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    BIOMARKER:

    PTEN expression

    i
    Other names: PTEN, Phosphatase and tensin homolog, Mutated In Multiple Advanced Cancers 1, Phosphatase And Tensin Homolog, Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, MMAC1, TEP1, MMAC1 Phosphatase And Tensin Homolog Deleted On Chromosome 10, Mitochondrial Phosphatase And Tensin Protein Alpha, Phosphatase And Tensin-Like Protein, Protein Tyrosine Phosphatase, Mitochondrial PTENalpha, PTENbeta, PTEN1, CWS1, GLM2, MHAM
    Entrez ID:
    5728
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    11ms
    Disruption of lipid raft reverses drug resistance in colorectal cancer cells through the phosphatase and tensin homolog/phosphoinositide 3-kinase/protein kinase B pathway and P-glycoprotein. (PubMed, Neoplasma)
    In addition, we also found that P-gp activity inhibition resulted in increased adriamycin accumulation and reversal of resistance, and flotillin knockdown was accompanied by a downregulation of P-gp expression in CRC cells. In conclusion, our study demonstrated that flotillin knockdown could reverse drug resistance in CRC cells by downregulating the PTEN/PI3K/AKT pathway and P-gp.
    Journal
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    PTEN (Phosphatase and tensin homolog)
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    PTEN expression
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    doxorubicin hydrochloride
    11ms
    Apigenin enhancing oxidative resistance and proteostasis to extend lifespan via PTEN-mediated AKT signalling pathway. (PubMed, Biochim Biophys Acta Mol Basis Dis)
    In a high-sucrose diet (HSD) model, Apigenin treatment extended lifespan, reduced hemolymph glucose levels, enhanced Pten expression, suppressed AKT phosphorylation, and modulated the phosphorylation status of S6K and expression of DmFoxo. These results demonstrate that apigenin could serve as a longevity research object and potential therapeutic drug for promoting health and longevity through its antioxidant and proteostatic properties.
    Journal
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    PTEN (Phosphatase and tensin homolog) • AKT1 (V-akt murine thymoma viral oncogene homolog 1)
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    PTEN expression
    11ms
    The Suppression of Signal Transducer and Activator of Transcription-3 in A549 human Lung Carcinoma Cells Induced by Marine Sponge Callyspongia aerizusa. (PubMed, J Exp Pharmacol)
    In conclusion, the ergosteroids present in marine sponge C. aerizusa extract signified a remarkable reduction in malignancy, migration, and invasion capabilities in A549 lung carcinoma cells. These results suggested their promising candidacy for future anti-angiogenesis in anticancer therapy.
    Journal
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    PTEN (Phosphatase and tensin homolog) • IL6 (Interleukin 6) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • STAT3 (Signal Transducer And Activator Of Transcription 3)
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    PTEN expression • HIF1A expression • IL6 expression
    11ms
    Complex immunohistochemical and molecular study on 5 cases of ovarian juvenile granulosa cell tumors reveals a consistent alteration in the PI3K/AKT/mTOR signaling pathway. (PubMed, Diagn Pathol)
    The results of our study further support the hypothesis that the pathogenesis of JGCT may be driven by activation of the PIK3/AKT/mTOR pathway. These findings could potentially have future therapeutic implications, as treatment strategies targeting the PTEN/mTOR pathways are currently under investigation.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • TP53 (Tumor protein P53) • AR (Androgen receptor) • ARID1A (AT-rich interaction domain 1A) • TERT (Telomerase Reverse Transcriptase) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • WT1 (WT1 Transcription Factor) • NKX2-1 (NK2 Homeobox 1) • CA9 (Carbonic anhydrase 9) • MUC4 (Mucin 4, Cell Surface Associated) • SALL4 (Spalt Like Transcription Factor 4) • CD99 (CD99 Molecule) • EP400 (E1A Binding Protein P400) • GATA3 (GATA binding protein 3) • NAPSA (Napsin A Aspartic Peptidase) • FOXL2 (Forkhead Box L2)
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    PD-L1 expression • HER-2 negative • HER-2 expression • PTEN expression • AKT1 mutation • TERT mutation • TP53 expression • MUC4 expression • CA9 expression
    11ms
    Comparison of cytogenetic and molecular features observed in endometrial cancers: known clinic and difficulties in treatment. (PubMed, Cir Cir)
    The up-regulation of tumor suppressor genes in our study shows that not only these genes are involved but also different pathways and factors play a role in tumorigenesis. Furthermore, an increased number of NCCAs shows an essential role in the development of ECs.
