^
1d
Twelve-Month Retrospective Evaluation of Clinical Whole-Exome Sequencing (WES) Results for Indolent B Cell Lymphomas (AMP 2024)
Our NGS testing found tier 1 or 2 variants in the majority of cases, supporting its use in the clinical setting. Additionally, a subset of variants identified with the pan-Heme list likely represents mutations of clonal hematopoiesis of indeterminate potential, which could be removed with a more lymphoma-specific gene list. Given these findings, and a growing number of targets in indolent B cell lymphomas, future studies focusing on evaluation of a lymphoma-specific gene list is of interest for clinical validation and implementation.
Retrospective data • Whole exome sequencing
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KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • RB1 (RB Transcriptional Corepressor 1) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • SF3B1 (Splicing Factor 3b Subunit 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • NOTCH2 (Notch 2) • CREBBP (CREB binding protein)
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FusionPlex™ Pan-Heme panel • PanHeme assay
4d
The efficacy of Zebutinib in first-line treatment of localized salivary gland MALT lymphoma (ChiCTR2400090558)
P4, N=33, Recruiting, Shanghai Ninth Peopole's Hospital, Shanghai Jiaotong University School of Medicine; Shanghai Ninth Peopole's Hospital, Shanghai Jiaotong University Sc
New P4 trial
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Brukinsa (zanubrutinib)
8d
A case of pulmonary mucosa-associated lymphoid tissue lymphoma diagnosed by detecting t(11;18)(q21;q21) in bronchial lavage fluid. (PubMed, Respir Med Case Rep)
MALT lymphoma is often difficult to diagnose by bronchoscopy because of only mild dysplasia. However, present report on using chromosomal translocation analysis from bronchial lavage indicates that such testing may serve as a useful diagnostic adjunct in MALT lymphoma with lung involvement.
Journal
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BIRC3 (Baculoviral IAP repeat containing 3) • MALT1 (MALT1 Paracaspase)
10d
A rare case of splenic marginal zone lymphoma with MYD88 mutation transformed into diffuse large B-cell lymphoma: case report and literature review. (PubMed, Ann Hematol)
Through this case, we reviewed relevant studies, which indicated that MYD88 mutations, along with other genetic anomalies, may play a significant role in this process. In the future, it is essential to collect more of these rare cases for further research.
Review • Journal
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MYD88 (MYD88 Innate Immune Signal Transduction Adaptor)
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MYD88 mutation
10d
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases (clinicaltrials.gov)
P=N/A, N=200, Recruiting, Masonic Cancer Center, University of Minnesota | Trial completion date: Oct 2025 --> Oct 2026 | Trial primary completion date: Oct 2024 --> Oct 2025
Trial completion date • Trial primary completion date
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KMT2A (Lysine Methyltransferase 2A) • IKZF1 (IKAROS Family Zinc Finger 1)
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MLL rearrangement • MLL rearrangement
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cyclophosphamide • fludarabine IV • cyclosporin A microemulsion
13d
Endoscopic morphology of gastric MALT lymphoma correlate with API2/MALT1 fusion and predict treatment response after helicobacter pylori eradication. (PubMed, BMC Gastroenterol)
Gastric MALT lymphomas with superficial-type morphology, particularly those with defined borders resembling early gastric cancer, were associated with API2/MALT1 fusion and a lower remission rate after Hp eradication therapy. This suggests that endoscopic morphology, along with API2/MALT1 fusion status, could help predict the therapeutic response, with API2/MALT1 fusion serving as a critical indicator of treatment resistance.
Retrospective data • Journal
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BIRC3 (Baculoviral IAP repeat containing 3) • MALT1 (MALT1 Paracaspase)
14d
NCI-2021-12489: Mosunetuzumab With or Without Polatuzumab Vedotin and Obinutuzumab for the Treatment of Untreated Indolent B-Cell Non-Hodgkin Lymphoma (clinicaltrials.gov)
P2, N=42, Active, not recruiting, University of Washington | Recruiting --> Active, not recruiting | Trial completion date: Dec 2025 --> Mar 2025 | Trial primary completion date: Dec 2025 --> Mar 2025
Enrollment closed • Trial completion date • Trial primary completion date
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Gazyva (obinutuzumab) • Polivy (polatuzumab vedotin-piiq) • Lunsumio (mosunetuzumab-axgb)
14d
RCT on Intralesional Rituximab Injection Versus ISRT in Ocular Adnexal MALT Lymphoma (clinicaltrials.gov)
P=N/A, N=108, Recruiting, Zhongshan Ophthalmic Center, Sun Yat-sen University | Trial completion date: Dec 2027 --> Dec 2029 | Trial primary completion date: Dec 2027 --> Dec 2029
Trial completion date • Trial primary completion date
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Rituxan (rituximab)
15d
Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously after Helicobacter pylori eradication: A case report. (PubMed, World J Gastrointest Oncol)
Because the patient had a MALT1 translocation with trisomy 18q21, it was thought that this gastric MALT lymphoma developed independently of H. pylori infection and progressed.
