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BIOMARKER:

DNMT3A deletion

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Entrez ID:

Related biomarkers:

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DNMT3A mutation (28)

DNMT3A mutation + FLT3-ITD mutation (4)

DNMT3A R882H (3)

FLT3 mutation + DNMT3A mutation (3)

FLT3‐ITD mutation + DNMT3A mutation + NPM1 mutation (3)

DNMT3A mutation + NPM1 mutation (2)

NPM1 mutation + DNMT3A mutation (2)

DNMT3A R882 (1)

DNMT3A mutation + ASXL1 mutation (1)

DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

DNMT3A mutation + IDH mutation (1)

DNMT3A mutation + NRAS mutation (1)

DNMT3A mutation + SF3B1 mutation (1)

DNMT3A rs11681717 (1)

FLT3-ITD mutation + DNMT3A mutation + ASXL1 mutation (1)

FLT3-ITD mutation + DNMT3A mutation + NRAS mutation (1)

FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

FLT3‐ITD + DNMT3A mutation (1)

KRAS G12D + DNMT3A C559fsX (1)

NPM1 mutation + DNMT3A mutation + KMT2D mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

SRSF2 mutation + DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

TET2 mutation + DNMT3A mutation (0)

DNMT3A mutation (28)

DNMT3A mutation + FLT3-ITD mutation (4)

DNMT3A R882H (3)

FLT3 mutation + DNMT3A mutation (3)

FLT3‐ITD mutation + DNMT3A mutation + NPM1 mutation (3)

DNMT3A mutation + NPM1 mutation (2)

NPM1 mutation + DNMT3A mutation (2)

DNMT3A R882 (1)

DNMT3A mutation + ASXL1 mutation (1)

DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

DNMT3A mutation + IDH mutation (1)

DNMT3A mutation + NRAS mutation (1)

DNMT3A mutation + SF3B1 mutation (1)

DNMT3A rs11681717 (1)

FLT3-ITD mutation + DNMT3A mutation + ASXL1 mutation (1)

FLT3-ITD mutation + DNMT3A mutation + NRAS mutation (1)

FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

FLT3‐ITD + DNMT3A mutation (1)

KRAS G12D + DNMT3A C559fsX (1)

NPM1 mutation + DNMT3A mutation + KMT2D mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

SRSF2 mutation + DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

TET2 mutation + DNMT3A mutation (0)

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almost3years

Augmented Txnip-p53-p21 axis preserves Dnmt3a mutant hematopoietic stem cells during inflammatory stress (AACR 2022)

Functionally, knocking down Txnip and p21 sensitized Dnmt3aKO HSCs to IFNg-induced cell cycle activation ex vivo. In vivo, down-regulation of p21 had no effect on control HSCs in response to IFNg exposure, but it completely primed Dnmt3aKO and Dnmt3aR878 HSCs to IFNg-associated exhaustion in a transplantation experiment.In summary, our data suggest an augmented Txnip-p53-p21 axis preserves the functional potential of Dnmt3a-mutant HSCs under inflammatory stress, which highlights a novel mechanism to explain the increased fitness of Dnmt3a-mutant HSCs and supports rationale for developing interventions to mitigate expansion of pre-malignant clones as a method of blood cancer prevention.

almost 3 years ago

Late-breaking abstract

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DNMT3A (DNA methyltransferase 1) • IFNG (Interferon, gamma) • TXNIP (Thioredoxin Interacting Protein)

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DNMT3A mutation • DNMT3A deletion