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DRUG:
istiratumab (MM-141)
i
Other names:
MM-141, MM 141
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Associations
News
Trials
Company:
Ipsen
Drug class:
HER3 inhibitor, IGF-1R inhibitor
Related drugs:
‹
MCLA-128 (16)
MM-121 (12)
Ac-225 ErbB3 targeted radiotherapy (4)
ISU104 (4)
AV-203 (1)
LJM-716 (1)
SI-B001 (1)
U3-1287 (1)
177Lu-HER3 ARC (0)
CDX-3379 (0)
GSK2849330 (0)
MM 111 (0)
Sym013 (0)
INCB7839 (0)
MEHD7945A (0)
RG7116 (0)
AZD8931 (0)
BMS-754807 (10)
AMG 479 (10)
ASP7487 (7)
AZD3463 (2)
GSK 1838705A (2)
SY-707 (1)
CP-751,871 (1)
BMS-536924 (0)
FPI-1434 (0)
IGV-001 (0)
KW-2450 (0)
LX-101 (0)
NVP-ADW742 (0)
NVP-AEW541 (0)
NVP-TAE226 (0)
teprotumumab-trbw (0)
XL228 (0)
IMC A12 (0)
MK 0646 (0)
MEDI-573 (0)
AXL1717 (0)
SCH 717454 (0)
MCLA-128 (16)
MM-121 (12)
Ac-225 ErbB3 targeted radiotherapy (4)
ISU104 (4)
AV-203 (1)
LJM-716 (1)
SI-B001 (1)
U3-1287 (1)
177Lu-HER3 ARC (0)
CDX-3379 (0)
GSK2849330 (0)
MM 111 (0)
Sym013 (0)
INCB7839 (0)
MEHD7945A (0)
RG7116 (0)
AZD8931 (0)
BMS-754807 (10)
AMG 479 (10)
ASP7487 (7)
AZD3463 (2)
GSK 1838705A (2)
SY-707 (1)
CP-751,871 (1)
BMS-536924 (0)
FPI-1434 (0)
IGV-001 (0)
KW-2450 (0)
LX-101 (0)
NVP-ADW742 (0)
NVP-AEW541 (0)
NVP-TAE226 (0)
teprotumumab-trbw (0)
XL228 (0)
IMC A12 (0)
MK 0646 (0)
MEDI-573 (0)
AXL1717 (0)
SCH 717454 (0)
›
Associations
News
Trials
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Latest
almost4years
Randomized, double-blind, placebo-controlled phase II study of istiratumab (MM-141) plus nab-paclitaxel and gemcitabine versus nab-paclitaxel and gemcitabine in front-line metastatic pancreatic cancer (CARRIE). (PubMed, Ann Oncol)
Istiratumab failed to improve the efficacy of SOC chemotherapy in this patient setting. High serum IGF-1 levels did not appear to be an adverse prognostic factor when compared with non-biomarker-selected historic controls.
almost 4 years ago
Clinical • P2 data • Journal
|
ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3)
|
gemcitabine • albumin-bound paclitaxel • istiratumab (MM-141)
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