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DRUG:

Vumon (teniposide)

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Company:

BMS

Drug class:

Topoisomerase II inhibitor

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pegylated liposomal doxorubicin (1)

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lyso-thermosensitive liposomal doxorubicin (0)

tirapazamine (0)

dexrazoxane (0)

doxorubicin liposomal (0)

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TOP2A overexpression	Adrenal Cortex Carcinoma	TOP2A overexpression	Adrenal Cortex Carcinoma	teniposide Sensitive: D – Preclinical teniposide Sensitive : D	teniposide Sensitive: D – Preclinical teniposide Sensitive : D
IDH2 mutation	Glioma	IDH2 mutation	Glioma	teniposide Sensitive: D – Preclinical teniposide Sensitive : D	teniposide Sensitive: D – Preclinical teniposide Sensitive : D
IDH1 mutation	Glioma	IDH1 mutation	Glioma	teniposide Sensitive: D – Preclinical teniposide Sensitive : D	teniposide Sensitive: D – Preclinical teniposide Sensitive : D
TOP2A overexpression	Rectal Cancer	TOP2A overexpression	Rectal Cancer	teniposide Resistant: D – Preclinical teniposide Resistant : D	teniposide Resistant: D – Preclinical teniposide Resistant : D
TOP2A amplification	Rectal Cancer	TOP2A amplification	Rectal Cancer	teniposide Resistant: D – Preclinical teniposide Resistant : D	teniposide Resistant: D – Preclinical teniposide Resistant : D