T Cell Non-Hodgkin Lymphoma

P2, N=31, Not yet recruiting, Ruijin Hospital

P1, N=20, Not yet recruiting, City of Hope Medical Center

Altogether, these findings were insufficient to establish a diagnosis of pcGDTCL. We review the clinical, histopathologic, and molecular sequencing data pertaining to our rare patient as well as the recent literature on indolent CD30+LPD with gamma-delta T-cells.

AITL with HRS-like cells is prone to misdiagnosis as CHL due to overlapping morphological and immunophenotypic features. Integration of EBER, TCR/IG clonality assessment, and molecular profiling, particularly the identification of TET2 and RHOA mutations is essential for accurate classification. Recognizing this entity is critical for avoiding diagnostic pitfalls and guiding appropriate therapeutic strategies.

In order to improve the efficacy, recent studies have confirmed that the combination of etoposide (CHOPE regimen) on the basis of CHOP regimen can significantly improve the treatment response for newly diagnosed patients aged ≤ 65 years...The patient received four cycles of CHOPE regimen after surgical resection of the primary tumor and underwent PET/CT mid-term evaluation. Through this case, we aim to further explore the pathological diagnosis difficulties of such rare cases and preliminarily evaluate the clinical application value of CHOPE regimen.

A trial of flucloxacillin produced no improvement, and an urgent ultrasound revealed nonspecific skin thickening, prompting a skin biopsy...In this case, the absence of systemic involvement on imaging and the atypical immuno-phenotypic features underscore the complexity of distinguishing between tumour-stage MF and PCGDTCL. This case highlights the role of detailed histopathological evaluation of rare cutaneous lymphomas and emphasizes the need for a multidisciplinary approach to design both local and systemic treatment strategies for individual patients.

Treatment with gemcitabine and oxaliplatin chemotherapy showed significant improvement, complemented by radiotherapy for refractory lesions. Histopathological evaluation and EBV testing are critical for differentiation from other conditions. While initial responses to chemoradiotherapy are promising, recurrence remains common, highlighting the need for vigilant follow-up and optimized therapeutic strategies.

P2, N=39, Not yet recruiting, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

P2, N=37, Not yet recruiting, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Our new unique mouse model will allow further studies of the effects of Trp53 nonsense mutation in a multi-organ system and serve as a model for the Li-Fraumeni syndrome (LFS). It will also be valuable for preclinical evaluation of novel therapeutic strategies for targeting TP53 nonsense mutations in cancer.

The patient underwent five cycles of intravitreal methotrexate for presumed uveal lymphoma involving the ciliary body with pseudo-keratic precipitates before a nasal biopsy confirmed recurrent ENKL...The IL-10/IL-6 ratio is of limited value in the diagnosis of T-cell lymphoma affecting intraocular structures. This case highlights the critical role of UBM in identifying ciliary body involvement of intraocular malignancies.

Despite aggressive therapy, the patient died 21 months after diagnosis. This case delineates the importance of early biopsy, integration of molecular studies, and the urgent need for therapies to improve outcomes in this aggressive lymphoma.