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DRUG:

IMC-001

i
Other names: STI3031, STIA1015, IMC-001, STI-3031, IMC 001, STI-A1015, IMC001, STI 3031, STI A1015
Associations
Company:
Immuneoncia Therap
Drug class:
PD-L1 inhibitor
Related drugs:
Associations
7ms
New P2 trial • Metastases
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IMC-001
7ms
A Study of IMC-001 in Subjects With Relapsed or Refractory Extranodal NK/T Cell Lymphoma, Nasal Type (clinicaltrials.gov)
P2, N=23, Active, not recruiting, ImmuneOncia Therapeutics Inc. | Recruiting --> Active, not recruiting | Trial completion date: Jun 2026 --> Feb 2026 | Trial primary completion date: Dec 2023 --> Jul 2024
Enrollment closed • Trial completion date • Trial primary completion date
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IMC-001
11ms
Intra-Lymphatic STI-3031 Using the Sofusa DoseConnect Device for Treatment of In-Transit Melanoma, The Sofusa-2 Study (clinicaltrials.gov)
P1, N=3, Active, not recruiting, Mayo Clinic | Recruiting --> Active, not recruiting | N=18 --> 3
Enrollment closed • Enrollment change
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IMC-001
over1year
Balance of CD36+ and CD16+ monocytes controls TLR-mediated cytokine release syndrome and MHC-dependent antitumor responses in EpCAM CAR T cell therapy for gastrointestinal cancers (ESMO 2023)
Clinical trial identification The study had a classic 3+3 design for each indication trial, with separate EpCAM CAR-T cell (IMC001) dose escalations for monotherapy...Conclusions We present valuable insights into the pathophysiology of CRS and suggest that TLR4 on CD36+ monocytes is a promising target for managing CRS, which offers a new strategy for mitigating the side effects of CAR-T therapy. We also highlight the role of innate immune components, particularly CD16+ monocytes, in achieving optimal CAR-T treatment efficacy through antigen processing and presentation.
CAR T-Cell Therapy
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CD36 (thrombospondin receptor) • EPCAM (Epithelial cell adhesion molecule) • TLR4 (Toll Like Receptor 4)
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IMC-001
over2years
EpCAM-targeted CAR-T cell therapy in patients with advanced colorectal and gastric cancers (ESMO 2022)
IMC001 shows a favorable safety profile and reasonable anti-tumor activities at the initial dosage level in patients with refractory EpCAM+ cancers of digestive system. Updated data from open cohorts will be presented.
Clinical • CAR T-Cell Therapy
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EPCAM (Epithelial cell adhesion molecule)
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EPCAM expression
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IMC-001 • IMC001
4years
Anti-tumor effects of NK cells and anti-PD-L1 antibody with antibody-dependent cellular cytotoxicity in PD-L1-positive cancer cell lines. (PubMed, J Immunother Cancer)
These results suggest that NK cells induce an ADCC response in combination with anti-PD-L1 mAbs, which helps promote ADCC antitumor activity against PD-L1-positive tumors. This study provides support for NK cell immunotherapy against high PD-L1-expressing tumors in combination with ADCC through anti-PD-L1 mAbs.
Preclinical • Journal • PD(L)-1 Biomarker
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PD-1 (Programmed cell death 1) • FCGR3A (Fc Fragment Of IgG Receptor IIIa)
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PD-L1 expression • PD-L1 overexpression • FCGR3A V158F
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Tecentriq (atezolizumab) • IMC-001
over4years
[VIRTUAL] Preliminary results of a phase II study of neoadjuvant immune checkpoint inhibitor IMC-001 (anti-PD-L1 monoclonal antibody) in patients with resectable gastrointestinal cancers (NeoChance Study). (ASCO 2020)
"Neoadjuvant IMC-001 seems to be well tolerated and have preliminary immune modulating activity in resectable GC, EC, and HCC pts. The study is ongoing and the updated clinical and immunologic results will be presented. Research Funding: ImmuneOncia Therapeutics, Inc., Asan Institute for Life Sciences, Asan Medical Center"
Checkpoint inhibition • P2 data • Clinical
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PD-L1 (Programmed death ligand 1)
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VENTANA PD-L1 (SP263) Assay
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IMC-001