Contact us to learn more about

our Premium Content: News alerts, weekly reports and conference planners

BIOMARKER:

ROS1 fusion + TP53 mutation

Contact us to learn more about our Premium Content:

News alerts, weekly reports and conference planners

Entrez ID:

Related biomarkers:

‹

TP53 mutation (312)

TP53 wild-type (46)

ROS1 rearrangement (15)

EGFR mutation + TP53 mutation (11)

ROS1 G2032R (8)

BRCA1 2110_2111delAA + BRCA1 4071_4096 +14del40 + TP53 R342P + NOTCH2 Q1310H (7)

ROS1 mutation (7)

ROS1 wild-type (7)

TP53 mutation + KRAS mutation (6)

ROS1 L2086F (5)

ALK rearrangement + TP53 mutation (4)

KRAS G12C + TP53 mutation (3)

ROS1 D2033N (3)

ROS1 F2004C (3)

BRCA1 mutation + TP53 mutation (2)

BRCA2 mutation + TP53 mutation (2)

CDKN2A mutation + TP53 mutation (2)

EGFR L858R + TP53 mutation (2)

EGFR mutation + TP53 mutation + ARID1A mutation (2)

EGFR mutation + TP53 mutation + BRCA1 mutation (2)

EGFR mutation + TP53 mutation + NF1 mutation (2)

EGFR mutation + TP53 mutation + PTEN mutation (2)

EGFR mutation + TP53 mutation + RB1 mutation (2)

KRAS mutation + TP53 wild-type (2)

STK11 mutation + TP53 mutation (2)

TP53 T175H + PIK3CA H1047R (2)

TP53 mutation + PIK3CA mutation + CD74 mutation (2)

CD74-ROS1 rearrangement (2)

ROS1 G2032R + ROS1 L2086F (2)

ROS1 S1986F + ROS1 G2032R + ROS1 L2086F (2)

AHNAK2 mutation + TP53 mutation (1)

ALK rearrangement + ALK L1196M + TP53 mutation (1)

ALK rearrangement + ALK R1275Q + TP53 mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

ALK rearrangement + TP53 wild-type (1)

ATRX mutation + TP53 mutation + PTEN mutation (1)

BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)

BRAF N486-P490del + TP53 V157G (1)

BRAF mutation + TP53 mutation (1)

BRCA1 mutation + TP53 R248Q (1)

BRCA2 Y1655* + TP53 mutation (1)

BRCA2 mutation + TP53 D816Y (1)

CXCR4 S338X + TP53 R196X (1)

DSPP mutation + TP53 mutation (1)

EGFR G719X + TP53 mutation (1)

EGFR L718V + TP53 V727M + EGFR L858R (1)

EGFR L858R + TP53 R273C + HER-2 S442L (1)

EGFR L858R + TP53 wild-type (1)

EGFR L861Q + TP53 mutation (1)

EGFR L861Q + TP53 mutation + RB1 mutation (1)

EGFR S768I + TP53 mutation (1)

EGFR T790M + TP53 R237C (1)

EGFR exon 19 deletion + TP53 exon 8 mutation (1)

EGFR exon 19 deletion + TP53 mutation (1)

EGFR exon 20 insertion + TP53 G244A + SPTA1 mutation (1)

EGFR mutation + BRAF mutation + TP53 mutation (1)

EGFR mutation + TP53 exon 6 mutation (1)

EGFR mutation + TP53 exon 7 mutation (1)

EGFR T790M + TP53 mutation (1)

HER-2 mutation + TP53 wild-type (1)

IDH1 mutation + TP53 mutation (1)

IDH2 mutation + TP53 mutation (1)

KMT2C mutation + TP53 mutation (1)

KRAS G12V + TP53 mutation + APC mutation (1)

KRAS mutation + STK11 mutation + TP53 mutation (1)

MET exon 14 mutation + TP53 mutation (1)

NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)

PTEN mutation + TP53 mutation (1)

RB1 mutation + TP53 mutation (1)

TERT mutation + TP53 mutation (1)

TP53 -181_-179delAAA (1)

TP53 G245S + ALK rearrangement (1)

TP53 R209fs* (1)

TP53 R333Vfs*12 (1)

TP53 exon 4 mutation (1)

TP53 exon 5 mutation (1)

TP53 exon 8 mutation (1)

TP53 mutation + ARID1A mutation (1)

TP53 mutation + ATM mutation (1)

TP53 mutation + BCL2 rearrangement (1)

TP53 mutation + CARD11 mutation + SMARCA4 mutation (1)

TP53 mutation + FGFR2 rearrangement (1)

TP53 mutation + IKZF1 mutation (1)

