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    BIOMARKER:

    GNAQ mutation + GNA11 mutation

    i
    Other names: GNAQ, G Protein Subunit Alpha Q, Guanine Nucleotide Binding Protein (G Protein) Q Polypeptide, Guanine Nucleotide-Binding Protein G(Q) Subunit Alpha, Guanine Nucleotide-Binding Protein Alpha-Q, GAQ, Epididymis Secretory Sperm Binding Protein, G-ALPHA-Q, CMC1, SWS, GNA11, G Protein Subunit Alpha 11, Guanine Nucleotide Binding Protein (G Protein) Alpha 11 (Gq Class), Guanine Nucleotide-Binding Protein G(Y) Subunit Alpha, Guanine Nucleotide-Binding Protein Subunit Alpha-11, G Alpha-11, Hypocalciuric Hypercalcemia 2, G-Protein Subunit Alpha-11, GNA-11, HYPOC2, FBH2, FHH2, HHC2, GA11, FBH
    Entrez ID:
    2776; 2767
    Related biomarkers:
    Mutation
    1year
    Genomic profiling of uveal melanoma patients using the GENIE database (AACR 2023)
    GNAQ and GNA11 mutations were identified to be the most frequent mutations among UM patients, with a mutual exclusivity relationship between the two genes. New therapeutic modalities should consider the comprehensive genomic profiling of UM patients to improve their overall survival rate and quality of life.
    Clinical
    |
    GNAQ (G Protein Subunit Alpha Q) • SF3B1 (Splicing Factor 3b Subunit 1) • BAP1 (BRCA1 Associated Protein 1) • GNA11 (G Protein Subunit Alpha 11) • CHEK2 (Checkpoint kinase 2) • EIF1AX (Eukaryotic Translation Initiation Factor 1A X-Linked)
    |
    GNAQ mutation • GNA11 mutation • BAP1 mutation • GNAQ mutation + GNA11 mutation