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    DRUG:

    AVA6000

    i
    Other names: AVA6000, FAP-activated doxorubicin prodrug
    Associations

    News

    Trials
    Company:
    Avacta
    Drug class:
    Topoisomerase II inhibitor
    Related drugs:
    Associations

    News

    Trials
    over2years
    AVA6000, a novel Precision medicine, targeted to the tumor microenvironment via Fibroblast Activation Protein (FAP) mediated cleavage (AACR 2022)
    In a PDX model of osteosarcoma, AVA6000 significantly decreased tumor volume while doxorubicin had no significant effect. The efficacy and tolerability profile of AVA6000 strongly support its clinical development, and a Phase I trial in patients with locally advanced or metastatic selected solid tumours in underway.
    FAP (Fibroblast activation protein, alpha)
    |
    AVA6000