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DRUG:

adebrelimab (SHR-1316)

i
Other names: SHR-1316, SHR 1316, HTI-1088, HTI-1316
Associations
Company:
Jiangsu Hengrui Pharma
Drug class:
PD-L1 inhibitor
Related drugs:
Associations
3d
New P2 trial • Metastases
|
Lenvima (lenvatinib) • adebrelimab (SHR-1316)
6d
New P1/2 trial • Combination therapy • Metastases
|
KRAS (KRAS proto-oncogene GTPase)
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cisplatin • carboplatin • pemetrexed • HRS-4642 • SHR-A1921 • adebrelimab (SHR-1316)
6d
SHR-A1904-301: SHR-A1904 Combinations in CLDN18.2-Positive Advanced Solid Tumor (clinicaltrials.gov)
P1, N=924, Recruiting, Shanghai Hengrui Pharmaceutical Co., Ltd. | Not yet recruiting --> Recruiting
Enrollment open • Metastases
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capecitabine • oxaliplatin • SHR-A1904 • adebrelimab (SHR-1316)
6d
RC48 Combined With Adebrelimab and Apatinib and S-1 of the Neoadjuvant Therapy of Locally Advanced Gastric Cancer (clinicaltrials.gov)
P2, N=32, Not yet recruiting, The First Affiliated Hospital with Nanjing Medical University
New P2 trial • Metastases
|
AiTan (rivoceranib) • Aidixi (disitamab vedotin) • Teysuno (gimeracil/oteracil/tegafur) • adebrelimab (SHR-1316)
9d
Chemotherapy Combined With Adebrelimab and Apatinib as the Perioperative Treatment in Patients With Biliary Tract Cancer (clinicaltrials.gov)
P2, N=40, Recruiting, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Not yet recruiting --> Recruiting
Enrollment open
|
cisplatin • gemcitabine • AiTan (rivoceranib) • adebrelimab (SHR-1316)
9d
Anti-PD-1/PD-L1 Combined With Anti-angiogenic Agents as First-line Treatment for Unresectable HCC (clinicaltrials.gov)
P2, N=111, Recruiting, Peking University Cancer Hospital & Institute | Not yet recruiting --> Recruiting | Initiation date: Apr 2024 --> Jan 2024
Enrollment open • Trial initiation date
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Avastin (bevacizumab) • AiRuiKa (camrelizumab) • AiTan (rivoceranib) • adebrelimab (SHR-1316)
13d
New P2 trial • Metastases
|
Sulanda (surufatinib) • adebrelimab (SHR-1316)
14d
New P1/2 trial • Metastases
|
Avastin (bevacizumab) • SHR-8068 • adebrelimab (SHR-1316)
20d
New P2 trial
|
Avastin (bevacizumab) • AiRuiKa (camrelizumab) • AiTan (rivoceranib) • adebrelimab (SHR-1316)
27d
New P2 trial • Metastases
|
cisplatin • adebrelimab (SHR-1316)
29d
Enrollment open
|
cisplatin • paclitaxel • capecitabine • oxaliplatin • SHR-8068 • adebrelimab (SHR-1316)
1m
New P2 trial • Combination therapy • Metastases
|
paclitaxel • AiTan (rivoceranib) • adebrelimab (SHR-1316)
1m
New P2 trial • Metastases
|
AiTan (rivoceranib) • adebrelimab (SHR-1316)
1m
New P2 trial • Combination therapy
|
trastuzumab rezetecan (SHR-A1811) • adebrelimab (SHR-1316)
1m
HS-20089 Combination Treatment in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
P1, N=1048, Not yet recruiting, Hansoh BioMedical R&D Company
New P1 trial • Metastases
|
Avastin (bevacizumab) • cisplatin • carboplatin • GSK5733584 • adebrelimab (SHR-1316)
1m
New P1 trial • Combination therapy • Metastases
|
Erbitux (cetuximab) • cisplatin • carboplatin • Xtandi (enzalutamide capsule) • HS-20093 • adebrelimab (SHR-1316)
1m
New P2 trial • Combination therapy • Metastases
|
PD-L1 expression
|
gemcitabine • sorafenib • AiTan (rivoceranib) • oxaliplatin • adebrelimab (SHR-1316)
2ms
New P2 trial • Combination therapy
|
cisplatin • carboplatin • etoposide IV • famitinib (SHR 1020) • adebrelimab (SHR-1316)
2ms
Enrollment open
|
IL6 (Interleukin 6) • IL2RA (Interleukin 2 receptor, alpha) • CD40 (CD40 Molecule)
|
Lenvima (lenvatinib) • adebrelimab (SHR-1316)
2ms
New P2 trial • Metastases
|
cisplatin • gemcitabine • Lenvima (lenvatinib) • adebrelimab (SHR-1316)
2ms
New P2 trial
|
Avastin (bevacizumab) • capecitabine • oxaliplatin • adebrelimab (SHR-1316)
