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GENE:
NKX2-1 (NK2 Homeobox 1)
i
Other names:
NKX2-1, NK2 Homeobox 1, Thyroid Transcription Factor 1, TTF-1, TTF1, Thyroid-Specific Enhancer-Binding Protein, Homeobox Protein NK-2 Homolog A, Homeobox Protein Nkx-2.1, Thyroid Nuclear Factor 1, NKX2A, T/EBP, TITF1, NK-2 Homolog A, Benign Chorea, NKX2.1, NKX2-1, NMTC1, NK-2, TEBP, BCH, BHC
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Entrez ID:
7080
Related tests:
‹
AmoyDx® HANDLE Classic NGS Panel
AmoyDx® HANDLE Classic NGS Panel
›
Associations
(5)
News
Trials
VERI cancer hierarchy
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NKX2-1 amplification
Non Small Cell Lung Cancer
NKX2-1 amplification
Non Small Cell Lung Cancer
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
NKX2-1 expression + PD-L1 expression
Lung Non-Squamous Non-Small Cell Cancer
NKX2-1 expression + PD-L1 expression
Lung Non-Squamous Non-Small Cell Cancer
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
NKX2-1 expression
Merkel Cell Carcinoma
NKX2-1 expression
Merkel Cell Carcinoma
avelumab
Sensitive: C4 – Case Studies
avelumab
Sensitive
:
C4
avelumab
Sensitive: C4 – Case Studies
avelumab
Sensitive
:
C4
EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification
Non Small Cell Lung Cancer
EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification
Non Small Cell Lung Cancer
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
KRT7 positive + NKX2-1 positive + ALK overexpression
Lung Cancer
KRT7 positive + NKX2-1 positive + ALK overexpression
Lung Cancer
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
alectinib
Sensitive: C4 – Case Studies
alectinib
Sensitive
:
C4
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