Cutaneous T-cell Lymphoma

Collectively, these findings have significant implications for the rationale design of combinatorial strategies targeting immune checkpoints, including PD-1. We have identified transcriptional programs, driven by oncogenic transcription factors, and constituents of the TME as therapeutic vulnerabilities in CTCL, and hope that the CTCL atlas constructed will provide a valuable resource for future studies exploiting these therapeutic vulnerabilities.

This report explores the clinical and histological manifestations of GMF, features distinguishing GMF from other granulomatous diseases, such as IGD, and the prognostic significance of distinguishing GMF from classic mycosis fungoides. We aimed to raise awareness among physicians regarding this rare disease and emphasize the characteristic histological features of GMF that can be confused with other types of mycosis fungoides.

P=N/A, N=73, Completed, Kyowa Kirin Pharmaceutical Development Ltd | Active, not recruiting --> Completed

We emphasize the importance of clinical-pathological correlation, with clonality studies playing a crucial role in some cases. Management strategies are briefly reviewed, ranging from skin-directed therapies like phototherapy and corticosteroids to systemic treatments for more aggressive forms of leukemia cutis and lymphomas.

These results provide new insights into advanced MF tumorigenesis and show that the effects of IL4Rα blockade are specific to the STAT6 pathway, inhibiting proliferation of malignant lymphocytes, as well as repressing several immunosuppressive mechanisms within the MF TME. However, the extensive genetic, transcriptional, and functional heterogeneity across MF patients indicates that inhibition of multiple driver pathways and a personalized therapeutic approach will be important for developing new therapeutic strategies against this disease.

P2, N=35, Not yet recruiting, Peking University First Hospital

After nivolumab discontinuation and transition to avelumab, the patient experienced complete metabolic resolution of cardiac involvement, improvement in cardiac biomarkers, and durable control of cutaneous lymphoma over more than 3 years of follow-up. This case highlights a temporal association between programmed cell death-1 blockade and atypical dissemination of cutaneous T-cell lymphoma, supported by biologic plausibility, and underscores a potential therapeutic distinction between programmed cell death-1 and programmed death ligand-1 inhibition in malignant T-cell disorders.

The finding of this cohort study suggest that adult HMF demonstrated a generally indolent course, with favorable response to skin-directed therapy, irrespective of immunophenotype or mixed-variant presentation. Peripheral blood TCR monoclonality was associated with lower treatment response but not disease progression.

P1, N=45, Active, not recruiting, Baylor College of Medicine | Recruiting --> Active, not recruiting | N=27 --> 45 | Trial completion date: May 2040 --> Mar 2041

Given the lesion's location in a cosmetically sensitive area, care was coordinated with dermatology, hematology/oncology, and plastic surgery. This case highlights the importance of clinicopathologic correlation in distinguishing PCSM-TCLPD from its malignant mimickers and in guiding appropriate management.

P1/2, N=78, Recruiting, City of Hope Medical Center | Active, not recruiting --> Recruiting | N=38 --> 78