2ms
Phase I Study of SHR-2002 + SHR-1316 in Patients With Advanced Malignant Tumors (clinicaltrials.gov)
P1, N=50, Active, not recruiting, Atridia Pty Ltd. | Recruiting --> Active, not recruiting
Enrollment closed
|
adebrelimab (SHR-1316)
2ms
A Study of Adebrelimab in Combination With Apatinib Gemcitabine and Cisplatin in Biliary Tract Malignancies (clinicaltrials.gov)
P1, N=35, Recruiting, First Affiliated Hospital of Fujian Medical University | Not yet recruiting --> Recruiting
Enrollment open
|
cisplatin • gemcitabine • AiTan (rivoceranib) • adebrelimab (SHR-1316)
2ms
Single Arm, Prospective, Multicenter Clinical Study of TACE With Adebrelimab and Bevacizumab for Unresectable Hepatocellular Carcinoma (clinicaltrials.gov)
P2, N=71, Recruiting, The First Affiliated Hospital of Xiamen University | Not yet recruiting --> Recruiting
Enrollment open
|
Avastin (bevacizumab) • adebrelimab (SHR-1316)
2ms
New P2 trial
|
cisplatin • gemcitabine • AiTan (rivoceranib) • adebrelimab (SHR-1316)
2ms
New P2 trial • Metastases
|
docetaxel • adebrelimab (SHR-1316)
2ms
Adebrelimab, Camrelizumab Plus Apatinib as First-line Therapy in Patients With Advanced Hepatocellular Carcinoma (clinicaltrials.gov)
P1/2, N=52, Recruiting, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Not yet recruiting --> Recruiting
Enrollment open • Metastases
|
AiRuiKa (camrelizumab) • AiTan (rivoceranib) • adebrelimab (SHR-1316)
3ms
CAP 02: Study of Anti-PD-1/PD-L1 Antibody Plus Apatinib as Second-Line Treatment of Advanced Esophageal Squamous Cell (clinicaltrials.gov)
P2, N=125, Recruiting, The First Affiliated Hospital of Zhengzhou University | N=85 --> 125 | Trial completion date: Feb 2023 --> Dec 2024
Enrollment change • Trial completion date • Metastases
|
AiRuiKa (camrelizumab) • AiTan (rivoceranib) • adebrelimab (SHR-1316)
3ms
New P2 trial • Metastases
|
capecitabine • oxaliplatin • Fruzaqla (fruquintinib) • adebrelimab (SHR-1316)
3ms
New P2 trial • Metastases
|
AiRuiYi (fluzoparib) • adebrelimab (SHR-1316)
3ms
New P2 trial
|
IL6 (Interleukin 6) • IL2RA (Interleukin 2 receptor, alpha) • CD40 (CD40 Molecule)
|
Lenvima (lenvatinib) • adebrelimab (SHR-1316)
3ms
New P2 trial
|
adebrelimab (SHR-1316)
3ms
New P2 trial
|
carboplatin • etoposide IV • adebrelimab (SHR-1316)
3ms
New P2 trial • Metastases
|
cisplatin • paclitaxel • capecitabine • oxaliplatin • SHR-8068 • adebrelimab (SHR-1316)
3ms
New P2 trial
|
BRAF (B-raf proto-oncogene)
|
Erbitux (cetuximab) • 5-fluorouracil • oxaliplatin • irinotecan • adebrelimab (SHR-1316)
3ms
Efficacy and Safety of PD-L1 Monoclonal Antibody Combined With Metronomic VEX in Advanced Triple-negative Breast Cancer (clinicaltrials.gov)
P2, N=182, Not yet recruiting, Cancer Institute and Hospital, Chinese Academy of Medical Sciences
New P2 trial • Metastases
|
capecitabine • cyclophosphamide • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral) • adebrelimab (SHR-1316)
3ms
New P1 trial
|
AiRuiKang (dalpiciclib) • adebrelimab (SHR-1316)
3ms
New P1/2 trial • Metastases
|
trastuzumab rezetecan (SHR-A1811) • SHR-A2009 • adebrelimab (SHR-1316)
4ms
New P2 trial
|
cisplatin • gemcitabine • Lenvima (lenvatinib) • adebrelimab (SHR-1316)
4ms
New P2 trial
|
paclitaxel • 5-fluorouracil • lobaplatin (D19466) • adebrelimab (SHR-1316)
4ms
Breast Cancer Study of Stereotactic Body Radiation Therapy (SBRT) Combined Neoadjuvant Treatment (clinicaltrials.gov)
P=N/A, N=24, Active, not recruiting, Shengjing Hospital | Trial completion date: Oct 2023 --> Dec 2028 | Trial primary completion date: Jul 2023 --> Dec 2024
Trial completion date • Trial primary completion date
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
|
ER positive • HER-2 negative • ER positive + HER-2 negative
|
cisplatin • carboplatin • albumin-bound paclitaxel • AiRuiKang (dalpiciclib) • adebrelimab (SHR-1316)