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DRUG:

lisaftoclax (APG-2575)

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Company:

Ascentage Pharma

Drug class:

Bcl2 inhibitor

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Chr amplification(1)(q21)	Multiple Myeloma	Chr amplification(1)(q21)	Multiple Myeloma	lenalidomide + APG-2575 Sensitive: D – Preclinical lenalidomide + APG-2575 Sensitive : D	lenalidomide + APG-2575 Sensitive: D – Preclinical lenalidomide + APG-2575 Sensitive : D
Chr t(11;14)	Multiple Myeloma	Chr t(11;14)	Multiple Myeloma	APG-2575 Sensitive: D – Preclinical APG-2575 Sensitive : D	APG-2575 Sensitive: D – Preclinical APG-2575 Sensitive : D
BCL2 overexpression + MCL1 overexpression	Diffuse Large B Cell Lymphoma	BCL2 overexpression + MCL1 overexpression	Diffuse Large B Cell Lymphoma	ibrutinib + APG-2575 Sensitive: D – Preclinical ibrutinib + APG-2575 Sensitive : D	ibrutinib + APG-2575 Sensitive: D – Preclinical ibrutinib + APG-2575 Sensitive : D
BCL2 overexpression + MCL1 expression	Diffuse Large B Cell Lymphoma	BCL2 overexpression + MCL1 expression	Diffuse Large B Cell Lymphoma	APG-115 + APG-2575 Sensitive: D – Preclinical APG-115 + APG-2575 Sensitive : D	APG-115 + APG-2575 Sensitive: D – Preclinical APG-115 + APG-2575 Sensitive : D
BCL2 overexpression	Diffuse Large B Cell Lymphoma	BCL2 overexpression	Diffuse Large B Cell Lymphoma	APG-2575 Sensitive: D – Preclinical APG-2575 Sensitive : D	APG-2575 Sensitive: D – Preclinical APG-2575 Sensitive : D
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FLT3-ITD mutation	Acute Myelogenous Leukemia	FLT3-ITD mutation	Acute Myelogenous Leukemia	olverembatinib + APG-2575 Sensitive: D – Preclinical olverembatinib + APG-2575 Sensitive : D	olverembatinib + APG-2575 Sensitive: D – Preclinical olverembatinib + APG-2575 Sensitive : D