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Duoenda (mitoxantrone liposomal)
i
Other names: PLM60, 2010L04017, HE071
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News alerts, weekly reports and conference planners
Company:
CSPC Pharma
Drug class:
Topoisomerase II inhibitor, DNA intercalator
Related drugs:
3d
Prospective, single-arm, multicenter clinical study of rituximab combined with cyclophosphamide, mitoxantrone liposomes, vincristine, and prednisone (R-CMOP) regimen in the treatment of previously untreated diffuse large B-cell lymphoma in patients aged 60 years or older or with underlying heart disease (ChiCTR2600117000)
P=N/A, N=72, Not yet recruiting, The First Affiliated Hospital, College of Medicine, Zhejiang University; The First Affiliated Hospital of Zhejiang University School of Medicine
New trial
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Rituxan (rituximab) • cyclophosphamide • prednisone • Marqibo (vincristine liposomal) • Duoenda (mitoxantrone liposomal) • vindesine
3d
Clinical Study on the Efficacy and Safety of Zeprumetostat, Azacitidine Combined with Lipo-MIT in Relapsed/Refractory Peripheral T-Cell Lymphoma. (ChiCTR2600116686)
P2, N=26, Not yet recruiting, The First Affiliated Hospital of Soochow University; The First Affiliated Hospital of Soochow University
New P2 trial
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azacitidine • zeprumetostat (SHR-2554) • Duoenda (mitoxantrone liposomal)
3d
A single-Arm, Open-Label Ib/II Study of Mitoxantrone Hydrochloride Liposome and Enlonstobart Combination Treatment in Patients With Relapsed or Refractory Peripheral T Cell Lymphoma(PTCL) (ChiCTR2500111610)
P1/2, N=43, Not yet recruiting, Sun Yat-sen University Cancer Center; Sun Yat-sen University Cancer Center
New P1/2 trial
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Duoenda (mitoxantrone liposomal) • Enshuxing (enlonstobart)
6d
Zeprumetostat, Azacitidine Combined With Lipo-MIT in R/R PTCL (clinicaltrials.gov)
P2, N=26, Recruiting, The First Affiliated Hospital of Soochow University
New P2 trial
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azacitidine • zeprumetostat (SHR-2554) • Duoenda (mitoxantrone liposomal)
1m
Golidocitinib Combined With Mitoxantrone Hydrochloride Liposome or Chidamide in the Treatment of Relapsed or Refractory Peripheral T-cell Lymphoma (clinicaltrials.gov)
P1/2, N=101, Recruiting, Sun Yat-sen University | Not yet recruiting --> Recruiting
Enrollment open
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Epidaza (chidamide) • golidocitinib (DZD4205) • Duoenda (mitoxantrone liposomal)
2ms
Mitoxantrone Hydrochloride Liposome and Enlonstobart Combination Treatment in Patients With Relapsed or Refractory Peripheral T Cell Lymphoma (PTCL) (clinicaltrials.gov)
P1/2, N=43, Not yet recruiting, Sun Yet-Sen University Cancer Center
New P1/2 trial
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Duoenda (mitoxantrone liposomal) • Enshuxing (enlonstobart)
2ms
Primary ALK-Negative Anaplastic Large Cell Lymphoma Mimicking Septic Arthritis in a Diabetic Patient: Diagnostic and Therapeutic Challenges. (PubMed, J Vis Exp)
A carefully staged treatment plan was employed, beginning with corticosteroids and etoposide, followed by liposomal mitoxantrone and the CD30-targeted antibody-drug conjugate brentuximab vedotin. The clinical course highlights the necessity of maintaining a high index of suspicion for lymphoma in refractory joint infections and demonstrates that individualized, stepwise therapy can achieve remission even in critically ill patients with aggressive ALCL. These findings provide valuable insights for improving the diagnosis and management of lymphoma cases that mimic infectious diseases.
Journal
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ALK (Anaplastic lymphoma kinase) • TNFRSF8 (TNF Receptor Superfamily Member 8)
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ALK negative
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etoposide IV • Adcetris (brentuximab vedotin) • Duoenda (mitoxantrone liposomal)
3ms
A prospective multicenter randomized controlled clinical study comparing the efficacy and safety of mitoxantrone hydrochloride liposomes with idarubicin in induction therapy for children with newly diagnosed acute myelocytic leukemia (ChiCTR2500111195)
P=N/A, N=220, Not yet recruiting, The First Affiliated Hospital,Sun Yat-sen University; The First Affiliated Hospital,Sun Yat-sen University
New trial
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Venclexta (venetoclax) • idarubicin hydrochloride • Duoenda (mitoxantrone liposomal)
3ms
Study on the Efficacy and Safety of Mitoxantrone Liposome-Containing Regimens in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia in the Real World (ChiCTR2500111194)
P4, N=60, Recruiting, Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology; Tongji Hospital Affiliated to Tongji Medical Colle
New P4 trial • Real-world evidence
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Venclexta (venetoclax) • azacitidine • Duoenda (mitoxantrone liposomal)
3ms
A Prospective, Multicenter, Randomized Controlled, Phase II Clinical Study of Venetoclax and Azacitidine Combined with Mitoxantrone Hydrochloride Liposome Injection Versus Intensive Chemotherapy in the Treatment of Newly Diagnosed Intermediate- to High-Risk fit AML (ChiCTR2500109764)
P4, N=198, Not yet recruiting, Tangdu Hospital, Fourth Military Medical University; Tangdu Hospital, Fourth Military Medical University
New P4 trial
|
Venclexta (venetoclax) • azacitidine • Duoenda (mitoxantrone liposomal)
3ms
A multicenter, single-arm, phase II clinical study of mitoxantrone hydrochloride liposome injection combined with azacitidine and venetoclax in the treatment of relapsed/refractory acute myeloid leukemia after standard induction therapy (ChiCTR2500109729)
P4, N=38, Not yet recruiting, The First Affiliated Hospital of Army Medical University; The First Affiliated Hospital of Army Medical University
New P4 trial
|
Venclexta (venetoclax) • azacitidine • Duoenda (mitoxantrone liposomal)
3ms
A multicenter, single-arm, phase II clinical study of mitoxantrone hydrochloride liposome injection combined with azacitidine and venetoclax in the treatment of venetoclax-exposed refractory/relapsed acute myeloid leukemia (ChiCTR2500109360)
P4, N=30, Not yet recruiting, The First Affiliated Hospital of Army Medical University; The First Affiliated Hospital of Army Medical University
New P4 trial
|
Venclexta (venetoclax) • azacitidine • Duoenda (mitoxantrone liposomal)
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