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BIOMARKER:

AFP elevation

i
Other names: AFP, Alpha-fetoprotein, FETA, HPAFP
Entrez ID:
Related biomarkers:
11h
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery (clinicaltrials.gov)
P3, N=537, Active, not recruiting, Children's Oncology Group | Trial completion date: Jun 2026 --> Dec 2026 | Trial primary completion date: Jun 2026 --> Dec 2026
Trial completion date • Trial primary completion date • Surgery
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SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • AFP (Alpha-fetoprotein)
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AFP elevation
|
cisplatin • carboplatin • gemcitabine • sorafenib • doxorubicin hydrochloride • oxaliplatin • etoposide IV • irinotecan • vincristine • daunorubicin • fluorouracil topical
3d
Retrospective data • Journal
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AFP (Alpha-fetoprotein)
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AFP elevation
7d
Nomogram for predicting testicular yolk sac tumor in children based on age, alpha-fetoprotein, and ultrasonography. (PubMed, Front Pediatr)
The Brier score of the nomogram was 0.0002. A nomogram based on age, AFP levels, and ultrasound blood flow signals can effectively predict the probability of testicular yolk sac tumor preoperatively, aiding in clinical decision-making and patient counseling.
Journal
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AFP (Alpha-fetoprotein)
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AFP elevation
19d
Outcomes of Pediatric Hepatocellular Carcinoma: A Single-Center Experience With Resection Versus Transplantation. (PubMed, Pediatr Transplant)
These findings emphasize the need for comprehensive pediatric surgical guidelines for HCC. We recommend LT over LR in pediatric cases. Extrahepatic disease post-neoadjuvant chemotherapy remains the only absolute contraindication.
Clinical • Retrospective data • Journal
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AFP (Alpha-fetoprotein)
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AFP elevation
20d
Giant cystic lymphangioma as a rare cause of acute abdomen in infancy: a case report and literature review. (PubMed, Folia Med (Plovdiv))
Giant abdominal lymphangiomas in infants are extremely rare and close attention for complications is vital. Surgical intervention with complete resection is considered the optimal management.
Review • Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
1m
Early Outcomes of the Surgical Treatment of Sacrococcygeal Tumors in a Tertiary Level Government Hospital. (PubMed, Acta Med Philipp)
The sacral approach for SCT excision was employed for the great majority of our patients, but due to the advanced age at diagnosis and locally advanced disease, morbidities occurred in about a third of the patients. Therefore, early detection prenatally and early referral to a pediatric surgical center should be achievable goals for physicians dealing with these patients.
Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
1m
The Neoangiogenic Transcriptomic Signature Impacts Hepatocellular Carcinoma Prognosis and Can Be Triggered by Transarterial Chemoembolization Treatment. (PubMed, Cancers (Basel))
Notably, the nTS can develop after repeated TACE procedures, significantly impacting patient survival and altering oncogenic microRNA expression patterns. These findings highlight the critical role of the nTS in guiding treatment decisions and prognostication in HCC management.
Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
2ms
Primary hepatic mucosa-associated lymphoid tissue lymphoma: a case report and literature review. (PubMed, Front Oncol)
Surgical resection, in conjunction with chemotherapy, remains the cornerstone of management for this condition. The prognosis for most patients is favorable.
Review • Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
2ms
Prognostic Impact of the Cholangiolar Component in Combined Hepatocellular-Cholangiocarcinoma: Insights From a Western Single-Center Study. (PubMed, J Surg Oncol)
Histological evaluation should actively incorporate the search for a cholangiolar component in primary liver tumors to prevent misdiagnosis, as its presence indicates a poorer prognosis.
Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
2ms
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery (clinicaltrials.gov)
P3, N=537, Active, not recruiting, Children's Oncology Group | Phase classification: P2/3 --> P3
Phase classification • Surgery
|
SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • AFP (Alpha-fetoprotein)
|
AFP elevation
|
cisplatin • carboplatin • gemcitabine • sorafenib • doxorubicin hydrochloride • oxaliplatin • etoposide IV • irinotecan • vincristine • daunorubicin • fluorouracil topical
2ms
SWENOTECA-ABC: Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer (clinicaltrials.gov)
P3, N=348, Active, not recruiting, St. Olavs Hospital | Trial completion date: Dec 2035 --> May 2032 | Trial primary completion date: Dec 2035 --> May 2027 | Recruiting --> Active, not recruiting
Enrollment closed • Trial completion date • Trial primary completion date
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AFP (Alpha-fetoprotein)
|
AFP elevation
|
cisplatin • carboplatin • etoposide IV • bleomycin
2ms
The Role of Lactate Dehydrogenase in Exploring the Immune Evasion in HCC Patients Who Underwent TACE: Implications for Clinical Application. (PubMed, J Hepatocell Carcinoma)
sPD-L1 levels were higher in patients with vascular invasion than those without vascular invasion at 3 and 7 days post-TACE, in the SD group compared to CR and PR groups at 3 and 7 days post-TACE, and in those with tumor > 5 cm compared to those with tumor < 5 cm at 3 and 7 days after TACE (all P < 0.05). A positive correlation was found between LDH expression and sPD-L1 levels, suggesting LDH as a potential biomarker for assessing immune status in HCC patients following TACE.
Journal
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PD-L1 (Programmed death ligand 1) • AFP (Alpha-fetoprotein)
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PD-L1 expression • AFP elevation
2ms
An Ovarian Sertoli-Leydig Cell Tumor with Elevated Alpha-Fetoprotein in an Adolescent: A Rare Case Report and Literature Review. (PubMed, Medicina (Kaunas))
This report presents a detailed description of the findings, differential diagnosis, clinical course, chosen treatment, and prognosis. Also, a comprehensive literature review of ovarian Sertoli-Leydig cell tumors, focusing on their clinical presentation, laboratory findings, macroscopic and histopathological features, genetics, clinical management, prognostic factors and follow-up, is provided.
Review • Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
2ms
Can Dynamic Contrast-Enhanced MRI Be Used to Differentiate Hepatic Hemangioma from Other Lesions in Early Infancy? (PubMed, Indian J Radiol Imaging)
There was no significant difference in alpha-fetoprotein elevation ( p 0.08), average size ( p 0.35), multifocality ( p 0.38), and intralesional hemorrhage ( p 1) between hemangioma and hepatoblastoma. Conclusion  Centripetal filling on dynamic imaging and absence of washout are characteristic MRI features of hepatic hemangioma that can help to differentiate it from other lesions in early infancy.
Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
3ms
Identification of novel M2 macrophage-related molecule ATP6V1E1 and its biological role in hepatocellular carcinoma based on machine learning algorithms. (PubMed, J Cell Mol Med)
In vitro assays demonstrated that ATP6V1E1 knockdown markedly inhibited the proliferation of HCC cells. The study underscores the significance of M2 macrophages and ATP6V1E1 in HCC, highlighting their potential as therapeutic and prognostic targets.
Journal • Machine learning
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AFP (Alpha-fetoprotein)
|
AFP elevation
7ms
Clinical Characteristics of Non-B and Non-C Biopsy-Proven Primary Liver Cancers in an HBV- Endemic Area: A Retrospective Study. (PubMed, J Hepatocell Carcinoma)
Female patients with biliary inflammatory diseases and higher CA199 levels had an increased risk of ICC, and patients with metabolic risk factors and elevated AFP levels were more likely to develop HCC. Additional research should be performed to verify this finding.
Retrospective data • Journal • Biopsy
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CA 19-9 (Cancer antigen 19-9)
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AFP elevation
8ms
Lean body mass index is a marker of advanced tumor features in patients with hepatocellular carcinoma. (PubMed, World J Hepatol)
Lean patients with cirrhosis and HCC present with larger tumors and are more often outside Milan criteria, reflecting cancer related cachexia from delayed diagnosis. Access to care for hepatitis C virus therapy and liver transplantation confer a survival benefit, but not overweight or obese BMI classifications.
