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DRUG:

MT-6402

i
Other names: MT-6402, MT 6402, MT6402
Company:
Molecular Templates
Drug class:
PD-L1 inhibitor
Related drugs:
10d
MT-6402-001: Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1 (clinicaltrials.gov)
P1, N=64, Terminated, Molecular Templates, Inc. | N=138 --> 64 | Active, not recruiting --> Terminated; Terminated by Sponsor
Enrollment change • Trial termination • IO biomarker • Metastases
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PD-L1 (Programmed death ligand 1)
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PD-L1 expression
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MT-6402
24d
MT-6402-001: Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1 (clinicaltrials.gov)
P1, N=138, Active, not recruiting, Molecular Templates, Inc. | Recruiting --> Active, not recruiting | Trial completion date: May 2026 --> Oct 2024 | Trial primary completion date: Apr 2025 --> Oct 2024
Enrollment closed • Trial completion date • Trial primary completion date • IO biomarker • Metastases
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PD-L1 (Programmed death ligand 1)
|
PD-L1 expression
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MT-6402
over1year
Engineered Toxin Bodies (ETBs): Clinical stage immunotoxins with a safer and differentiated profile (AACR 2023)
Three ETBs (MT-0169, MT-5111, and MT-6402) are currently in clinical studies across different targets (CD38, HER2, PD-L1) and across hematologic malignancies, solid tumor, and immuno-oncology indications. ETBs can also deliver additional payloads to drive unique biology like the alteration of tumor immunophenotype. Here we describe three active clinical stage programs with encouraging safety and efficacy data that represent a transformation of the immunotoxin landscape into a more viable therapeutic approach to target validated as well as typically intractable clinical cancer targets.
Clinical
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HER-2 (Human epidermal growth factor receptor 2)
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MT-5111 • MT-6402 • MT-0169
over2years
Altering tumor immunophenotypes with PD-L1 engineered toxin bodies (AACR 2022)
These cytokines overlap with cytokine signatures observed after dosing MT-6402 in HLA:A*02 patients. Preclinical assessment of the safety profile of candidates is ongoing and further development is slated for 2021.
PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1)
|
PD-L1 expression
|
MT-6402
over3years
[VIRTUAL] First - in - Human, Dose Escalation and Expansion Study of MT - 6402 in Patients With PD - L1 Expressing Advanced Solid Tumors (IASLC-WCLC 2021)
Introduction MT-6402 is a de-immunized engineered toxin body (ETB) targeting PD-L1 for solid tumors that carries a Shiga-like Toxin-A (SLT-A) payload with the addition of cytomegalovirus (CMV) antigen seeding technology (AST)...In Part A, the starting dose will be 16 µg/kg based upon the highest non-severely toxic dose in non-human primates; in Part B, the starting dose will be the MTD determined in Part A. Treatment will continue until disease progression, unacceptable toxicity, death, withdrawal of consent, or another reason. Enrollment is estimated to begin at several US centers in the first half of 2021.
Clinical
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PD-L1 expression
|
VENTANA PD-L1 (SP263) Assay
|
MT-6402
over3years
Enrollment open • Clinical
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PD-L1 (Programmed death ligand 1)
|
PD-L1 expression
|
VENTANA PD-L1 (SP263) Assay
|
MT-6402
over3years
Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1 (clinicaltrials.gov)
P1; N=138; Not yet recruiting; Sponsor:Molecular Templates, Inc.
New P1 trial • Clinical
|
PD-L1 (Programmed death ligand 1)
|
PD-L1 expression
|
VENTANA PD-L1 (SP263) Assay
|
MT-6402
over4years
[VIRTUAL] In vivo efficacy of a PD-L1 targeted, antigen seeding engineered toxin body (AACR-II 2020)
MT-6402 delivers a powerful and unique dual mechanism of action. The combination of a PD-L1 specific direct cell kill and redirection of a robust effector T cell response to the tumor has potential benefit in solid tumor indications, including in the relapsed setting, when disease has progressed after checkpoint and/or other therapies.
Preclinical • PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1)
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PD-L1 expression • PD-L1 underexpression • PD-L1 negative
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MT-6402