TP53 mutation + IKZF3 mutation (1)

TP53 mutation + MDM2 mutation (1)

TP53 mutation + NOTCH4 mutation (1)

TP53 mutation + NTRK3 mutation (1)

TP53 mutation + TSC2 mutation (1)

TP53 mutation + TTN mutation (1)

TP53 mutation + ZFHX3 mutation (1)

TP53 wild-type + LRP1B wild-type (1)

CD74-ROS1 rearrangement + ROS1 F2004V + ROS1 L2086F (1)

EGFR wild-type + ALK wild-type + ROS1 wild-type (1)

MAN1A1-ROS1 rearrangement (1)

ROS1 G2032K (1)

ROS1 L2155S (1)

ROS1 S1986F (1)

ROS1 S1986Y + ROS1 S1986F (1)

ROS1 rearrangement + BRAF V600E (1)

TFG-ROS1 rearrangement (1)

ALK mutation + TP53 mutation (0)

KRAS mutation + TP53 mutation (0)

NOTCH S2435S + TP53 G245A + TP53 P190T + TP53 FBXW7 + TP53 G477S (0)

TP53 Q16fs*28 (0)

TP53 exon 6 mutation (0)

TP53 exon 7 mutation (0)

ROS rearrangement + MET D1246N (0)

ROS1 S1986Y (0)

TP53 mutation (312)

TP53 wild-type (46)

ROS1 rearrangement (15)

EGFR mutation + TP53 mutation (11)

ROS1 G2032R (8)

BRCA1 2110_2111delAA + BRCA1 4071_4096 +14del40 + TP53 R342P + NOTCH2 Q1310H (7)

ROS1 mutation (7)

ROS1 wild-type (7)

TP53 mutation + KRAS mutation (6)

ROS1 L2086F (5)

ALK rearrangement + TP53 mutation (4)

KRAS G12C + TP53 mutation (3)

ROS1 D2033N (3)

ROS1 F2004C (3)

BRCA1 mutation + TP53 mutation (2)

BRCA2 mutation + TP53 mutation (2)

CDKN2A mutation + TP53 mutation (2)

EGFR L858R + TP53 mutation (2)

EGFR mutation + TP53 mutation + ARID1A mutation (2)

EGFR mutation + TP53 mutation + BRCA1 mutation (2)

EGFR mutation + TP53 mutation + NF1 mutation (2)

EGFR mutation + TP53 mutation + PTEN mutation (2)

EGFR mutation + TP53 mutation + RB1 mutation (2)

KRAS mutation + TP53 wild-type (2)

STK11 mutation + TP53 mutation (2)

TP53 T175H + PIK3CA H1047R (2)

TP53 mutation + PIK3CA mutation + CD74 mutation (2)

CD74-ROS1 rearrangement (2)

ROS1 G2032R + ROS1 L2086F (2)

ROS1 S1986F + ROS1 G2032R + ROS1 L2086F (2)

AHNAK2 mutation + TP53 mutation (1)

ALK rearrangement + ALK L1196M + TP53 mutation (1)

ALK rearrangement + ALK R1275Q + TP53 mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

ALK rearrangement + TP53 wild-type (1)

ATRX mutation + TP53 mutation + PTEN mutation (1)

BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)

BRAF N486-P490del + TP53 V157G (1)

BRAF mutation + TP53 mutation (1)

BRCA1 mutation + TP53 R248Q (1)

BRCA2 Y1655* + TP53 mutation (1)

BRCA2 mutation + TP53 D816Y (1)

CXCR4 S338X + TP53 R196X (1)

DSPP mutation + TP53 mutation (1)

EGFR G719X + TP53 mutation (1)

EGFR L718V + TP53 V727M + EGFR L858R (1)

EGFR L858R + TP53 R273C + HER-2 S442L (1)

EGFR L858R + TP53 wild-type (1)

EGFR L861Q + TP53 mutation (1)

EGFR L861Q + TP53 mutation + RB1 mutation (1)

EGFR S768I + TP53 mutation (1)

EGFR T790M + TP53 R237C (1)

EGFR exon 19 deletion + TP53 exon 8 mutation (1)

EGFR exon 19 deletion + TP53 mutation (1)

EGFR exon 20 insertion + TP53 G244A + SPTA1 mutation (1)

EGFR mutation + BRAF mutation + TP53 mutation (1)

EGFR mutation + TP53 exon 6 mutation (1)

EGFR mutation + TP53 exon 7 mutation (1)

EGFR T790M + TP53 mutation (1)

HER-2 mutation + TP53 wild-type (1)

IDH1 mutation + TP53 mutation (1)

IDH2 mutation + TP53 mutation (1)