Journal • Metastases
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AFP (Alpha-fetoprotein)
|
AFP elevation
8ms
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer (clinicaltrials.gov)
P3, N=236, Active, not recruiting, National Cancer Institute (NCI)
Trial completion date
|
AFP (Alpha-fetoprotein)
|
AFP elevation
|
cisplatin • doxorubicin hydrochloride • irinotecan • Torisel (temsirolimus) • vincristine • fluorouracil topical • dexrazoxane
8ms
CEUS in prediction of early recurrence of hepatocellular carcinoma after curative resection and to stratify the risk of early recurrence: a retrospective observational study. (PubMed, Abdom Radiol (NY))
Tumor size ≥ 30 mm and satellite nodules seen on CEUS, DL radiomics reoccurrence score based on the frame of image with the maximum intensity of CEUS and an elevated alpha-fetoprotein level can predict ER of HCC.
Observational data • Retrospective data • Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
8ms
Surgical Intervention After Lenvatinib Treatment in Patients With Advanced Hepatocellular Carcinoma. (PubMed, Anticancer Res)
Surgical intervention after lenvatinib treatment for advanced HCC was associated with longer PFS. Patients exhibiting decreased AFP levels or maintaining AFP levels within the normal limit may be suitable candidates for surgical intervention after lenvatinib treatment for advanced HCC.
Journal • Metastases
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AFP (Alpha-fetoprotein)
|
AFP elevation
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Lenvima (lenvatinib)
8ms
The Utility of Serum Alpha-fetoprotein for Monitoring for Relapse of Alpha-fetoprotein-Positive Hepatoblastoma. (PubMed, J Pediatr Hematol Oncol)
Treatment typically involves surgery and cisplatin-based chemotherapy...Little primary data supports, such a practice, however, and herein we present both our institutional experience with relapsed hepatoblastoma and a careful review of published literature on this topic. While serial AFP monitoring may suffice for most patients, certain clinical characteristics should give pause to the practitioner, when considering posttreatment monitoring with serum AFP alone.
Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
|
cisplatin
8ms
Detecting microvascular invasion in hepatocellular carcinoma using the impeded diffusion fraction technique to sense macromolecular coordinated water. (PubMed, Abdom Radiol (NY))
IDF-DWI shows great potential in noninvasively, accurately, and preoperatively detecting MVI in HCC and may offer clinical benefits for prognostic prediction and determination of treatment strategy.
Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
9ms
A Prompt Diagnosis and Treatment of a Case of Nuclear Protein of the Testis Carcinoma Characterized by a Bronchial Lesion and High Serum Alpha-fetoprotein Level Following Genomic Testing. (PubMed, Intern Med)
Systemic chemotherapy and radiotherapy showed a temporary response, with decreased serum alpha-fetoprotein levels. We highlight this case of a prompt diagnosis by NGS of NUTC in a young individual with a rapidly progressing tumor.
Journal
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AFP (Alpha-fetoprotein) • BRD4 (Bromodomain Containing 4) • NUTM1 (NUT Midline Carcinoma Family Member 1)
|
AFP elevation
10ms
Clinical Characteristics and Survival of Hepatocellular Carcinoma: Insights from Single-Centre Experience in Saudi Arabia. (PubMed, Cureus)
Higher AFP (>400 ng/mL), relapse, abdominal ascites, and a higher cancer CLIP score were associated with poorer outcomes. Targeted screening and health education should be advocated; in addition, social determinants should be proactively addressed.
Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
10ms
RARE INTRACRANIAL MULTIFOCAL NON-GERMINOMATOUS GERM CELL TUMOR IN AN 18-YEAR-OLD MALE: A CASE REPORT. (PubMed, Acta Clin Croat)
In selected cases, biopsy may not be indicated to start adjuvant chemotherapy. We emphasize the importance of specific treatment modality selection based mainly on tumor markers, regardless of the precise histologic classification.
Clinical • Observational data • Retrospective data • Review • Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
10ms
Clonorchis sinensis infection amplifies hepatocellular carcinoma stemness, predicting unfavorable prognosis. (PubMed, PLoS Negl Trop Dis)
HCC patients with C. sinensis infection exhibit a poor prognosis following hepatectomy. Moreover, C. sinensis infection promotes the acquisition of cancer stem cell-like characteristics, consequently accelerating the malignant progression of HCC.
