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    almost3years
    A multicenter-retrospective study of non-small-cell lung carcinoma harboring uncommon epidermal growth factor receptor (EGFR) mutations: different subtypes of EGFR exon 19 deletion-insertions exhibit the clinical characteristics and prognosis of non-small cell lung carcinoma. (PubMed, Transl Lung Cancer Res)
    The EGFR exon 19 deletion-insertion mutations exhibited limited sensitivity to 3rd generation TKI. Moreover, in light of therapeutic effect for the subtype, L747_T751delinsP achieved longer PFS.
    Retrospective data • Journal
    |
    EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • RB1 (RB Transcriptional Corepressor 1) • NAPSA (Napsin A Aspartic Peptidase)
    |
    TP53 mutation • EGFR mutation • PIK3CA mutation • EGFR exon 19 deletion • EGFR E746_S752delinsV • EGFR L747_A750delinsP • EGFR E746 • EGFR L747_P753delinsS • EGFR L747_T751delinsP