KMT2C mutation + TP53 mutation (1)

KRAS G12V + TP53 mutation + APC mutation (1)

KRAS mutation + STK11 mutation + TP53 mutation (1)

MET exon 14 mutation + TP53 mutation (1)

NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)

PTEN mutation + TP53 mutation (1)

RB1 mutation + TP53 mutation (1)

TERT mutation + TP53 mutation (1)

TP53 -181_-179delAAA (1)

TP53 G245S + ALK rearrangement (1)

TP53 R209fs* (1)

TP53 R333Vfs*12 (1)

TP53 exon 4 mutation (1)

TP53 exon 5 mutation (1)

TP53 exon 8 mutation (1)

TP53 mutation + ARID1A mutation (1)

TP53 mutation + ATM mutation (1)

TP53 mutation + BCL2 rearrangement (1)

TP53 mutation + CARD11 mutation + SMARCA4 mutation (1)

TP53 mutation + FGFR2 rearrangement (1)

TP53 mutation + IKZF1 mutation (1)

TP53 mutation + IKZF3 mutation (1)

TP53 mutation + MDM2 mutation (1)

TP53 mutation + NOTCH4 mutation (1)

TP53 mutation + NTRK3 mutation (1)

TP53 mutation + TSC2 mutation (1)

TP53 mutation + TTN mutation (1)

TP53 mutation + ZFHX3 mutation (1)

TP53 wild-type + LRP1B wild-type (1)

CD74-ROS1 rearrangement + ROS1 F2004V + ROS1 L2086F (1)

EGFR wild-type + ALK wild-type + ROS1 wild-type (1)

MAN1A1-ROS1 rearrangement (1)

ROS1 G2032K (1)

ROS1 L2155S (1)

ROS1 S1986F (1)

ROS1 S1986Y + ROS1 S1986F (1)

ROS1 rearrangement + BRAF V600E (1)

TFG-ROS1 rearrangement (1)

ALK mutation + TP53 mutation (0)

KRAS mutation + TP53 mutation (0)

NOTCH S2435S + TP53 G245A + TP53 P190T + TP53 FBXW7 + TP53 G477S (0)

TP53 Q16fs*28 (0)

TP53 exon 6 mutation (0)

TP53 exon 7 mutation (0)

ROS rearrangement + MET D1246N (0)

ROS1 S1986Y (0)

›

over1year

Large-scale comparative analysis of clinico-genomic characteristics, treatment outcomes and resistant mechanisms of ALK/ROS1/RET-rearranged non-small cell lung cancer (NSCLC) in a nationwide genomic screening project (LC-SCRUM-Asia/TRY). (ASCO 2023)

TP53 mutation was associated with shorter OS in all three fusions (mOS [TP53 mt+/mt-] ALK; 35.7 vs. 108.8, p < 0.01, ROS1; 26.4 vs. 47.4, p = 0.06, RET; 28.9 vs. 76.1 months, p = 0.05), shorter PFS with first line alectinib in ALK (mPFS [TP53 mt+/mt-] 11.0 vs. 38.4 months, hazard ratio [HR] 2.5 [95% CI, 1.5-4.2], p < 0.01) and shorter PFS with initial crizotinib in ROS1 (mPFS [TP53 mt+/mt-] 5.8 vs. 25.2 months, HR 2.6 [95% CI, 1.3-4.8], p < 0.01). There was no significant difference in PFS with first-line platinum plus pemetrexed among fusions (mPFS 12.6 vs. 10.7 vs. 9.2 months) and PFS with initial immune checkpoint inhibitors among fusions (mPFS 3.9 vs. 5.1 vs. 3.0 months)... Pts with ALK/ROS1/RET-rearranged NSCLC shared similar characteristics, but the occurrence of concomitant mutations was lower in ALK than in ROS1 and RET. TP53 mutation was associated with worse prognosis in pts with ALK/ROS1/RET-rearranged NSCLC. Among those received TKI, pts with ALK-rearranged NSCLC had better prognosis than those with ROS1 and RET-rearranged NSCLC.

over 1 year ago

Clinical • IO biomarker

|

ALK (Anaplastic lymphoma kinase) • TP53 (Tumor protein P53) • RET (Ret Proto-Oncogene) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • NOTCH1 (Notch 1) • TET2 (Tet Methylcytosine Dioxygenase 2)

|

TP53 mutation • RET fusion • ALK rearrangement • ALK fusion • NOTCH1 mutation • ALK mutation • RET mutation • TET2 mutation • ROS1 fusion • ALK fusion + TP53 mutation • ROS1 fusion + TP53 mutation

|

Xalkori (crizotinib) • Alecensa (alectinib) • pemetrexed