Retrospective data • Journal
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AFP (Alpha-fetoprotein) • EPCAM (Epithelial cell adhesion molecule) • KRT19 (Keratin 19) • CA 19-9 (Cancer antigen 19-9)
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AFP elevation • EPCAM expression
10ms
A rare case of hepatoid gastric adenocarcinoma. (PubMed, Rev Esp Enferm Dig)
Given the low incidence and poor prognosis of this type of tumour, it is essential to make a correct differential diagnosis and to initiate early surgical treatment in localised stages and systemic treatment in those where the disease is disseminated. In this context, we present the case of a GHA diagnosed this year in our centre.
Journal
|
AFP (Alpha-fetoprotein)
|
AFP elevation
11ms
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery (clinicaltrials.gov)
P2/3, N=537, Active, not recruiting, Children's Oncology Group | Recruiting --> Active, not recruiting
Enrollment closed • Surgery
|
SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • AFP (Alpha-fetoprotein)
|
AFP elevation
|
cisplatin • carboplatin • gemcitabine • sorafenib • doxorubicin hydrochloride • oxaliplatin • etoposide IV • irinotecan • vincristine • daunorubicin • fluorouracil topical
11ms
A multi-parameter intrahepatic cholangiocarcinoma scoring system based on modified contrast-enhanced ultrasound LI-RADS M criteria for differentiating intrahepatic cholangiocarcinoma from hepatocellular carcinoma. (PubMed, Abdom Radiol (NY))
The modified LR-M criteria-based multi-parameter ICC scoring system had the highest specificity for diagnosing ICC and reduced the number of HCC cases diagnosed as LR-M category.
Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation
11ms
Patterns and kinetics of hepatocellular carcinoma relapse post-liver transplantation: oligorecurrence and role of local therapies. (PubMed, J Gastrointest Oncol)
There was a non-significant improvement in polyprogression-free survival (polyPFS) (median 14.0 vs. 10.7 months, P=0.1) amongst oligoM1 patients who received MDT-All compared to those who did not. Receipt of MDT-All was associated with improved OS amongst patients with limited HCC disease recurrence following liver transplantation.
Journal
|
AFP (Alpha-fetoprotein)
|
AFP elevation
11ms
Contrast-enhanced ultrasound features of hepatic sarcomatoid carcinoma different from hepatocellular carcinoma. (PubMed, Clin Hemorheol Microcirc)
CEUS features are useful in preoperative and non-invasive differentiation of hepatic sarcomatoid carcinoma and hepatocellular carcinoma.
Journal
|
AFP (Alpha-fetoprotein)
|
AFP elevation
12ms
Liver transplantation for advanced-stage primary hepatic yolk sac tumor: A case report and literature review. (PubMed, Medicine (Baltimore))
This case suggests that multimodal therapy dominated by liver transplantation, including preoperative TACE, postoperative adjuvant chemotherapy, and TRK inhibitors, is an effective treatment modality for unresectable primary hepatic YST.
Review • Journal • Metastases
|
AFP (Alpha-fetoprotein)
|
AFP elevation
|
cisplatin • Vitrakvi (larotrectinib) • etoposide IV • bleomycin
12ms
SAVIOR: Standard Versus Radiobiologically-Guided Dose Selected SBRT in Liver Cancer (clinicaltrials.gov)
P=N/A, N=110, Recruiting, Lawson Health Research Institute | Phase classification: P3 --> P=N/A
Phase classification
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AFP elevation
1year
2 years is a reasonable age cut-off level for prognostic assessment of children with hepatoblastoma. (PubMed, Eur Rev Med Pharmacol Sci)
Age is an important prognostic factor for hepatoblastoma. Age ≥ 2 years at diagnosis may predict poor prognosis and more active treatment measures can be implemented.
Journal
|
AFP (Alpha-fetoprotein)
|
AFP elevation
1year
Assessment of Predictive Efficacy of Microvascular Invasion in Hepatocellular Carcinoma Based on Preoperative Clinical Variables and Radiological Findings (RSNA 2023)
The clinical-radiological model based on preoperative clinical data and imaging features showed a good predictive performance for MVI. *Clinical Relevance/Application: We hope to provide non-invasive imaging biomarkers for the prediction of MVI for hepatocellular carcinoma through the clinical-radiological model based on preoperative clinical data and imaging features.