Journal
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BIRC3 (Baculoviral IAP repeat containing 3) • MALT1 (MALT1 Paracaspase)
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Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone
18d
PIMENTO: FDG PET Evaluation for Marginal Zone Lymphoma and Its Prognostic Role (clinicaltrials.gov)
P=N/A, N=350, Recruiting, International Extranodal Lymphoma Study Group (IELSG) | Trial completion date: Jan 2024 --> Dec 2025 | Trial primary completion date: Jan 2024 --> Dec 2025
Trial completion date • Trial primary completion date • FDG PET
19d
Clinicopathological characteristics and genomic profiling in patients with transformed lymphoma: a monocentric retrospective study. (PubMed, Ann Med)
Whole-exome sequencing and copy-number analysis revealed that tMZL derives from the divergent evolution of an ancestral common progenitor clone (CPC). Collectively, this study provides clinicopathological characteristics of three common types of transformed lymphomas and the genetic profile of tMZL with diagnostic and therapeutic implications.
Retrospective data • Journal
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MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CD79B (CD79b Molecule) • CREBBP (CREB binding protein) • CARD11 (Caspase Recruitment Domain Family Member 11) • EP300 (E1A binding protein p300) • TNFAIP3 (TNF Alpha Induced Protein 3)
24d
Cyclin-D1 rearrangement as a secondary event in the large cell transformation of splenic marginal zone lymphoma with a TP53 deletion. (PubMed, Virchows Arch)
Sequencing of the two lymphomas demonstrated clonal relatedness of the two processes. To our knowledge, this is the first report of a splenic marginal zone lymphoma with a TP53 deletion at diagnosis, evolving into a large B-cell lymphoma with a CCND1 rearrangement.
Journal
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TP53 (Tumor protein P53) • CCND1 (Cyclin D1)
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TP53 deletion • CCND1 overexpression
28d
OSU-23307: Pirtobrutinib in Combination With Rituximab in Newly Diagnosed Marginal Zone Lymphoma (R+Pirto in Newly Diagnosed MZL) (clinicaltrials.gov)
P2, N=23, Not yet recruiting, University of Utah | Trial completion date: Dec 2025 --> Dec 2032 | Initiation date: May 2024 --> Dec 2024 | Trial primary completion date: Dec 2025 --> Dec 2031
Trial completion date • Trial initiation date • Trial primary completion date • Combination therapy
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Rituxan (rituximab) • Jaypirca (pirtobrutinib)
28d
New P2 trial
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Rituxan (rituximab) • Brukinsa (zanubrutinib)
28d
The clinical utility of plasma circulating tumor DNA in the diagnosis and disease surveillance in non-diffuse large B-cell non-Hodgkin lymphomas. (PubMed, Future Oncol)
Particularly, IGH-BCL2 and IGH-CCND1 fusions were concordant between plasma and tumor biopsies in FLs (91.1%) and MCLs (91.3%), respectively. Longitudinal data demonstrated that ctDNA clearance correlated with complete response but ctDNA increases preceded radiological relapses. ctDNA exhibited high concordance with tumor biopsy in detecting genetic aberrations and demonstrated potential as a promising noninvasive approach to disease surveillance in non-DLBCL NHLs.
Journal • IO biomarker • Circulating tumor DNA
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BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1)
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Hemasalus™
28d
Nivolumab for Relapsed, Refractory, or Detectable Disease Post Chimeric Antigen Receptor T-cell Treatment in Patients With Hematologic Malignancies (clinicaltrials.gov)
P2, N=20, Active, not recruiting, University of Washington | Trial primary completion date: Apr 2025 --> Sep 2024
Trial primary completion date • CAR T-Cell Therapy
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Opdivo (nivolumab)
29d
Primary hepatic mucosa-associated lymphoid tissue lymphoma: a case report and literature review. (PubMed, Front Oncol)
Surgical resection, in conjunction with chemotherapy, remains the cornerstone of management for this condition. The prognosis for most patients is favorable.
