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BIOMARKER:

PTEN loss

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Other names: PTEN, Phosphatase and tensin homolog, Mutated In Multiple Advanced Cancers 1, Phosphatase And Tensin Homolog, Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, MMAC1, TEP1, MMAC1 Phosphatase And Tensin Homolog Deleted On Chromosome 10, Mitochondrial Phosphatase And Tensin Protein Alpha, Phosphatase And Tensin-Like Protein, Protein Tyrosine Phosphatase, Mitochondrial PTENalpha, PTENbeta, PTEN1, CWS1, GLM2, MHAM
Entrez ID:
Related biomarkers:
PTEN loss
Prostate Cancer
GDC-0068 + AST-2970 + prednisolone
Sensitive: B - Late Trials
PTEN loss
Breast Cancer
bevacizumab + temsirolimus
Sensitive: C3 – Early Trials
PTEN loss
Melanoma
vemurafenib
Sensitive: C3 – Early Trials
PTEN loss
CRC
bevacizumab + nanoparticle albumin-bound rapamycin
Sensitive: C3 – Early Trials
PTEN loss
Triple Negative Breast Cancer
AZD8186
Sensitive: D – Preclinical
PTEN loss
Prostate Cancer
apalutamide + AZD4635
Sensitive: D – Preclinical
PTEN loss
Prostate Cancer
AZD4635
Sensitive: D – Preclinical
PTEN loss
NSCLC
GDC-0941
Sensitive: D – Preclinical
PTEN loss
Melanoma
GSK2636771 + ENUM004
Sensitive: D – Preclinical
PTEN loss
LUAD
selumetinib + MK-2206
Sensitive: D – Preclinical
PTEN loss
NSCLC
erlotinib
Resistant: D – Preclinical
PTEN loss
Prostate Cancer
enzalutamide + AZD5363
Sensitive: D – Preclinical