Clinical
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AFP (Alpha-fetoprotein)
|
AFP elevation
1year
Controversies of Direct-Acting Antivirals in Hepatocellular Carcinoma. (PubMed, Surg Oncol Clin N Am)
Overall, due to the heterogeneity among individual patient data and lack of adequately controlled data, there are no conclusive statements that can be drawn that DAAs exposure is directly associated with HCC occurrence or recurrence. However, the best available data suggest a decreased risk of incident HCC with DAA therapy and no increased risk of recurrence with DAAs after complete tumor response.
Review • Journal
|
AFP (Alpha-fetoprotein)
|
AFP elevation
1year
Preoperative prediction of microvascular invasion in hepatocellular carcinoma using diffusion-weighted imaging-based habitat imaging. (PubMed, Eur Radiol)
• This study proposed a strategy of DWI-based habitat imaging for hepatocellular carcinoma. • The habitat imaging-derived metrics can serve as diagnostic markers for identifying the microvascular invasion. • Integrating the habitat-based metric and clinical variable, a predictive nomogram was constructed and displayed high accuracy for predicting microvascular invasion.
Journal
|
AFP (Alpha-fetoprotein)
|
AFP elevation
1year
INTERFERON-RELATED GENE EXPRESSION CHANGES MEDIATED BY ALPHA-FETOPROTEIN IN PATIENTS WHO DEVELOPED HEPATOCELLULAR CARCINOMA AFTER HEPATITIS C VIRUS ERADICATION (AASLD 2023)
These results showed a correlation between the elevated AFP gene expression in hepatocellular carcinoma tissue with elevated interferon-α-related gene expression and altered VEGFA gene expression in patients with chronic liver disease with slightly elevated serum AFP levels in the range of less than 20 ng/ml. These results suggest that even a slight increase in AFP expression may have a certain impact on the hepatocellular carcinoma microenvironment.
Clinical
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AFP (Alpha-fetoprotein)
|
AFP elevation • VEGFA elevation • VEGFA expression • AFP expression
1year
Targeted Molecular Profiling of Circulating Cell-Free DNA in Patients With Advanced Hepatocellular Carcinoma. (PubMed, JCO Precis Oncol)
Tumor mutation profiling of cfDNA in HCC represents an alternative to tissue-based genomic profiling, given the high degree of tumor-plasma NGS concordance; however, genotyping of both blood and tumor may be required to detect all clinically actionable genomic alterations.
Journal • BRCA Biomarker • Metastases
|
TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • ARID1A (AT-rich interaction domain 1A) • TERT (Telomerase Reverse Transcriptase) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • TSC2 (TSC complex subunit 2) • AFP (Alpha-fetoprotein) • TSC1 (TSC complex subunit 1)
|
TP53 mutation • AFP elevation • TSC1 mutation • TSC2 mutation • TERT mutation
1year
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery (clinicaltrials.gov)
P2/3, N=537, Recruiting, Children's Oncology Group | Trial completion date: Jun 2025 --> Jun 2026 | Trial primary completion date: Jun 2025 --> Jun 2026
Trial completion date • Trial primary completion date • Surgery
|
SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • AFP (Alpha-fetoprotein)
|
AFP elevation
|
cisplatin • carboplatin • gemcitabine • sorafenib • doxorubicin hydrochloride • oxaliplatin • etoposide IV • irinotecan • vincristine • daunorubicin • fluorouracil topical
1year
Surveillance and treatment of primary hepatocellular carcinoma (aka. STOP HCC): protocol for a prospective cohort study of high-risk patients for HCC using GALAD-score. (PubMed, BMC Cancer)
The present work will evaluate the performance of GALAD score in early detection of liver cancer. Furthermore, by leveraging the prospective cohort, we will establish a biorepository of longitudinally collected biospecimens from patients with advanced fibrosis or cirrhosis to be used as a reference set for future research in early detection of HCC in the two countries.
Journal
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AFP (Alpha-fetoprotein)
|
AFP elevation