Review • Journal
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AFP (Alpha-fetoprotein)
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AFP elevation
1m
64Cu-LLP2A for Imaging Hematologic Malignancies (clinicaltrials.gov)
P1, N=42, Not yet recruiting, Washington University School of Medicine
New P1 trial
1m
Pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma: additional evidence to support they are a single disease with variation in the histologic spectrum. (PubMed, Virchows Arch)
Genetically, the most frequently mutated genes were TNFRSF14 (in 3 PTFLs and 2 MTTs), MAP2K1 (in 2 PTFLs, 1 PNMZL and 1 MTT), and IRF8 (in 2 MTTs and 1 PNMZL). Based on the similar or overlapping clinical, pathologic, and genetic features, PTFL and PNMZL are likely to represent two different histologic patterns of the same disease.
Journal
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MAP2K1 (Mitogen-activated protein kinase kinase 1) • IRF8 (Interferon Regulatory Factor 8) • TNFRSF14 (TNF Receptor Superfamily Member 14)
1m
Immunosuppressive tumor microenvironment in gastric signet-ring cell carcinoma. (PubMed, World J Clin Oncol)
The increased proportion of SRCC was accompanied by a decrease in mucosa-associated lymphoid tissue-derived B cells and a significant increase in follicular B cells, which may be one of the reasons for the poor prognosis of GSRCC. By understanding the relationship between immunosuppressive TME and poor prognosis in GSRCC and the underlying mechanism, more effective immunotherapy strategies and improved treatment outcomes of GSRCC can be anticipated.
Journal
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CD8 (cluster of differentiation 8) • CXCL13 (Chemokine (C-X-C motif) ligand 13)
1m
Recombinant Humanized Anti-CD47/PD-1 Bifunctional Antibody HX009 in Patients With Relapsed/Refractory Lymphoma (clinicaltrials.gov)
P1/2, N=99, Recruiting, Hangzhou Hanx Biopharmaceuticals, Ltd. | Trial completion date: Aug 2023 --> Dec 2026 | Trial primary completion date: Dec 2022 --> Dec 2025
Trial completion date • Trial primary completion date
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HX-009
1m
ARIADNE: Zanubrutinib in Patients With Waldenström's Macroglobulinemia, Chronic Lymphocytic Leukemia, Marginal Zone Lymphoma and Follicular Lymphoma (clinicaltrials.gov)
P=N/A, N=605, Recruiting, iOMEDICO AG | N=400 --> 605 | Trial completion date: Apr 2027 --> Aug 2028 | Trial primary completion date: Apr 2027 --> Aug 2028
Enrollment change • Trial completion date • Trial primary completion date
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Gazyva (obinutuzumab) • Brukinsa (zanubrutinib)
1m
MAGNIFY: Lenalidomide Plus Rituximab Followed by Lenalidomide Versus Rituximab Maintenance for Relapsed/Refractory Follicular, Marginal Zone or Mantle Cell Lymphoma. (clinicaltrials.gov)
P3, N=503, Completed, Celgene | Active, not recruiting --> Completed | Trial primary completion date: Aug 2024 --> May 2024
Trial completion • Trial primary completion date
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Rituxan (rituximab) • lenalidomide
2ms
Sonic hedgehog signaling facilitates pyroptosis in mouse heart following ischemia/reperfusion via enhancing the formation of CARD10-BCL10-MALT1 complex. (PubMed, Eur J Pharmacol)
Finally, disruption of the CBM complex prevented MALT1 from recruiting of TRAF6, which was believed to trigger the caspase-11-dependent pyroptosis. Based on these results, we conclude that inhibition of SHH signaling suppresses pyroptosis via attenuating PKCα-mediated CARD10-BCL10-MALT1 complex formation in mouse heart suffered I/R.
