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DRUG:

TST005

i
Other names: TST005
Associations
Trials
Company:
Transcenta
Drug class:
PD-L1 inhibitor, TGF-β R2 kinase inhibitor
Related drugs:
Associations
Trials
1year
Study of TST005 in Patients With Locally Advanced or Metastatic Solid Tumors (clinicaltrials.gov)
P1, N=19, Terminated, Suzhou Transcenta Therapeutics Co., Ltd. | N=55 --> 19 | Trial completion date: Dec 2023 --> Sep 2023 | Active, not recruiting --> Terminated | Trial primary completion date: Dec 2023 --> Sep 2023; Corporate Decision
Enrollment change • Trial completion date • Trial termination • Trial primary completion date • Metastases
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TST005
over2years
TST005, a bifunctional fusion protein of PD-L1/TGF-βRII, demonstrates potent anti-tumor activities with good safety profiles (AACR 2022)
Here we report TST005 anti-tumor activities in MC38 colorectal cancer and EMT-6 breast cancer models compared to M7824 (Merck’s PD-L1/TGF-βRII) analog and its safety profiles following single or repeated doses in rats and non-human primates (NHP). Based on the exposure of TST005 in monkeys and predicted exposure at First in Human (FIH) dose, the safety margin of TST005 will be higher than 200 and 500 folds calculated on Cmax and AUC respectively. In conclusion, we have demonstrated the antitumor activity of TST005 in PD/PD-L1 sensitive and resistant tumor models as well as the safety profile in NHP, TST005 has been granted for phase 1 clinical trials in USA (NCT04958434).
Clinical • PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1) • TGFB1 (Transforming Growth Factor Beta 1)
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PD-L1 expression
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bintrafusp alfa (M7824) • TST005
over3years
[VIRTUAL] The preclinical characterization of TST005, a bi-functional anti-PD-L1 and TGF-β trap fusion protein (AACR 2021)
In conclusion, we have demonstrated that TST005 has enhanced immunomodulatory properties and can induce potent antitumor activity in preclinical tumor models that are not sensitive to PD-1/PD-L1 monotherapy. These results provide the rationale for further clinical evaluation of TST005 in patients with advanced solid tumors and less optimal response to first generation PD(L)-1 based immunotherapy.
Preclinical • PD(L)-1 Biomarker • IO biomarker
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TGFB1 (Transforming Growth Factor Beta 1)
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PD-L1 expression
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TST005