRH receptors.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    doxorubicin hydrochloride • Zoptrex (zoptarelin doxorubicin)