Preclinical • Journal
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PTCH1 (Patched 1) • MALT1 (MALT1 Paracaspase) • SHH (Sonic Hedgehog Signaling Molecule) • TRAF6 (TNF Receptor Associated Factor 6)
2ms
The Dilemma for Early-Stage Conjunctival Mucosa-Associated Lymphoid Tissue Lymphoma: To Treat or Not to Treat? (PubMed, J Pers Med)
Careful observation may be suggested for early-stage conjunctival MALToma. While more of the T1 individuals were younger and chose observation than the T2 patients, survival seemed longer in the T1 subjects without significance. CD43 may indicate shorter survival in early-stage cases.
Journal
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SPN (Sialophorin)
2ms
An Unusual Case of CD5-Positive Extranodal Marginal Zone Lymphoma of the Mucosa-Associated Lymphoid Tissue (MALT) Involving the Appendix. (PubMed, Cureus)
Lymphoma associated with thrombophilia is a rare presentation and not many cases have been reported in the literature. We present this case here on account of the rarity of lymphoma involving the appendix with associated thrombophilia.
Journal
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CD5 (CD5 Molecule)
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CD5 positive
2ms
A Study of Cirmtuzumab and Ibrutinib in Patients With B-Cell Lymphoid Malignancies (clinicaltrials.gov)
P1/2, N=102, Completed, Oncternal Therapeutics, Inc | Active, not recruiting --> Completed
Trial completion
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BCL2 (B-cell CLL/lymphoma 2)
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Imbruvica (ibrutinib) • zilovertamab (UC-961)
2ms
Dose De-escalation Study of the PI3k Alpha/Delta Inhibitor, Copanlisib Given in Combination With the Immunotherapeutic Agents, Nivolumab and Rituximab in Patients With Relapsed/Refractory Indolent Lymphoma (clinicaltrials.gov)
P1, N=6, Terminated, University of Michigan Rogel Cancer Center | N=35 --> 6 | Trial completion date: Jun 2026 --> Nov 2023 | Active, not recruiting --> Terminated | Trial primary completion date: Jun 2025 --> Nov 2023; Loss of study funding
Enrollment change • Trial completion date • Trial termination • Trial primary completion date • Combination therapy
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PD-L1 (Programmed death ligand 1)
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Opdivo (nivolumab) • Rituxan (rituximab) • Aliqopa (copanlisib)
2ms
Intraparenchymal low-grade B-cell lymphomas of the central nervous system: Clinicopathologic and molecular analysis of three cases and a review of the literature. (PubMed, Ann Diagn Pathol)
Our findings expand knowledge on their clinical and molecular features. We present the first molecular profile of primary CNS intraparenchymal EMZL, underscoring the need for further research to understand their biology and optimize treatment strategies.
Review • Journal
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ARID1A (AT-rich interaction domain 1A) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor)
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ARID1A mutation • MYD88 mutation • MYD88 L265P • SPEN mutation
2ms
In silico study of some plant compounds as potential anticancer agents targeting MALT1 allosteric domain. (PubMed, J Biomol Struct Dyn)
Our findings from this computational study presents cyanidin (-8.822 kcal/mol) as better binder to the allosteric site of MALT1 based on the molecular docking and pharmacokinetic profiling than thioridazine...Hence, cyanidin is a potential allosteric inhibitor of MALT1. However, an urgent need for in vitro and in vivo validations is required to ascertain the efficacy of cyanidin in the fight against cancer and other MALT1-related diseases.
Journal
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MALT1 (MALT1 Paracaspase)
2ms
Large B-cell lymphomas with CCND1 rearrangement have different immunoglobulin gene breakpoints and genomic profile than mantle cell lymphoma. (PubMed, Blood Cancer J)
Two cases, which transformed from marginal zone lymphomas, carried mutations in KLF2, TNFAIP3 and KMT2D. These findings expand the spectrum of tumors carrying CCND1 rearrangement that may occur as a secondary event in DLBCL mediated by aberrant CSR/SHM and associated with a mutational profile different from that of MCL.
Journal
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CCND1 (Cyclin D1) • BCL6 (B-cell CLL/lymphoma 6) • KMT2D (Lysine Methyltransferase 2D) • TNFAIP3 (TNF Alpha Induced Protein 3) • SOX11 (SRY-Box Transcription Factor 11)
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BCL6 rearrangement
2ms
NCI-2018-00315: Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma (clinicaltrials.gov)
P1, N=18, Active, not recruiting, City of Hope Medical Center | Trial completion date: Jun 2024 --> Dec 2024 | Trial primary completion date: Jun 2024 --> Dec 2024
Trial completion date • Trial primary completion date
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CCND1 (Cyclin D1) • FCER2 (Fc Fragment Of IgE Receptor II)
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Chr t(11;14) • CCND1 overexpression
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Imbruvica (ibrutinib) • pevonedistat (MLN4924)
2ms
Epstein-Barr virus-positive, primary cutaneous marginal zone lymphoma, with transformation: Case report and review of the literature. (PubMed, Am J Clin Pathol)
Transformation of EBV positive PCMZL appears to be a poor prognostic indicator, with our reported case being the first well defined case transformed to PBL, suspected to arise from myeloid-CH.