    Journal
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    TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PTEN (Phosphatase and tensin homolog) • ARID1A (AT-rich interaction domain 1A) • POLE (DNA Polymerase Epsilon)
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    PTEN expression • TP53 expression
    11ms
    Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial) (clinicaltrials.gov)
    P2, N=18, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Oct 2024 --> Oct 2025
    Trial completion date
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    PTEN (Phosphatase and tensin homolog) • TSC2 (TSC complex subunit 2) • TSC1 (TSC complex subunit 1)
    |
    PTEN expression • TSC1 mutation • TSC2 mutation
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    samotolisib (LY3023414)
    11ms
    Potential Contribution of Epithelial Growth Factor Receptor to PI3K/AKT Pathway Dysregulation in Canine Soft Tissue Sarcoma. (PubMed, In Vivo)
    EGFR over-expression, rather than PTEN loss or PIK3CA mutations, may contribute to PI3K/AKT pathway dysregulation in canine STS. Further studies with larger sample sizes and additional validation techniques are necessary to confirm these findings.
    Journal
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    EGFR (Epidermal growth factor receptor) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PTEN (Phosphatase and tensin homolog)
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    EGFR mutation • PIK3CA mutation • EGFR expression • PTEN expression • EGFR positive • EGFR mutation + PIK3CA mutation • PIK3CA expression • PIK3CA overexpression
    11ms
    MiR-363-3p induces tamoxifen resistance in breast cancer cells through PTEN modulation. (PubMed, Sci Rep)
    Ultimately, miR-363-3p decreased the responsiveness of breast cancer cells to TAM by targeting and suppressing PTEN through a mechanism associated with the PI3K-Akt pathway. Therefore, these results suggest that miR-363-3p-dependent PTEN expression contributes to the mechanisms underlying breast cancer endocrine resistance.
    Journal
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    PTEN (Phosphatase and tensin homolog) • MIR363 (MicroRNA 363)
    |
    PTEN expression
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    tamoxifen
    11ms
    Tumor hypoxia evidences the differential regulation of Mdm2-p53 axis by PTEN in tumor derived vs. normal endothelial cells. (PubMed, Sci Rep)
    In conclusion, the PTEN-mediated control of pathological angiogenesis occurs by modulation of Mdm2/p53 interaction in the context of breast tumor microenvironment. PTEN emerges as a potential therapeutic target for normalizing tumor vessels in breast cancer treatment strategies.
    Journal
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    PTEN (Phosphatase and tensin homolog) • MDM2 (E3 ubiquitin protein ligase)
    |
    PTEN expression
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    Nutlin-3
    11ms
    Role of KIF20A Depletion in Inhibiting Ovarian Cancer Progression: Insights From PTEN and M2 Macrophage Polarization. (PubMed, Discov Med)
    KIF20A was found to induce M2 macrophage polarization in ovarian cancer, and KIF20A depletion regulated PTEN to increase radiosensitivity and inhibit ovarian cancer development.
    Journal
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    PTEN (Phosphatase and tensin homolog) • KIF20A (Kinesin Family Member 20A)
    |
    PTEN expression
    12ms
    miR-105-5p/PTEN Axis Modulates the Immune Response and Epithelial-Mesenchymal Transition of Colon Cancer via NF-κB Activation. (PubMed, J Biochem Mol Toxicol)
    It also distinctly deactivated the NF-κB pathway. To sum up, these data indicated that miR-105-5p depletion might impede EMT, yet enhance the immune response in CC by elevating PTEN expressions via deactivation of the NF-κB pathway.
    Journal
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    PTEN (Phosphatase and tensin homolog) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta) • NFKBIA (NFKB Inhibitor Alpha 2) • MIR105 (MicroRNA 105) • RELA (RELA Proto-Oncogene)
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    PTEN expression • RELA expression
    12ms
    Metformin protects prepubertal mice ovarian reserve against cyclophosphamide via regulation of the PI3K/Akt/mTOR signaling pathway and Yap-1. (PubMed, J Ovarian Res)
    Our results advocate for the potential of metformin as a viable therapeutic option for preserving ovarian function in cyclophosphamide-treated adolescent girls, given its favorable side effect profile and ability to improve cyclophosphamide-induced ovarian damage.
    Preclinical • Journal • IO biomarker
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    PTEN (Phosphatase and tensin homolog) • BCL2 (B-cell CLL/lymphoma 2) • RAD51 (RAD51 Homolog A) • YAP1 (Yes associated protein 1) • BAX (BCL2-associated X protein)
    |
    PTEN expression • TP53 expression • BAX expression
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    cyclophosphamide • metformin