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DRUG:

betifisolimab (MSB2311)

i
Other names: MSB2311, MSB-2311, MSB 2311
Associations
Trials
Company:
Transcenta
Drug class:
PD-L1 inhibitor
Related drugs:
Associations
Trials
11ms
MSB2311-CSP-002t: A Study of MSB2311 in Advanced Solid Tumors (clinicaltrials.gov)
P1, N=42, Completed, Suzhou Transcenta Therapeutics Co., Ltd. | Recruiting --> Completed | N=60 --> 42
Trial completion • Enrollment change • Metastases
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betifisolimab (MSB2311)
11ms
A Phase I Study of MSB2311 in Advanced Solid Tumors (clinicaltrials.gov)
P1, N=42, Completed, Suzhou Transcenta Therapeutics Co., Ltd. | N=19 --> 42
Enrollment change • Metastases
|
betifisolimab (MSB2311)
over1year
Phase I study of MSB2311, a novel pH-dependent anti-PD-L1 monoclonal antibody, treating patients with advanced solid tumors and lymphoma. (PubMed, Cancer Immunol Immunother)
One partial response was also observed among 6 patients with lymphoma. MSB2311 demonstrated a manageable safety profile and promising antitumor activity in patients with advanced solid tumors and lymphomas.
P1 data • Journal • Tumor mutational burden • MSi-H Biomarker • PD(L)-1 Biomarker • IO biomarker • Metastases
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TMB (Tumor Mutational Burden) • MSI (Microsatellite instability)
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TMB-H • MSI-H/dMMR • PD-L1 overexpression
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betifisolimab (MSB2311)