Review • Journal
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DNMT3A (DNA methyltransferase 1) • TET2 (Tet Methylcytosine Dioxygenase 2)
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DNMT3A mutation • TET2 mutation
2ms
CC-486, Lenalidomide, and Obinutuzumab for the Treatment of Recurrent or Refractory CD20 Positive B-cell Lymphoma (clinicaltrials.gov)
P1, N=8, Active, not recruiting, Joseph Tuscano | Trial completion date: Dec 2024 --> Jul 2025 | Trial primary completion date: Apr 2024 --> Dec 2024
Trial completion date • Trial primary completion date
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CD20 (Membrane Spanning 4-Domains A1) • CD4 (CD4 Molecule)
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lenalidomide • Gazyva (obinutuzumab) • Onureg (azacitidine oral)
2ms
CLOVER-WaM: Study of Iopofosine I 131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) and Pivotal Expansion in Waldenstrom Macroglobulinemia (clinicaltrials.gov)
P2, N=120, Active, not recruiting, Cellectar Biosciences, Inc. | Trial completion date: Jun 2025 --> Dec 2026 | Recruiting --> Active, not recruiting
Enrollment closed • Trial completion date
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iopofosine I-131 (CLR 131)
2ms
Enrollment change
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Zydelig (idelalisib)
2ms
New P1/2 trial
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Gazyva (obinutuzumab) • Itari (linperlisib)
2ms
Splenic marginal zone lymphoma with prolymphocytic transformation and cyclin D1 expression in the absence of CCND1 rearrangement. (PubMed, Int J Hematol)
The clinical presentation, morphology, immunophenotype, and molecular genetic findings are most consistent with a diagnosis of SMZL with prolymphocytic transformation and cyclin D1 expression. Here, we present this case along with a review of the literature, and summarize the clinicopathological characteristics of SMZL with prolymphocytic transformation.
Journal
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CCND1 (Cyclin D1) • CD5 (CD5 Molecule) • MME (Membrane Metalloendopeptidase)
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CCND1 expression
2ms
Trial completion • Combination therapy
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MSI (Microsatellite instability)
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MSI-H/dMMR
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paclitaxel • Tevimbra (tislelizumab-jsgr) • Brukinsa (zanubrutinib) • BGB-10188
2ms
Dendritic Cell Therapy, Cryosurgery, and Pembrolizumab in Treating Patients With Non-Hodgkin Lymphoma (clinicaltrials.gov)
P1/2, N=11, Active, not recruiting, Mayo Clinic | Trial completion date: Aug 2024 --> Aug 2025 | Trial primary completion date: Aug 2024 --> Aug 2025
Trial completion date • Trial primary completion date • Surgery
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CD20 negative
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Keytruda (pembrolizumab)
2ms
Polatuzumab Vedotin, Venetoclax, and Rituximab and Hyaluronidase Human for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma (clinicaltrials.gov)
P2, N=3, Terminated, Academic and Community Cancer Research United | N=63 --> 3 | Trial completion date: Apr 2029 --> Mar 2024 | Active, not recruiting --> Terminated | Trial primary completion date: Apr 2027 --> Mar 2024; Trial closed due to low accrual rate
Enrollment change • Trial completion date • Trial termination • Trial primary completion date
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CCND1 (Cyclin D1)
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Chr t(11;14)
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Venclexta (venetoclax) • Truxima (rituximab-abbs) • Rituxan Hycela (rituximab/hyaluronidase) • Polivy (polatuzumab vedotin-piiq)
2ms
SynKIR-310 for Relapsed/Refractory B-NHL (clinicaltrials.gov)
P1, N=18, Recruiting, Verismo Therapeutics | Not yet recruiting --> Recruiting
Enrollment open
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BCL2 (B-cell CLL/lymphoma 2)