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DRUG:

Kanglaite Injection (KLTi)

i
Other names: KLTi, Kanglaite Injectie, KLT
Associations
Trials
Company:
Zhejiang Kanglaite Pharma
Drug class:
Bcl2 inhibitor, Apoptosis stimulant, NF-κB inhibitor, Fatty acid inhibitor, CD95 stimulant, Cell cycle inhibitor
Related drugs:
Associations
Trials
11ms
Efficacy and safety of Chinese medicine injections in combination with docetaxel and cisplatin for non-small cell lung cancer: a network meta-analysis. (PubMed, Front Pharmacol)
Background: Non-small cell lung cancer (NSCLC) poses a serious threat to human health. Astragalus Injection plus DP, Brucea Javanica Oil Milk Injection plus DP, Shenfu Injection plus DP, Kanglaite Injection plus DP, and Brucea Javanica Oil Milk Injection plus DP were significantly effective. However, further multicenter and well-designed RCTs are required to validate our findings.
Retrospective data • Review • Journal • Combination therapy
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CD4 (CD4 Molecule)
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cisplatin • docetaxel • Kanglaite Injection (KLTi)
over1year
Meta-analysis of the clinical effect of Kanglaite injection-assisted gemcitabine plus cisplatin regimen on non-small cell lung cancer. (PubMed, Am J Transl Res)
Current evidence shows that the combination regimen of KLT with GP has shown promising results in increasing the response rate, improving the KPS score, enhancing the immune level, and reducing the incidence of adverse reactions in NSCLC patients. However, this conclusion needs to be further verified due to limitations such as the limited number of articles included in this paper and the variability in research methodology and quality among the included studies.
Retrospective data • Review • Journal
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CD4 (CD4 Molecule)
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cisplatin • gemcitabine • Kanglaite Injection (KLTi)
over1year
Network meta-analysis of 8 types of traditional Chinese medicine injection combined with chemotherapy in colorectal cancer treatment. (PubMed, J Cancer Res Clin Oncol)
Aidi injection, Brucea javanica oil emulsion injection, compound Kushen injection, Kangai injection, Shenqi Fuzheng injection, Kanglaite injection, Shenfu injection, and Xiaoaiping injection combined with chemotherapy functioned more effectively than single chemotherapy did in colorectal cancer treatment. Nevertheless, limited by the treatment quality and methodology of different intervention measures included in the study, this conclusion is expected to be scrutinized in higher-quality and rigorously designed randomized controlled trials. PROSPERO registration No.: CRD42023392398.
Retrospective data • Review • Journal
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Kanglaite Injection (KLTi)
over1year
Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Kanglaite Injection Against Triple-Negative Breast Cancer. (PubMed, Drug Des Devel Ther)
Results from in vitro experiments showed that KLTi inhibited proliferation and migration of TNBC cell lines 231 and 468, induced apoptosis, blocked cells in the G2/M phase, downregulated the mRNA expression of seven G2/M phase-related genes cyclin-dependent kinase 1 (CDK1), cyclin-dependent kinase 2 (CDK2), and checkpoint kinase 1 (CHEK1), cell division cycle 25A (CDC25A), cell division cycle 25B (CDC25B), maternal embryonic leucine zipper kinase (MELK), and aurora kinase A (AURKA), as well as downregulated CDK1 protein expression and up-regulated protein expression of Phospho-CDK1. By utilizing network pharmacology, molecular docking, and in vitro experiments, KLTi was confirmed to have anti-TNBC effects by arresting cell cycle and inhibiting CDK1 dephosphorylation.
Journal
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AURKA (Aurora kinase A) • CHEK1 (Checkpoint kinase 1) • CDK2 (Cyclin-dependent kinase 2) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • CDC25A (Cell Division Cycle 25A) • CDC25B (Cell Division Cycle 25B) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
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Kanglaite Injection (KLTi)
almost2years
Comparative efficacy and safety of Chinese medicine injections combined with capecitabine and oxaliplatin chemotherapies in treatment of colorectal cancer: A bayesian network meta-analysis. (PubMed, Front Pharmacol)
The top three in terms of improving performance status were Xiaoaiping, Shenmai, and Kanglaite injections. Nevertheless, additional results from multicenter trials and high-quality studies will bevital to support our findings. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=326097, CRD42022326097.
Retrospective data • Review
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CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
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capecitabine • oxaliplatin • Kanglaite Injection (KLTi)
4years
Coix Seed Oil Exerts an Anti-Triple-Negative Breast Cancer Effect by Disrupting miR-205/S1PR1 Axis. (PubMed, Front Pharmacol)
Kanglaite Injection, a commercial product of CSO, has been used clinically as an anticancer drug in China for decades...CSO reduced the expression of S1PR1, cyclinD1, and phosphorylation levels of STAT3, MAPK, and AKT while upregulated p27. These results revealed that CSO exerted an anti-TNBC effect via the miR-205/S1PR1 axis to regulate sphingomyelin metabolism, and the downstream STAT3/MAPK/AKT signal pathways were partly involved.
Journal
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CCND1 (Cyclin D1) • STAT3 (Signal Transducer And Activator Of Transcription 3)
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CCND1 expression
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Kanglaite Injection (KLTi)
4years
Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κB pathway and regulating transporter mediated drug efflux. (PubMed, J Ethnopharmacol)
KLT pretreatment may increase the effects of CDDP on HepG2 cells, by exhibiting cooperative effects on suppression of HepG2 cells. The mechanisms may partly by inhibiting CKLF1 mediated NF-κB pathway, which may contribute to inflammation of tumor microenvironment and chemoresistance of CDDP. Inhibition of transporter-mediated drug efflux is also involved in KLT mediated sensitization effects of CDDP.
Clinical • Journal
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TNFA (Tumor Necrosis Factor-Alpha) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1)
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cisplatin • Kanglaite Injection (KLTi)