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DRUG:

pelcitoclax (APG-1252)

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News alerts, weekly reports and conference planners

Company:

Ascentage Pharma

Drug class:

Bcl2 inhibitor, Bcl-xL inhibitor

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Bcl-2 Family Inhibitors (0)

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paclitaxel liposomal (0)

liposomal paclitaxel (0)

paclitaxel nanoformulation (0)

paclitaxel-hyaluronic acid conjugate (0)

paclitaxel poliglumex (0)

bisphosphonate bound paclitaxel (0)

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EGFR T790M	Non Small Cell Lung Cancer	EGFR T790M	Non Small Cell Lung Cancer	osimertinib + APG-1252 Sensitive: C3 – Early Trials osimertinib + APG-1252 Sensitive : C3	osimertinib + APG-1252 Sensitive: C3 – Early Trials osimertinib + APG-1252 Sensitive : C3
EGFR mutation	Non Small Cell Lung Cancer	EGFR mutation	Non Small Cell Lung Cancer	osimertinib + APG-1252 Sensitive: C3 – Early Trials osimertinib + APG-1252 Sensitive : C3	osimertinib + APG-1252 Sensitive: C3 – Early Trials osimertinib + APG-1252 Sensitive : C3
BCL2L1 overexpression	Non Small Cell Lung Cancer	BCL2L1 overexpression	Non Small Cell Lung Cancer	osimertinib + APG-1252 Sensitive: C3 – Early Trials osimertinib + APG-1252 Sensitive : C3	osimertinib + APG-1252 Sensitive: C3 – Early Trials osimertinib + APG-1252 Sensitive : C3
TP53 mutation	Non Small Cell Lung Cancer	TP53 mutation	Non Small Cell Lung Cancer	osimertinib + APG-1252 Sensitive: C3 – Early Trials osimertinib + APG-1252 Sensitive : C3	osimertinib + APG-1252 Sensitive: C3 – Early Trials osimertinib + APG-1252 Sensitive : C3
EGFR T790M	Non Small Cell Lung Cancer	EGFR T790M	Non Small Cell Lung Cancer	APG-1252 Sensitive: D – Preclinical APG-1252 Sensitive : D	APG-1252 Sensitive: D – Preclinical APG-1252 Sensitive : D
EGFR C797S	Non Small Cell Lung Cancer	EGFR C797S	Non Small Cell Lung Cancer	APG-1252 Sensitive: D – Preclinical APG-1252 Sensitive : D	APG-1252 Sensitive: D – Preclinical APG-1252 Sensitive : D
HER-2 positive	Gastric Cancer	HER-2 positive	Gastric Cancer	lapatinib + APG-1252 Sensitive: D – Preclinical lapatinib + APG-1252 Sensitive : D	lapatinib + APG-1252 Sensitive: D – Preclinical lapatinib + APG-1252 Sensitive : D
BCL2L1 overexpression	Gastric Cancer	BCL2L1 overexpression	Gastric Cancer	APG-1252 Sensitive: D – Preclinical APG-1252 Sensitive : D	APG-1252 Sensitive: D – Preclinical APG-1252 Sensitive : D