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DRUG:

FS118

i
Other names: FS118, FS-118, FS 118
Company:
Sino Biopharm
Drug class:
PD-L1 inhibitor, LAG-3 inhibitor
Related drugs:
4ms
A Phase 1/2 Study of FS118 in Patients With Advanced Malignancies (clinicaltrials.gov)
P1/2, N=80, Terminated, invoX Pharma Limited | Active, not recruiting --> Terminated; Business Decision
Trial termination • Combination therapy • Metastases
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LAG3 (Lymphocyte Activating 3)
|
paclitaxel • FS118
over1year
A Phase 1/2 Study of FS118 in Patients With Advanced Malignancies (clinicaltrials.gov)
P1/2, N=95, Active, not recruiting, invoX Pharma Limited | Recruiting --> Active, not recruiting | Trial completion date: Dec 2022 --> Jun 2024 | Trial primary completion date: Dec 2022 --> Jun 2024
Enrollment closed • Trial completion date • Trial primary completion date
|
LAG3 (Lymphocyte Activating 3)
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paclitaxel • FS118
2years
A Phase 1 first-in-human study of FS118, a tetravalent bispecific antibody targeting LAG-3 and PD-L1 in patients with advanced cancer and PD-L1 resistance. (PubMed, Clin Cancer Res)
FS118 was well tolerated with no DLTs observed up to and including 20 mg/kg QW. Further studies are warranted to determine clinical benefit in patients who have become refractory to anti-PD-(L)1 therapy.
P1 data • Journal
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LAG3 (Lymphocyte Activating 3)
|
FS118
2years
Durable response of anaplastic thyroid carcinoma to FS118, a bispecific LAG-3/PD-L1 antibody, after checkpoint inhibitor progression: a case report. (PubMed, J Immunother Cancer)
Simultaneously, expanded use should be considered for those with refractory disease, especially if PD-L1 positive. Insights Dual PD-L1/LAG-3 blockade may be an effective treatment strategy for refractory metastatic tumors, including anaplastic thyroid cancer.
Journal • Checkpoint inhibition • PD(L)-1 Biomarker • IO biomarker
|
LAG3 (Lymphocyte Activating 3)
|
PD-L1 expression • BRAF V600E • BRAF V600 • PD-L1 mutation
|
FS118
almost4years
FS118 First in Human Study in Patients With Advanced Malignancies (clinicaltrials.gov)
P1/2, N=80, Recruiting, F-star Delta Limited | Active, not recruiting --> Recruiting | Phase classification: P1 --> P1/2 | N=43 --> 80 | Trial completion date: Dec 2020 --> Dec 2022 | Trial primary completion date: Dec 2020 --> Dec 2022
Clinical • Enrollment open • Phase classification • Enrollment change • Trial completion date • Trial primary completion date
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LAG3 (Lymphocyte Activating 3)
|
FS118
4years
[VIRTUAL] A first-in-human study of FS118, a tetravalent bispecific antibody targeting LAG-3 and PD-L1, in patients with advanced cancer and resistance to PD-(L)1 therapy (SITC 2020)
Conclusions Weekly treatment with FS118 was well tolerated up to 20 mg/kg and was associated with pharmacodynamic markers of FS118 activity. Encouraging signs of clinical activity were observed in highly pre-treated patients who had acquired resistance to prior PD-(L)1 therapy.
Clinical • P1 data • PD(L)-1 Biomarker • IO biomarker
|
LAG3 (Lymphocyte Activating 3)
|
PD-L1 expression • LAG3 expression
|
FS118
4years
[VIRTUAL] A first-in-human study of FS118, a tetravalent bispecific antibody targeting LAG-3 and PD-L1, in patients with advanced cancer and resistance to PD-(L)1 therapy (SITC 2020)
Conclusions Weekly treatment with FS118 was well tolerated up to 20 mg/kg and was associated with pharmacodynamic markers of FS118 activity. Encouraging signs of clinical activity were observed in highly pre-treated patients who had acquired resistance to prior PD-(L)1 therapy.
Clinical • P1 data • PD(L)-1 Biomarker • IO biomarker
|
LAG3 (Lymphocyte Activating 3)
|
PD-L1 expression • LAG3 expression
|
FS118