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    BIOMARKER:

    GNAQ mutation + GNA11 mutation

    i
    Other names: GNAQ, G Protein Subunit Alpha Q, Guanine Nucleotide Binding Protein (G Protein) Q Polypeptide, Guanine Nucleotide-Binding Protein G(Q) Subunit Alpha, Guanine Nucleotide-Binding Protein Alpha-Q, GAQ, Epididymis Secretory Sperm Binding Protein, G-ALPHA-Q, CMC1, SWS, GNA11, G Protein Subunit Alpha 11, Guanine Nucleotide Binding Protein (G Protein) Alpha 11 (Gq Class), Guanine Nucleotide-Binding Protein G(Y) Subunit Alpha, Guanine Nucleotide-Binding Protein Subunit Alpha-11, G Alpha-11, Hypocalciuric Hypercalcemia 2, G-Protein Subunit Alpha-11, GNA-11, HYPOC2, FBH2, FHH2, HHC2, GA11, FBH
    Entrez ID:
    2776; 2767
    Related biomarkers:
    Mutation
    8d
    GNAQ/GNA11-Related Benign and Malignant Entities-A Common Histoembriologic Origin or a Tissue-Dependent Coincidence. (PubMed, Cancers (Basel))
    Moreover, we discuss the role of SOX10-positive perivascular cells that may be implicated in the complex pathophysiology of GNAQ/GNA11-related entities. Understanding the common molecular foundation of these conditions opens new ways for research and treatment opportunities, potentially leading to more effective, personalized therapeutic strategies.
    Review • Journal
    |
    GNAQ (G Protein Subunit Alpha Q) • GNA11 (G Protein Subunit Alpha 11) • SOX10 (SRY-Box 10)
    |
    GNAQ mutation • GNA11 mutation • GNAQ mutation + GNA11 mutation
    over1year
    Genomic profiling of uveal melanoma patients using the GENIE database (AACR 2023)
    GNAQ and GNA11 mutations were identified to be the most frequent mutations among UM patients, with a mutual exclusivity relationship between the two genes. New therapeutic modalities should consider the comprehensive genomic profiling of UM patients to improve their overall survival rate and quality of life.
    Clinical
    |
    GNAQ (G Protein Subunit Alpha Q) • SF3B1 (Splicing Factor 3b Subunit 1) • BAP1 (BRCA1 Associated Protein 1) • GNA11 (G Protein Subunit Alpha 11) • CHEK2 (Checkpoint kinase 2) • EIF1AX (Eukaryotic Translation Initiation Factor 1A X-Linked)
    |
    GNAQ mutation • GNA11 mutation • BAP1 mutation • GNAQ mutation + GNA11 mutation