doxorubicin hydrochloride

Our analyses reveal that Tan IIA regulates 13 core targets of Dox cardiotoxicity-with enrichment in pathways including canonical cancer and small cell lung cancer pathways-and that six of these targets exhibit high binding affinity for Tan IIA or Dox; notably, machine learning prioritized the histone methyltransferase EZH2 as the central target for Tan IIA's anti-TNBC activity, and we further show EZH2 is highly expressed in breast invasive carcinoma (BRCA) tissues and correlates positively with infiltration of immune cells (e.g., B cells, CD4⁺ T cells) and expression of immune-related molecules (including immunosuppressors and MHC-associated antigen-presenting molecules). Collectively, these findings demonstrate that Tan IIA may mitigate Dox cardiotoxicity via modulation of targets such as APAF1, AR, and TERT (and their associated signaling cascades) while targeting EZH2 to exert anti-TNBC effects, providing a mechanistic framework for repurposing Tan IIA to improve the safety and efficacy of Dox-based BC therapy.

Furthermore, treatment with AVD (adriamycin/vinblastine/dacarbazine) in combination with brentuximab vedotin (BV) was initiated to achieve a complete metabolic response. Histopathologically, SV has a high proportion of HRS cells, with high CD30-positive and low EBER-positive rates. Therefore, CD30-targeted therapies such as BV may be preferable for SV, even in localized NS-HL patients, thereby improving patient prognosis.

P1/2, N=90, Recruiting, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | N=150 --> 90

P2, N=80, Not yet recruiting, Sun Yat-sen University

P2, N=30, Recruiting, University of Washington | Not yet recruiting --> Recruiting

P3, N=160, Active, not recruiting, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Recruiting --> Active, not recruiting

P=N/A, N=46, Recruiting, Thyroid and Breast Surgery Department of North Sichuan Medical College Affiliated Hospital; North Sichuan Medical College Affiliated Hospital

P3, N=120, Not yet recruiting, West China Hospital, Sichuan University; West China Hospital, Sichuan University

Dox resistance in DLBCL was mediated by P300-facilitated glycolysis.

SRT-1720 induces oxidative stress and apoptosis in leukemic lymphocytes through SIRT1-independent pathway(s). In contrast, it enhances antioxidant defense in normal lymphocytes through a SIRT1-dependent pathway. These findings highlight the potential of SRT-1720 as an adjuvant to chemotherapy in T-ALL, particularly in drug combinations demonstrating strong synergism, which may allow dose reduction and decreased toxicity.

Moreover, PE loaded PEC/ALG NPs showed good biocompatibility as confirmed by histopathological, biochemical, and hematological assessments. This study reports the fabrication of PE loaded PEC/ALG NPs with promising potential against DOX-induced testicular toxicity, highlighting a novel biocompatible nanoformulation to protect male fertility during chemotherapy.

The autophagy-mediated suppression of the HIF-1α signaling pathway blocks metastasis of HCC. The present research provides a novel approach for cancer TACE therapy with embolic microspheres.