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DRUG:

nab-paclitaxel/rituximab nanoparticle (AR160)

i
Other names: AR160
Company:
Mayo Clinic, Sorrento
Drug class:
Bcl2 inhibitor, CD20 inhibitor, Tubulin inhibitor
Related drugs:
1year
A First in Human Phase I Trial (LS1681) of Abraxane/Rituximab 160 Nm Nanoparticle (AR160) in Relapsed Refractory B-Cell Lymphomas Including Transformed Follicular Lymphoma: A Final Report (ASH 2023)
AR160 therapy is a novel drug delivery system incorporating significantly lower doses of paclitaxel and rituximab that is safe and demonstrates promising clinical activity in patients with low-grade and high-grade previously treated B-cell lymphomas. This principle of treatment is applicable to other disorders. Further clinical testing is warranted in these patient populations.
P1 data
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BCL2 (B-cell CLL/lymphoma 2) • CD20 (Membrane Spanning 4-Domains A1)
|
CD20 expression • MYC rearrangement • BCL2 rearrangement
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Rituxan (rituximab) • albumin-bound paclitaxel • nab-paclitaxel/rituximab nanoparticle (AR160)
over1year
Nab-paclitaxel/Rituximab-coated Nanoparticle AR160 in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma, LS1681 Trial (clinicaltrials.gov)
P1, N=9, Completed, Mayo Clinic | Suspended --> Completed | N=18 --> 9 | Trial completion date: Apr 2024 --> May 2023 | Trial primary completion date: Oct 2023 --> May 2023
Trial completion • Enrollment change • Trial completion date • Trial primary completion date
|
CD20 (Membrane Spanning 4-Domains A1)
|
Rituxan (rituximab) • albumin-bound paclitaxel • nab-paclitaxel/rituximab nanoparticle (AR160)
over1year
Trial primary completion date
|
CD20 (Membrane Spanning 4-Domains A1)
|
Rituxan (rituximab) • albumin-bound paclitaxel • nab-paclitaxel/rituximab nanoparticle (AR160)
almost2years
Nab-paclitaxel/Rituximab-coated Nanoparticle AR160 in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma, LS1681 Trial (clinicaltrials.gov)
P1, N=18, Suspended, Mayo Clinic | Trial completion date: Jun 2023 --> Apr 2024 | Recruiting --> Suspended
Trial completion date • Trial suspension
|
CD20 (Membrane Spanning 4-Domains A1)
|
Rituxan (rituximab) • albumin-bound paclitaxel • nab-paclitaxel/rituximab nanoparticle (AR160)
over2years
Nab-paclitaxel/Rituximab-coated Nanoparticle AR160 in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (clinicaltrials.gov)
P1, N=18, Recruiting, Mayo Clinic | Trial completion date: Jun 2022 --> Jun 2023 | Trial primary completion date: Jun 2022 --> Jun 2023
Trial completion date • Trial primary completion date
|
CD20 (Membrane Spanning 4-Domains A1)
|
Rituxan (rituximab) • albumin-bound paclitaxel • nab-paclitaxel/rituximab nanoparticle (AR160)