T Cell Non-Hodgkin Lymphoma

Treatment with high-dose prednisolone and ciclosporin led to complete remission...SPTCL should be considered in children with panniculitis nodules unresponsive to antibiotics, but distinction from lupus erythematosus profundus and infection remains a critical diagnostic pitfall. Accurate diagnosis and management require multidisciplinary input, highlighting the importance of an MDT approach in such complex paediatric cases.

P1/2, N=43, Not yet recruiting, Sun Yet-Sen University Cancer Center

P2, N=18, Recruiting, University of Washington | Not yet recruiting --> Recruiting

P2, N=31, Not yet recruiting, Miltenyi Biomedicine GmbH

P1/2, N=43, Suspended, SymBio Pharmaceuticals | Recruiting --> Suspended

Despite partial responses to topical therapies, oral prednisone, and methotrexate, the disease persisted, highlighting therapeutic challenges. This case underscores the importance of molecular profiling in PCAECTCL and suggests potential utility for JAK inhibitors like ruxolitinib.

RNA-seq results showed that the combined therapeutic approach synergistically reduces cell viability and promotes apoptosis through the inhibition of the MYC signaling pathway. Everolimus-gemcitabine combination exhibits synergistic antitumor activity, offering a potential therapeutic strategy for R/R PTCL.

P2, N=31, Not yet recruiting, Ruijin Hospital

P1, N=20, Not yet recruiting, City of Hope Medical Center

Altogether, these findings were insufficient to establish a diagnosis of pcGDTCL. We review the clinical, histopathologic, and molecular sequencing data pertaining to our rare patient as well as the recent literature on indolent CD30+LPD with gamma-delta T-cells.

AITL with HRS-like cells is prone to misdiagnosis as CHL due to overlapping morphological and immunophenotypic features. Integration of EBER, TCR/IG clonality assessment, and molecular profiling, particularly the identification of TET2 and RHOA mutations is essential for accurate classification. Recognizing this entity is critical for avoiding diagnostic pitfalls and guiding appropriate therapeutic strategies.

In order to improve the efficacy, recent studies have confirmed that the combination of etoposide (CHOPE regimen) on the basis of CHOP regimen can significantly improve the treatment response for newly diagnosed patients aged ≤ 65 years...The patient received four cycles of CHOPE regimen after surgical resection of the primary tumor and underwent PET/CT mid-term evaluation. Through this case, we aim to further explore the pathological diagnosis difficulties of such rare cases and preliminarily evaluate the clinical application value of CHOPE regimen.